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Rapid Antidepressant Effects of Ketamine

Join a Research Study: Enrolling nationally from around the country

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 1-866-411-1010].

If you (or someone you know) have been diagnosed with major depression, you may be able to participate in a trial designed to understand the causes of depression and rapid antidepressant response. Specifically, we are testing whether ketamine, a drug that affects glutamate in the brain will improve symptoms of depression within a matter of hours.

If you are 18-65 years of age and have been diagnosed with major depression (unipolar) and previously failed to respond to treatment, you may be eligible for an inpatient trial designed to bring about a rapid antidepressant effect.

After completion of the study the participant is transitioned back to a clinician in the community. In addition, all research participation is without cost and we will cover all transportation costs from anywhere in the United States. Compensation is provided for study procedures.