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Social Phobia (Social Anxiety Disorder)

Featured Studies

Featured studies include only those currently recruiting participants. Studies with the most recent start date appear first.

  • Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response
    Study Type: Interventional
    Start Date: July 5, 2017
    Location: Chicago, Illinois
    Eligibility: Ages 18–65, Accepts Healthy Volunteers

    Many patients with Major Depressive Disorder (MDD) and generalized Social Anxiety Disorder (gSAD) are treated with cognitive behavioral therapy (CBT) but few have meaningful improvement. MDD and gSAD are diseases of brain dysfunction that manifest as impaired emotion regulation; CBT teaches emotion regulation strategies but how it works in the brain remains largely unknown. Individual differences in brain function related to emotion regulation may make some patients better suited for CBT and CBT may remedy the brain dysfunction that underlies these disorders. This project will compare CBT with a placebo psychotherapy (i.e., supportive therapy) in MDD and gSAD to test, validate, and refine brain-based markers and examine mechanisms of change to examine how CBT works and for whom.

  • Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety
    Study Type: Interventional
    Start Date: December 1, 2016
    Location: Ann Arbor, Michigan
    Eligibility: Ages 7–17, Accepts Healthy Volunteers

    Anxiety is among the most prevalent, costly and disabling illnesses and tends emerge early in childhood. Cognitive behavioral therapy (CBT) is the first-line treatment for early life anxiety, but as many as 40% of young patients who receive CBT fail to get better. The proposed study will examine brain changes marking positive response to CBT for anxiety and how these changes may differ in children compared adolescents. By helping us to understand how CBT works, this study will pave the way for new treatments to stop anxiety early.

  • Endogenous Opioid Mechanisms for Rejection Sensitivity
    Study Type: Observational
    Start Date: August 1, 2016
    Location: Ann Arbor, Michigan
    Eligibility: Ages 18–25, Accepts Healthy Volunteers

    This project hypothesizes that the brain's opioid system determines rejection sensitivity, a personality trait that is a vulnerability factor and feature of several psychiatric disorders. This project will use positron emission tomography to measure the brain's opioid response to social rejection and acceptance in a nonclinical population with varying levels of rejection sensitivity. The results will provide the first major step towards understanding a neurotransmitter mechanism for rejection sensitivity, allowing for further investigation into predicting and treating its associated disorders.

  • 1/2 A Multi-site Systems Intervention for Unemployed Persons With Social Anxiety
    Study Type: Interventional
    Start Date: January 1, 2016
    Location: Ann Arbor, Michigan
    Eligibility: Ages 18–60, Does Not Accept Healthy Volunteers

    Social anxiety disorder is a highly prevalent condition that interferes with employment. Prior research indicates that social anxiety disorder interferes with work attainment. This project involves a two-site randomized trial of a community-based cognitive-behavioral intervention to reduce social anxiety and improve employment outcomes among unemployed persons with social anxiety disorder.