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Psychological Treatments for Youth with Severe Irritability

Join a Research Study: Enrolling locally from the Washington, D.C. metro region

To find out if you qualify, email NIMH or call 1-301-496-8381 [TTY: 1-866-411-1010].

This is a study to find out whether non-drug interventions can be effective for children who are very irritable. The two interventions are Cognitive Behavioral Therapy (CBT) (a kind of “talking therapy”) and Interpretation Bias Training (IBT) (a computer-based training). The purpose of this research is to learn whether these interventions will decrease irritability and temper outbursts in children with Disruptive Mood Dysregulation Disorder (DMDD). Compared to their peers, children with DMDD display chronic anger and irritability. They often have extreme responses, such as severe temper tantrums, when they become frustrated or when parents or teachers set limits on their behavior. Children ages 8 to 17 with DMDD who live within 50 miles of Bethesda Marylandmay be eligible to participate in this study. Children do not need to be on medication to participate in this study. Those who are currently receiving medications will remain on them throughout the study.

Participants may choose to participate in only CBT, only IBT, or IBT followed by CBT.

During CBT, children and their families participate in 12-16 outpatient sessions over up to 16 weeks. The study seeksto evaluate techniques and strategies to manage and reduce irritability and temper outbursts. The treatment includes practicing strategies at home between treatment sessions.

IBT is a 14-15 week computer-based learning program. It has three phases, each of which includes some outpatient visits and some computer use at home.

  • In Phase I, children participate in 18 days of initial training. Some of these training sessions are done in the clinic at the NIH and some are done at home. There are two different trainings—“active” and “not active.” The child’s assignment to “active” or “not-active” training in this phase is made randomly—like flipping a coin.
  • In Phase II children come to the NIH weekly eight times and complete training sessions. During this time, they continue to receive the same “active” or “not-active” training.
  • In Phase III, which lasts for 18 days, all children receive “active” training, and training sessions are done in the NIH clinic and at home, in the same manner as Phase I. Children and their families will be informed about which training group they were in when all the participants have completed the entire study.

All procedures associated with the research are provided at no cost to participants, and transportation expenses are reimbursed by NIMH.