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Genetic Epidemiology Research Branch

Recent Publications

Mood disorders and circulating levels of inflammatory markers in a longitudinal population-based study. Glaus J, von Känel R, Lasserre AM, Strippoli MF, Vandeleur CL, Castelao E, Gholam-Rezaee M, Marangoni C, Wagner EN, Marques-Vidal P, Waeber G, Vollenweider P, Preisig M, Merikangas KR. Psychol Med. 2017 Sep 20:1-13. PMID: 28929992

Dysregulation of objectively assessed 24-hour motor activity patterns as a potential marker for bipolar I disorder: results of a community-based family study. Paksarian D, Trabjerg BB, Merikangas KR, Mors O, Børglum AD, Hougaard DM, McGrath JJ, Pedersen CB, Mortensen PB, Agerbo E. Psychol Med. 2017 Jun 29:1-10. PMID: 28659227

The role of genetic liability in the association of urbanicity at birth and during upbringing with schizophrenia in Denmark. Paksarian D, Trabjerg BB, Merikangas KR, Mors O, Børglum AD, Hougaard DM, McGrath JJ, Pedersen CB, Mortensen PB, Agerbo E. Psychol Med. 2017 Jun 29:1-10. PMID: 28659227

A genetic risk score is differentially associated with migraine with and without aura. Pisanu C, Preisig M, Castelao E, Glaus J, Pistis G, Squassina A, Del Zompo M, Merikangas KR, Waeber G, Vollenweider P, Mwinyi J, Schiöth HB. Hum Genet. 2017 Aug;136(8):999-1008. PMID: 28656458

Neurocognitive performance as an endophenotype for mood disorder subgroups. Merikangas AK, Cui L, Calkins ME, Moore TM, Gur RC, Gur RE, Merikangas KR. J Affect Disord. 2017 Jun;215:163-171. PMID: 28340442

Future Surveillance of Mental Disorders in the United States: Count People, Not Disorders. Merikangas KR, Bromet EJ, Druss BG. JAMA Psychiatry. 2017 May 1;74(5):431-432. PMID: 28329225

Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two-year follow-up. Calkins ME, Moore TM, Satterthwaite TD, Wolf DH, Turetsky BI, Roalf DR, Merikangas KR, Ruparel K, Kohler CG, Gur RC, Gur RE. World Psychiatry. 2017 Feb;16(1):62-76. PMID: 28127907

Stability and change in reported age of onset of depression, back pain, and smoking over 29 years in a prospective cohort study. Paksarian D, Cui L, Angst J, Ajdacic-Gross V, Rössler W, Merikangas KR. J Psychiatr Res. 2017 May;88:105-112. PMID: 28113111

Activation in Bipolar Disorders: A Systematic Review. Scott J, Murray G, Henry C, Morken G, Scott E, Angst J, Merikangas KR, Hickie IB. JAMA Psychiatry. 2017 Feb 1;74(2):189-196. PMID: 28002572

Sleep Patterns and Mental Health Correlates in US Adolescents. Zhang J, Paksarian D, Lamers F, Hickie IB, He J, Merikangas KR. J Pediatr. 2017 Mar;182:137-143. PMID: 27939122

Correlates of Overweight and Obesity Among Adolescents With Bipolar Disorder in the National Comorbidity Survey-Adolescent Supplement (NCS-A). Goldstein BI, Blanco C, He JP, Merikangas K. J Am Acad Child Adolesc Psychiatry. 2016 Dec;55(12):1020-1026. PMID: 27871636

Latent Trajectories of Common Mental Health Disorder Risk Across 3 Decades of Adulthood in a Population-Based Cohort. Paksarian D, Cui L, Angst J, Ajdacic-Gross V, Rössler W, Merikangas KR. JAMA Psychiatry. 2016 Oct 1;73(10):1023-1031. PMID: 27602550

Familial aggregation and heritability of the melancholic and atypical subtypes of depression. Lamers F, Cui L, Hickie IB, Roca C, Machado-Vieira R, Zarate CA Jr, Merikangas KR. J Affect Disord. 2016 Nov 1;204:241-6. PMID: 27450632

Medical Comorbidity of Attention-Deficit/Hyperactivity Disorder in US Adolescents.
Jameson ND, Sheppard BK, Lateef TM, Vande Voort JL, He JP, Merikangas KR.
J Child Neurol. 2016 Oct;31(11):1282-9. PMID: 27334310

Reexamining associations between mania, depression, anxiety and substance use disorders: results from a prospective national cohort. Olfson M, Mojtabai R, Merikangas KR, Compton WM, Wang S, Grant BF, Blanco C. Mol Psychiatry. 2017 Feb;22(2):235-241. PMID: 27137742

High leptin levels are associated with migraine with aura. Pisanu C, Preisig M, Castelao E, Glaus J, Cunningham JL, Del Zompo M, Merikangas KR, Schiöth HB, Mwinyi J. Cephalalgia. 2017 Apr;37(5):435-441. PMID: 27165492

Association of Lifetime Mental Disorders and Subsequent Alcohol and Illicit Drug Use: Results From the National Comorbidity Survey-Adolescent Supplement. Conway KP, Swendsen J, Husky MM, He JP, Merikangas KR. J Am Acad Child Adolesc Psychiatry. 2016 Apr;55(4):280-8. PMID: 27015718

Disruptive Mood Dysregulation Disorder at Ages 13-18: Results from the National Comorbidity Survey-Adolescent Supplement. Althoff RR, Crehan ET, He JP, Burstein M, Hudziak JJ, Merikangas KR. J Child Adolesc Psychopharmacol. 2016 Mar;26(2):107-13. PMID: 26771536

Racial-ethnic disparities in empirically-derived subtypes of subclinical psychosis among a U.S. sample of youths. Paksarian D, Merikangas KR, Calkins ME, Gur RE. Schizophr Res. 2016 Jan;170(1):205-10. PMID: 26711527

The specificity of the familial aggregation of early-onset bipolar disorder: A controlled 10-year follow-up study of offspring of parents with mood disorders. Preisig M, Strippoli MF, Castelao E, Merikangas KR, Gholam-Rezaee M, Marquet P, Aubry JM, Vandeleur CL. J Affect Disord. 2016 Jan 15;190:26-33. PMID: 26480208

The Impact of Post-Traumatic Stress Disorder on the Burden of Migraine: Results From the National Comorbidity Survey-Replication. Rao AS, Scher AI, Vieira RV, Merikangas KR, Metti AL, Peterlin BL. Headache. 2015 Nov-Dec;55(10):1323-41. PMID: 26473981

Prevalence of migraine in a diverse community--electronic methods for migraine ascertainment in a large integrated health plan. Pressman A, Jacobson A, Eguilos R, Gelfand A, Huynh C, Hamilton L, Avins A, Bakshi N, Merikangas K. Cephalalgia. 2016 Apr;36(4):325-34. PMID: 26069243

School Start Time and Adolescent Sleep Patterns: Results From the U.S. National Comorbidity Survey--Adolescent Supplement. Paksarian D, Rudolph KE, He JP, Merikangas KR. Am J Public Health. 2015 Jul;105(7):1351-7. PMID: 25973803

A population-based study of the risk of schizophrenia and bipolar disorder associated with parent-child separation during development. Paksarian D, Eaton WW, Mortensen PB, Merikangas KR, Pedersen CB. Psychol Med. 2015 Oct;45(13):2825-37. PMID: 25952483

The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative. Calkins ME, Merikangas KR, Moore TM, Burstein M, Behr MA, Satterthwaite TD, Ruparel K, Wolf DH, Roalf DR, Mentch FD, Qiu H, Chiavacci R, Connolly JJ, Sleiman PMA, Gur RC, Hakonarson H, Gur RE. J Child Psychol Psychiatry. 2015 Dec;56(12):1356-1369. PMID: 25858255

The epidemiology of common mental disorders from age 20 to 50: results from the prospective Zurich cohort Study. Angst J, Paksarian D, Cui L, Merikangas KR, Hengartner MP, Ajdacic-Gross V, Rössler W. Epidemiol Psychiatr Sci. 2016 Feb;25(1):24-32. PMID: 25802979

Comorbidity of physical and mental disorders in the neurodevelopmental genomics cohort study. Merikangas KR, Calkins ME, Burstein M, He JP, Chiavacci R, Lateef T, Ruparel K, Gur RC, Lehner T, Hakonarson H, Gur RE. Pediatrics. 2015 Apr;135(4):e927-38. PMID: 25755242

Accuracy of family history reports of migraine in a community-based family study of migraine. Lateef TM, Cui L, Nakamura E, Dozier J, Merikangas K. Headache. 2015 Mar;55(3):407-12. PMID: 25676478

The space of common psychiatric disorders in adolescents: comorbidity structure and individual latent liabilities. Blanco C, Wall MM, He JP, Krueger RF, Olfson M, Jin CJ, Burstein M, Merikangas KR. J Am Acad Child Adolesc Psychiatry. 2015 Jan;54(1):45-52. PMID: 25524789

Major depression in the national comorbidity survey-adolescent supplement: prevalence, correlates, and treatment. Avenevoli S, Swendsen J, He JP, Burstein M, Merikangas KR. J Am Acad Child Adolesc Psychiatry. 2015 Jan;54(1):37-44.e2. PMID: 25524788

Contrasting and convergent patterns of amygdala connectivity in mania and depression: a resting-state study. Li M, Huang C, Deng W, Ma X, Han Y, Wang Q, Li Z, Guo W, Li Y, Jiang L, Lei W, Hu X, Gong Q, Merikangas KR, Palaniyappan L, Li T. J Affect Disord. 2015 Mar 1;173:53-8. PMID: 25462396

Health correlates of insomnia symptoms and comorbid mental disorders in a nationally representative sample of US adolescents. Blank M, Zhang J, Lamers F, Taylor AD, Hickie IB, Merikangas KR. Sleep. 2015;38(2):197-204. PMID: 25325502

The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. Calkins ME, Moore TM, Merikangas KR, Burstein M, Satterthwaite TD, Bilker WB, Ruparel K, Chiavacci R, Wolf DH, Mentch F, Qiu H, Connolly JJ, Sleiman PA, Hakonarson H, Gur RC, Gur RE. World Psychiatry. 2014 Oct;13(3):296-305. PMID: 25273303

Associations between mood, anxiety or substance use disorders and inflammatory markers after adjustment for multiple covariates in a population-based study. Glaus J, Vandeleur CL, von Känel R, Lasserre AM, Strippoli MP, Gholam-Rezaee M, Castelao E, Marques-Vidal P, Bovet P, Merikangas K, Mooser V, Waeber G, Vollenweider P, Aubry JM, Preisig M. J Psychiatr Res. 2014 Nov;58:36-45. PMID: 25088287

Suicidal behavior in adolescents and adults with bulimia nervosa. Crow SJ, Swanson SA, le Grange D, Feig EH, Merikangas KR. Compr Psychiatry. 2014 Oct;55(7):1534-9. PMID: 25070478

The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort. Robinson EB, Kirby A, Ruparel K, Yang J, McGrath L, Anttila V, Neale BM, Merikangas K, Lehner T, Sleiman PM, Daly MJ, Gur R, Gur R, Hakonarson H. Mol Psychiatry. 2015 Apr;20(4):454-8. PMID: 25023143

Treatment patterns of youth with bipolar disorder: results from the National Comorbidity Survey-Adolescent Supplement (NCS-A). Khazanov GK, Cui L, Merikangas KR, Angst J. J Abnorm Child Psychol. 2015 Feb;43(2):391-400. PMID: 24958307

Impact of the DSM-5 attention-deficit/hyperactivity disorder age-of-onset criterion in the US adolescent population. Vande Voort JL, He JP, Jameson ND, Merikangas KR. J Am Acad Child Adolesc Psychiatry. 2014 Jul;53(7):736-44. PMID: 24954823

The structured diagnostic interview for sleep patterns and disorders: rationale and initial evaluation. Merikangas KR, Zhang J, Emsellem H, Swanson SA, Vgontzas A, Belouad F, Blank MM, Chen W, Einen M, He JP, Heaton L, Nakamura E, Rooholamini S, Mignot E. Sleep Med. 2014 May;15(5):530-5. PMID: 24780136

Threshold and subthreshold generalized anxiety disorder among US adolescents: prevalence, sociodemographic, and clinical characteristics. Burstein M, Beesdo-Baum K, He JP, Merikangas KR. Psychol Med. 2014 Jan 2:1-12. PMID: 24384401

The association between cortisol and neighborhood disadvantage in a U.S. population-based sample of adolescents.Rudolph KE, Gary S W, Stuart EA, Glass TA, Marques AH, Duncko R, Merikangas KR.Health Place. 2014 Jan;25:68-77. PMID: 24367996

Services for adolescents with psychiatric disorders: 12-month data from the National Comorbidity Survey-Adolescent.Costello EJ, He JP, Sampson NA, Kessler RC, Merikangas KR.Psychiatr Serv. 2014 Mar 1;65(3):359-66. PMID: 24233052

Independence of familial transmission of mania and depression: results of the NIMH family study of affective spectrum disorders. Merikangas KR, Cui L, Heaton L, Nakamura E, Roca C, Ding J, Qin H, Guo W, Shugart YY, Zarate C, Angst J. Mol Psychiatry. 2014 Feb;19(2):214-9. PMID: 24126930

Specificity of psychosis, mania and major depression in a contemporary family study. Vandeleur CL, Merikangas KR, Strippoli MP, Castelao E, Preisig M. Mol Psychiatry. 2014 Feb;19(2):209-13. PMID: 24126925

Adolescents and young adults who are not in employment, education, or training. Scott J, Fowler D, McGorry P, Birchwood M, Killackey E, Christensen H, Glozier N, Yung A, Power P, Nordentoft M, Singh S, Brietzke E, Davidson S, Conus P, Bellivier F, Delorme R, Macmillan I, Buchanan J, Colom F, Vieta E, Bauer M, McGuire P, Merikangas K, Hickie I.BMJ. 2013 Sep 18. PMID: 24048295

Episodic migraine and obesity and the influence of age, race, and sex. Peterlin BL, Rosso AL, Williams MA, Rosenberg JR, Haythornthwaite JA, Merikangas KR, Gottesman RF, Bond DS, He JP, Zonderman AB. Neurology. 2013 Oct 8;81(15):1314-21. PMID: 24027060

Neighborhood disadvantage in context: the influence of urbanicity on the association between neighborhood disadvantage and adolescent emotional disorders. Rudolph KE, Stuart EA, Glass TA, Merikangas KR. Soc Psychiatry Psychiatr Epidemiol. 2014 Mar;49(3):467-75PMID: 23754682

Differentiating nonrestorative sleep from nocturnal insomnia symptoms: demographic, clinical, inflammatory, and functional correlates.Zhang J, Lamers F, Hickie IB, He JP, Feig E, Merikangas KR.Sleep. 2013 May 1;36(5):671-9. PMID: 23633749

Prevalence and correlates of prolonged fatigue in a U.S. sample of adolescents. Lamers F, Hickie I, Merikangas KR.Am J Psychiatry. 2013 May 1;170(5):502-10. PMID: 23632835

Psychotropic medication treatment of adolescents: results from the National Comorbidity Survey-Adolescent Supplement.Olfson M, He JP, Merikangas KR.J Am Acad Child Adolesc Psychiatry. 2013 Apr;52(4):378-88. PMID: 23582869

Contributions of epidemiology to our understanding of migraine. Merikangas KR.Headache. 2013 Feb;53(2):230-46. PMID: 23432441

Medication use in US youth with mental disorders.Merikangas KR, He JP, Rapoport J, Vitiello B, Olfson M.JAMA Pediatr. 2013 Feb;167(2):141-8.PMID: 23403911

Validation of a migraine interview for children and adolescents. Lateef T, Cui L, Heaton L, Nakamura EF, Ding J, Ahmed S, Merikangas KR. Pediatrics. 2013 Jan;131(1):e96-102. PMID: 23266928

Atypical depression and alcohol misuse are related to the cardiovascular risk in the general population.Glaus J, Vandeleur C, Gholam-Rezaee M, Castelao E, Perrin M, Rothen S, Bovet P, Marques-Vidal P, von Känel R, Merikangas K, Mooser V, Waterworth DM, Waeber G, Vollenweider P, Preisig M. Acta Psychiatr Scand. 2012 Dec 7. PMID: 23216242

The Strengths and Difficulties Questionnaire (SDQ): the factor structure and scale validation in U.S. adolescents.He JP, Burstein M, Schmitz A, Merikangas KR. J Abnorm Child Psychol. 2013 May;41(4):583-95. PMID: 23183936

Specific phobia among U.S. adolescents: phenomenology and typology. Burstein M, Georgiades K, He JP, Schmitz A, Feig E, Khazanov GK, Merikangas K. Depress Anxiety. 2012 Dec;29(12):1072-82. PMID: 23108894

Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Lamers F, Vogelzangs N, Merikangas KR, de Jonge P, Beekman AT, Penninx BW. Mol Psychiatry. 2013 Jun;18(6):692-9.PMID: 23089630

Mental disorders in offspring of parents with bipolar and major depressive disorders. Vandeleur C, Rothen S, Gholam-Rezaee M, Castelao E, Vidal S, Favre S, Ferrero F, Halfon O, Fumeaux P, Merikangas KR, Aubry JM, Burstein M, Preisig M. Bipolar Disord. 2012 Sep;14(6):641-53.PMID: 22938168

Twelve-month suicidal symptoms and use of services among adolescents: results from the National Comorbidity Survey.Husky MM, Olfson M, He JP, Nock MK, Swanson SA, Merikangas KR. Psychiatr Serv. 2012 Oct;63(10):989-96.PMID: 22910768

Structure of major depressive disorder in adolescents and adults in the US general population.Lamers F, Burstein M, He JP, Avenevoli S, Angst J, Merikangas KR. Br J Psychiatry. 2012 Aug;201:143-50. PMID: 22700082

Mania with and without depression in a community sample of US adolescents. Merikangas KR, Cui L, Kattan G, Carlson GA, Youngstrom EA, Angst J. Arch Gen Psychiatry. 2012 Sep;69(9):943-51.PMID: 22566563

Epidemiology of substance use disorders. Merikangas KR, McClair VL.Hum Genet. 2012 Jun;131(6):779-89.PMID: 22543841

Use and abuse of alcohol and illicit drugs in US adolescents: results of the National Comorbidity Survey-Adolescent Supplement.Swendsen J, Burstein M, Case B, Conway KP, Dierker L, He J, Merikangas KR.Arch Gen Psychiatry. 2012 Apr;69(4):390-8. PMID: 22474107

Severity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement.Kessler RC, Avenevoli S, Costello J, Green JG, Gruber MJ, McLaughlin KA, Petukhova M, Sampson NA, Zaslavsky AM, Merikangas KR.Arch Gen Psychiatry. 2012 Apr;69(4):381-9. PMID: 22474106

Eating disorder not otherwise specified presentation in the US population. Le Grange D, Swanson SA, Crow SJ, Merikangas KR .Int J Eat Disord. 2012 Jul;45(5):711-8. PMID: 22407912

Cigarette smoking and mood disorders in U.S. adolescents: sex-specific associations with symptoms, diagnoses, impairment and health services use.Richardson A, He JP, Curry L, Merikangas K.J Psychosom Res. 2012 Apr;72(4):269-75. PMID: 22405220

Physical comorbidity of migraine and other headaches in US adolescents. Lateef TM, Cui L, Nelson KB, Nakamura EF, Merikangas KR. J Pediatr. 2012 Aug;161(2):308-13.e1. PMID: 22381023

Update on the genetics of migraine. Merikangas KR. Headache. 2012 Mar;52(3):521-2. PMID: 22375730

Stability and transitions of depressive subtypes over a 2-year follow-up. Lamers F, Rhebergen D, Merikangas KR, de Jonge P, Beekman AT, Penninx BW. Psychol Med. 2012 Oct;42(10):2083-93. PMID: 22340131

Lifetime co-morbidity of DSM-IV disorders in the US National Comorbidity Survey Replication Adolescent Supplement (NCS-A).Kessler RC, Avenevoli S, McLaughlin KA, Green JG, Lakoma MD, Petukhova M, Pine DS, Sampson NA, Zaslavsky AM, Merikangas KR.Psychol Med. 2012 Sep;42(9):1997-2010. PMID: 22273480

Transitions to regular smoking and nicotine dependence in the Adolescent National Comorbidity Survey (NCS-A). Dierker L, Swendsen J, Rose J, He J, Merikangas K; Tobacco Etiology Research Network (TERN).Ann Behav Med. 2012 Jun;43(3):394-401. PMID: 22160800

The 'true' prevalence of bipolar II disorder.Merikangas KR, Lamers F.Curr Opin Psychiatry. 2012 Jan;25(1):19-23. doi: 10.1097/YCO.0b013e32834de3de. Review.PMID: 22156934

Prevalence, persistence, and sociodemographic correlates of DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement. Kessler RC, Avenevoli S, Costello EJ, Georgiades K, Green JG, Gruber MJ, He JP, Koretz D, McLaughlin KA, Petukhova M, Sampson NA, Zaslavsky AM, Merikangas KR. Arch Gen Psychiatry. 2012 Apr;69(4):372-80. PMID: 22147808

Validation of diagnoses of distress disorders in the US National Comorbidity Survey Replication Adolescent Supplement (NCS-A). Green JG, Avenevoli S, Gruber MJ, Kessler RC, Lakoma MD, Merikangas KR, Sampson NA, Zaslavsky AM. Int J Methods Psychiatr Res. 2012 Mar;21(1):41-51. PMID: 22086845

Empirically derived subtypes of lifetime anxiety disorders: developmental and clinical correlates in U.S. adolescents.Burstein M, Georgiades K, Lamers F, Swanson SA, Cui L, He JP, Avenevoli S, Merikangas KR.J Consult Clin Psychol. 2012 Feb;80(1):102-15. PMID: 22081863