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Principal Investigator: Yin Yao

Yin Yao

Unit on Statistical Genomics

Photo of Yin Yao


Dr. Yin Yao obtained her Ph.D. from Columbia University in New York City in 1996. After working one year as a postdoc fellow in the International Agency of Research on Cancer in Lyon, France, Dr. Yao returned to the States. She served as a Research Assistant Professor in University of Pittsburgh for one year and then took a Statistical Geneticist position at the Center for the Inherited Disease at Johns Hopkins University for two years. She then worked as a tenure-track faculty member in the Department of Epidemiology of Bloomberg School of Public Health at Johns Hopkins University between 2001 and 2007. She was promoted to Associate Professor in 2005. In 2007, Dr. Yao moved to the extramural program of NIMH to lead the program of Genetic Epidemiology while she maintained her research interest in method development. In the beginning of 2011, Dr. Yao took a position as the Chief of the Unit on Statistical Genomics at the Intramural Research Program (IRP) of NIMH.

Research Interests

Dr. Yao's current research interests include method development for analyzing next generation sequencing data and for data dimension reduction. She will also collaborate with both intramural and extramural scientists to apply the most effective statistical methods to analyze the emerging data sets with complex data structures, and mainly focus on mental health disorders and biomarker studies related to drug efficacy or side effects.

Selected Publications

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS . Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Murphy DL, Knowles JA, Grados MA, Riddle MA, Rasmussen SA, McLaughlin NC, Nurmi EL, Askland KD, Qin HD, Cullen BA, Piacentini J, Pauls DL, Bienvenu OJ, Stewart SE, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Lange C, Nestadt G. Mol Psychiatry. 2014; doi: 10.1038/mp.2014.43 PMID: 24821223.

Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study . Samuels J, Shugart YY, Wang Y, Grados MA, Bienvenu OJ, Pinto A, Rauch SL, Greenberg BD, Knowles JA, Fyer AJ, Piacentini J, Pauls DL, Cullen B, Rasmussen SA, Stewart SE, Geller DA, Maher BS, Goes FS, Murphy DL, McCracken JT, Riddle MA, Nestadt G. Am J Med Genet B Neuropsychiatr Genet. 2014;165:326-36. doi:10.1002/ajmg.b.32235 PMID: 24798771.

Sparse representation-based biomarker selection for schizophrenia with integrated analysis of fMRI and SNPs . Cao H, Duan J, Lin D, Shugart YY, Calhoun V, Wang YP. Neuroimage. 2014; S1053-8119(14)00042-1. doi: 10.1016/j.neuroimage. 2014.01.021 PMID: 24530838.

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture . Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen BA, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez TV, Gallagher PJ, Garrido H, Geller D, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Hadd. PLoS Genet. 2013: doi: 10.1371/journal.pgen.1003864 PMID: 24204291.

Weighted pedigree-based statistics for testing the association of rare variants . Shugart YY, Zhu Y, Guo W, Xiong M. BMC Genomics. 2012;13:667. doi: 10.1186/1471-2164-13-667 PMID: 23176082.

Exome sequencing and the genetic basis of complex traits . Kiezun A, Garimella K, Do R, Stitziel NO, Neale BM, McLaren PJ, Gupta N, Sklar P, Sullivan PF, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Lehner T, Shugart YY, Price AL, de Bakker PI, Purcell SM, Sunyaev SR. Nat Genet. 2012 ;44:623-30. doi: 10.1038/ng.2303 PMID: 22641211.

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