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Dr. Carlos Zarate

Dr. Carlos A. Zarate, Jr., MD
Chief, Experimental Therapeutics and Pathophysiology Branch

Dr. Carlos A. Zarate, Jr., MD, Chief of the Experimental Therapeutics and Pathophysiology Branch, earned his medical degree from the Catholic University of Cordoba in Argentina. He completed a clinical psychopharmacology fellowship at McLean Hospital in 1993, after which he remained on staff until 1998. In 1998, Dr. Zarate joined the faculty at the University of Massachusetts Medical School. In 2001, Dr. Zarate joined the Mood and Anxiety Disorders program at the NIMH and, in 2009, formed the Experimental Therapeutics and Pathophysiology Branch (ETPB). A multidisciplinary translational research team conducts the research in the ETPB. The Branch also provides training to develop the next generation of clinical translational researchers.

Research Interests

Dr. Zarate's current research focus is on developing novel medications for treatment-resistant depression and bipolar disorder. His areas of expertise include biological and pharmacological aspects of mood disorders in adults. The ETPB conducts proof-of-concept studies utilizing novel compounds and biomarkers (magnetoencephalography and polysomnography, positron emission tomography, functional MRI and magnetic resonance spectroscopy) to identify potentially relevant drug targets and biosignatures of treatment response. Dr. Zarate has published more than 200 papers on these topics.

Awards & Honors

Dr. Zarate’s achievements and awards include the Ethel-DuPont Warren Award and Livingston Awards, Consolidated Department of Psychiatry, Harvard Medical School; Outstanding Psychiatrist Research Award, Massachusetts Psychiatric Association; Program for Minority Research Training in Psychiatry, American Psychiatric Association; NIH-NIMH Travel Award, 1994; American College of Neuropsychopharmacology Travel Awards 1994 and 1995; the National Alliance for Research on Schizophrenia and Depression Young Investigator Award, 1996-1998; The Diversity and Advocacy Award, Hispanic Research Initiative Committee, NIMH, 2002; the Mentor of the Year, Intramural Research Program NIMH, 2004; the Supervisor of the Year NIMH, 2005; the National Alliance for Research on Schizophrenia and Depression Independent Investigator Award, 2005; the NIH Director’s Award-Scientific/Medical, 2009, and the Brain & Behavior Research Foundation Award for Bipolar Mood Disorder Research (NARSAD), 2011; The National Institute of Health Director’s Award—Scientific/Medical Achievement, 2013; and, the Mogens Schou Research Award: Bipolar Disorder, 2013.

Principal Investigators

Carlos A. Zarate, M.D.
Clinical Trials, Neuropsychopharmacology, Psychiatry

Rodrigo Machado-Vieira, M.D., Ph.D.
Biomarkers, Clinical Trials, Psychiatry

Allison Nugent, Ph.D.
Physics, Imaging, Development of functional and structural MRI techniques

Lawrence Park, M.D.
Clinical Trials, Neuromodulation, Psychiatry


Nancy Brutsche, M.S.N.
Clinical Nurse Specialist

Madeline Gupta, R.N., M.A.
Psychiatric Nursing

Immaculata Ukoh, M.S.N., C.R.N.P.


Rezvan Ameli, Ph.D.
Clinical Psychology

Yamila Carmona, MA
Clinical Psychology Research

Wallace Duncan, Ph.D.
Neuroscience, Sleep, Circadian Biology

Brenda Gray, Th.M.
Clinical Care Coordinator

Libby Jolkovsky, M.S.
Psychology, Community Relations & Recruitment

Eva Kakoza, B.S.
Operations Coordinator

David Luckenbaugh, M.A.

Alex Noury, M.A.
Protocol Coordinator, Regulatory

Joanna Szczepanik, M.A.
Clinical Psychology, Cognitive Science, Neuroscience


Tyler Ard, Ph.D.

Elizabeth Ballard, Ph.D.
Clinical Psychology

Jessica Ihne, Ph.D.

Níall Lally, M.Sc.
Psychology, Imaging

Valeria Martinez, M.S.
Clinical Health Psychology & Behavioral Medicine

Mark Niciu, M.D., Ph.D.
Psychiatry, Neuroscience

Minkyung Park, M.D.

Erica Richards, M.D., Ph.D.
Psychiatry, Neuroscience

Intramural Research Training Awardees (IRTAs)

Dipavo Banerjee

Hannah Berg

Nicolas Iadarola

Brittany Jaso

Nancy Lundin

Rory Pettigrew

Elizabeth Slonena

Tessa Walls