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Drevets WC, Zarate CA Jr, Furey ML. Antidepressant effects of the muscarinic cholinergic receptor antagonist scopolamine: a review. 2013 Jun 15;73(12):1156-63 [PMID: 23200525]

Duncan W, Selter J, Brutsche N, Sarasso S, Zarate Jr. Baseline delta sleep ratio predicts acute ketamine mood response in major depressive disorder. J Affect Disord 2013; 145(1):115-9. [PMID: 22871531]

Furey ML, Drevets WC, Frankel E, Hoffman EM, Speer AM, Zarate CA Jr. Pre-treatment neural activity in visual cortex during processing of emotion information predicts treatment response to scopolamine in major depressive disorder. JAMA Psychiatry. 2013 Mar;70(3):280-90. [PMID: 23364679]

Machado-Vieira R, Luckenbaugh D, Soeiro-de-Souza MG, Marca G, Busnello JV, Forlenza O, Gattaz WF, Zarate CA Jr. Early improvement with lithium in classic (euphoric) mania predicts later response. J Affect Disord 2013;144:160-4. [PMID: 22906798]

Moaddel R, Abdrakhmanova G, Kozak J, Jozwiak K, Toll L, Jimenez L, Rosenberg A, Thran T, Xiao Y, Zarate CA Jr, Wainer IW. Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in ?7 nicotinic acetylcholine receptors. Eur J Pharmacology 2013 Jan 5;698(1-3):228-34. [PMID: 23183107]

Nugent AC, Bain EE, Carlson PJ, Neumeister A, Bonne O, Carson RE, Eckelman W, Herscovitch P, Zarate CA Jr, Charney DS, Drevets WC. Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression. Eur Neuropsychopharmacol. 2013 Aug;23(8):822-9. [PMID: 23434290]

Nugent AC, Luckenbaugh DA, Wood SE, Bogers W, Zarate CA Jr, Drevets W. Automated subcortical segmentation using FIRST: Test-retest reliability, Inter-scanner reliability, and comparison to hand segmentation. Hum Brain Mapp. 2013 Sep;34(9):2313-29. [PMID: 22815187]

Soeiro-de-Souza MG, Salvadore G, Moreno RA, Otaduy MR, Chaim KT, Gattaz WF, Zarate CA Jr, Machado-Vieira R. Bcl-2 rs956572 Polymorphism is associated with increased anterior cingulate cortical glutamate in euthymic bipolar I disorder. Neuropsychopharmacology 2013 Feb;38(3):468-75. [PMID: 23072837]

Zarate CA Jr, Mathews D, Ibrahim L, Franco Chaves J, Marquardt C, Ukoh I, Jolkovsky L, Brutsche N, Smith MA, Luckenbaugh D. A randomized trial of a low trapping non-selective N-methyl-D-aspartate (NMDA) channel blocker in major depression. Biol Psychiatry 2013 Aug 15;74(4):257-64. [PMID: 23206319]


Aan Het Rot M, Zarate CA Jr, Charney DS, Mathew SJ. Ketamine for depression: where do we go from here? Biol Psychiatry 2012;72:548-554. [PMID: 22705040]

Cornwell BR, Salvadore G, Furey M, Marquardt CA, Brutsche NE, Grillon C, Zarate CA Jr. Synaptic potentiation is critical for rapid antidepressant response to ketamine. Biological Psychiatry 2012;72:555-561. [PMID: 22521148]

Duncan WC Jr, Selter J, Sarasso S, Luckenbaugh DA, Yuan P, Tononi G, Zarate CA Jr. Concomitant BDNF and slow wave sleep changes indicate ketamine-induced plasticity in major depressive disorder. Int J Neuropsychopharmacology 2012;7:1-11. [PMID: 22676966]

Fujita M, Hines CS, Zoghbi SS, Mallinger AG, Dickstein LP, Liow J-S, Hall M, Zhang Y, Pike VW, Drevets WC, Innis RB, Zarate CA Jr. Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram PET in major depressive disorder. Biol Psychiatry 2012;72:548-554. [PMID: 22677471]

Furey ML, Nugent AC, Speer AM, Luckenbaugh DA, Hoffman EM, Frankel E, Drevets WC, Zarate CA Jr. Baseline mood-state measures as predictors of antidepressant response to scopolamine. Psychiatry Res 2012;196:63-7. [PMID: 22349648]

Ibrahim L, Diazgranados N, Franco Chaves J, Cravchik A, Brutsche N, Newberg A, Kronstein P, Ameli R, Khalife S, Wainer I, Luckenbaugh DA, Manji HK, Zarate CA Jr. Course of improvement in depressive symptoms to a single-intravenous infusion of ketamine in a double-blind, placebo-controlled maintenance of response study with riluzole. Neuropsychopharmacology 2012;37:1526-33. [PMID: 22298121]

Ibrahim L, Diazgranados N, Jolkovsky L, Luckenbaugh DA, Herring WJ, Potter WZ, Zarate CA Jr. Brief reports: A randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder. J Clin Psychopharmacol 2012;32:551-7. [PMID: 22722512]

Kaddurah-Daouk R, Yuan P, Boyle S, Matson W, Wang Z, Zeng ZB, Zhu H, Dougherty, Yao J, Chen G, Guitart X, Carlson P, Neumeister A, Zarate CA Jr, Krishnan RR, Manji HK, Drevets W. Cerebrospinal fluid metabolome in mood disorders. Scientific Report 2012;2:667. [PMID: 22993692]

Khairova R, Zarate CA Jr, Machado-Vieira R. The selective effects of lithium on oxidative stress parameters in healthy volunteers. Molecular Medicine Reports 2012;5:680-682. [PMID: 22200861]

Kim P, Thomas LA, Rosen BH, Moscicki AM, Brotman MA, Zarate CA, Blair RJ, Pine DS, Leibenluft E. Differing amygdala responses to facial expressions in children and adults with bipolar disorder. Am J Psychiatry 2012;169:642-649. [PMID: 22535257]

Laje G, Lally N, Mathews D, Brutsche N, Chemerinski A, Akula N, Kelmendi B, Simen A, McMahon JF, Sanacora G, Zarate CA Jr. Brain-derived neurotrophic factor Vall66Met polymorphism and antidepressant efficacy of ketamine in depressed patients. Biol Psychiatry 2012;72:e27-8. [PMID: 22771240]

Luckenbaugh DA, Ibrahim L, Brutsche N, Franco-Chaves J, Mathews D, Marquardt CA, Cassarly C, Zarate CA Jr. Family history of alcohol dependence and antidepressant response to an N-methyl-D-aspartate antagonist in bipolar depression. Bipolar Disorders 2012;14:880-7. [PMID: 22978511]

Mathews D, Zarate CA Jr. Targeting the glutamatergic system to treat major depressive disorder: Rationale and progress to date. Drugs 2012;72:1313-1333. [PMID: 22731961]

Soeiro-de-Souza MG, Dias VV, Figueira ML, Forlenza OV, Gattaz WF, Zarate CA Jr, Machado-Vieira R. Translating neurotrophic and cellular plasticity: from pathophysiology to improved therapeutics for bipolar disorder. Acta Psychiatr Scand. 2012 Nov;126(5):332-41. [PMID: 22676371]

Turner A, Furey M, Drevets W, Zarate CA Jr, Nugent A. Association between subcortical volumes and verbal memory in unmedicated depressed patients and healthy controls. Neuropsychologia 2012;50:2348-55. [PMID: 22714007]

Zhao X, Venkata SL, Moaddel R, Luckenbaugh DA, Brutsche NE, Ibrahim L, Zarate CA Jr, Mager DE, Wainer IW. Simultaneous population pharmacokinetic modeling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression. Br J Pharmacol 2012;74:304-14. [PMID: 22295895]

Weathers JD, Stringaris A, Deveney CM, Brotman MA, Zarate CA Jr, Connolly ME, Fromm SJ, Pine DS, Leibenluft E. A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder. Am J Psychiatry 2012;169:633-41. [PMID: 22581312]

Zanotti-Fregonara P, Hines CS, Zoghbi SS, Liow J-S, Zhang Y, Pike VW, Drevets WC, Mallinger A, Zarate CA Jr, Fujita M, Innis RB. Population-based input function and image-derived input function are accurate and precise alternatives to serial arterial blood sampling for [11C](R)-rolipram PET imaging. Neuroimage 2012;63:1532-1541. [PMID: 22906792]

Zarate CA Jr, Brutsche NE, Ibrahim L, Franco-Chaves J, Diazgranados N, Cravchik A, Selter J, Marquardt CA, Liberty V, Luckenbaugh. Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled trial. Biol Psychiatry 2012;71:939-46. [PMID: 22297150]

Zarate CA Jr, Franco Chaves J, Brutsche N, Ibrahim L, Laje G, Luckenbaugh DA, Ramamoorthy A, Moaddel R, Wainer I. Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial. Biol Psychiatry 2012:72:331-8. [PMID: 22297150]


Hunsberger J, Machado-Vieira R, Austin D, Zarate CA, Chuang D-M, Chen G, Reed J, Husseini MK. Bax inhibitor-1, a modulator of endoplasmic reticulum cellular stress, confers affective resilience. Brain Res. 2011 Jul 27;1403:19-27. [PMID: 22200861]

Ibrahim L, Diazgranados N, Luckenbaugh DA, Machado-Vieira R, Bauman J, Mallinger AG, Zarate CA Jr. Rapid antidepressant response to an N-methyl-D-aspartate antagonist in ECT-resistant major depression. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1155-9. [PMID: 21466832]

Ibrahim L, Duncan W, Luckenbaugh DA, Yuan P, Machado-Vieira R, Zarate CA Jr. Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): a pilot study. Brain Res Bull 2011;86:129-33. [PMID: 21704134]

Javitt DC, Schoepp D, Kalivas P, Volkow N, Zarate C, Bear M, Umbricht D, Hajos M, Potter W, Lee C-M. Translating glutamate: from pathophysiology to treatment. Science Translational Medicine 2011 Sep 28;3(102):102mr2. [PMID: 21957170]

Machado-Vieira R, Ibrahim L, Henter I, Zarate CA Jr. Novel glutamatergic agents for major depressive disorder and bipolar disorder. Pharmacology, Biochemistry and Behavior 2011;100:678-687. [PMID: 21971560]

Machado-VieiraR, Pivovarova NB, Stanika RI, Zarate CA Jr, Drevets WC, Brantner CA, Baum A, Laje G, McMahon FJ, Chen G, Du J, Manji HK, Andrews B: A Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-triphosphate receptor -mediated endoplasmic reticulum calcium release in subjects with bipolar disorder. Biol Psychiatry. 2011 Feb 15;69(4):344-52. [PMID: 21167476]

Malkesman O, G, Austin DR, Tragon T, Rompala G, Hamidi AB, Cui Z, Young S, Luckenbaugh DMA4, Zarate CA, Manji HK, Nakazawa K, Guang Chen G: Acute D-serine treatment produces antidepressant-like effects in rodents. Int J Neuropsychopharmacol 2011;12:1-14. [PMID: 21906419]

Salvadore G, van der Veen JW, Zhang Y, Machado-Vieira R, Baumann J, Luckenbaugh DA, Shen J, Drevets WC. Zarate CA Jr. An investigation of amino acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression. Int J Neuropsychopharmacology 2011:1:1-10. [PMID: 22040773]

Savitz JB, Nugent AC, Bogers W, Roiser JP, Bain EE, Neumeister A, Zarate CA Jr, Manji HK, Cannon DM, Marrett S, Henn F, Charney DS, Drevets WC. Habenula volume in bipolar disorder and major depressive disorder: A high resolution MRI study. Biol Psychiatry 2011;69:336-43. [PMID: 21094939]


Cornwell BR, Salvadore G, Colon-Rosario V, Latov D, Holroyd T, Carver FW, Coppola R, Manji HK, Zarate CA Jr., Grillon C. Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals. Am J Psychiatry 2010;167:836-844. [PMID: 20439387]

DiazGranados, Ibrahim L, Brutsche N, Ameli R, Henter I, Luckenbaugh D, Machado-Vieira R, Zarate CA Jr. Rapid resolution of suicidal ideation after a single ketamine infusion in patients with treatment-resistant major depression. J Clin Psychiatry, 2010;71:1605-11. [PMID: 20673547]

Diazgranados N, Ibrahim L, Brutsche NE, Newberg A, Kronstein P, Khalife S, Kammerer WA, Quezado Z, Luckenbaugh DA, Salvadore G, Machado-Vieira R, Manji HK, Zarate CA Jr. A randomized add-on trial of an N-methyl-D-aspartate (NMDA) antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry 2010;67:793-802. [PMID: 20679587]

Salvadore G, Cornwell BR, Sambataro F, Latov D, Colon-Rosario V, Carver F, Holroyd T, Machado-Vieira R, Grillon C, Drevets WC, Zarate CA Jr. Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine. Neuropsychopharmacology 2010;35:1415-1422. [PMID: 20393460]

Savitz J, Nugent A, Bogers w, Liu A, Sills R, Luckenbaugh D, Bain E, Price, Zarate CA Jr, Manji HK, Cannon, Marrett S, Charney D, Drevets W. Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication. Neuroimage, 2010;49:2966-76. [PMID: 19931399]


Salvadore G, Nugent AC, Chen G, Akula N, Yuan P, Cannon DM, Zarate CA Jr, McMahon FJ, Manji HK, Drevets WC. Bcl-2 polymorphism influences gray matter volume in the ventral striatum of healthy volunteers. Biol Psychiatry 2009;15:66:804-7. [PMID: 19589501]


Maeng S, Zarate CA Jr, Du J, Schloesser R, McCammon J, Chen G, Manji HK. Cellular mechanism underlying the antidepressant effects of ketamine: role of AMPA receptors. Biol Psychiatry 2008;63:349-352 [PMID: 17643398]

Sanacora G, Zarate CA Jr*, Krystal J, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews Drug Discovery 2008;7:426-437. [PMID: 22731961]


Du J, Wei J, Chen Z, Falke C, Zarate CA Jr, Manji HK. The anticonvulsants lamotrigine, riluzole and valproate differentially regulate AMPA receptor trafficking: relationship to clinical effects in mood disorders. Neuropsychopharmacology 2007;32:793-802. [PMID: 16936714]

Gould NF, Holmes, KM, Luckenbaugh DA, Fantie BD, Pine DS, Burgess N, Manji HK, Zarate CA Jr. Performance on a virtual reality spatial memory navigation task in depressed patients. Am J Psychiatry 2007;164:516-519. [PMID: 17329478]

Mah L, Zarate CA, Carson R, Singh J, Duan Y-F, Luckenbaugh, Manji HK, Drevets WC. Regional glucose metabolic abnormalities in bipolar II depression. Biol Psychiatry 2007;61:765-775. [PMID: 17027930]

Zarate CA Jr, Singh JB, Carlson PJ, Quiroz J, Jolkovsky L, Luckenbaugh DA, Manji HK. Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study. Bipolar Disorders 2007;9:551-560. [PMID: 17845270]


Nugent AC, Milham MP, Bain EE, Mah L, Cannon DM, Marrett S, Zarate CA, Pine DS, Price JL, Drevets WC. Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry. Neuroimage 2006;30:485-97. [PMID: 16256376]

Zarate CA, Jr, Singh J, Carlson P, Brutsche N, Ameli R, Luckenbaugh D, Charney DS, Manji HK. A Randomized Trial of an NMDA Antagonist in Treatment-Resistant Major Depression. Arch Gen Psychiatry, 2006;63:856-64. [PMID:16894061]

Zarate CA Jr, Singh J, Manji HK. Cellular plasticity cascades: targets for the development of novel therapeutics for Bipolar Disorder. Biological Psychiatry, 2006 1;59:1006-1020. [PMID:16487491]

Zarate CA Jr, Singh J, Quiroz, JA, Denicoff KD, De Jesus G, Luckenbaugh D, Manji HK, Charney DS. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry, 2006;163:153-15 [PMID: 16390905]


Zarate CA Jr, Singh J, Quiroz J, De Jesus G, Denicoff K, Luckenbaugh D, Manji HK, Charney DS. An Open-label trial of the glutamate modulating agent riluzole in combination with lithium for the treatment of bipolar depression. Biol Psychiatry 2005;57:430-432 [PMID:15705360]