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Human Genetics Branch

Human Genetics Branch

About Us

Our mission is to determine the human genetic variation that contributes to the risk for mood and anxiety disorders such as bipolar disorder and panic disorder, so that better methods of diagnosis and treatment can be developed.

Recent Publications

click here for PubMed listings 

1: Cardenas SA, Kassem L, Brotman MA, Leibenluft E, McMahon FJ. Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature . Neurosci Biobehav Rev. 2016 Aug 5;69:193-215. doi: 10.1016/j.neubiorev.2016.08.002. [Epub ahead of print] Review. PubMed PMID: 27502749.

2: Hou L, Bergen SE, Akula N, Song J, Hultman CM, Landén M, Adli M, Alda M, Ardau R, Arias B, Aubry JM, Backlund L, Badner JA, Barrett TB, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Berrettini WH, Bhattacharjee AK, Biernacka JM, Birner A, Bloss CS, Brichant-Petitjean C, Bui ET, Byerley W, Cervantes P, Chillotti C, Cichon S, Colom F, Coryell W, Craig DW, Cruceanu C, Czerski PM, Davis T, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Edenberg HJ, Étain B, Falkai P, Foroud T, Forstner AJ, Frisén L, Frye MA, Fullerton JM, Gard S, Garnham JS, Gershon ES, Goes FS, Greenwood TA, Grigoroiu-Serbanescu M, Hauser J, Heilbronner U, Heilmann-Heimbach S, Herms S, Hipolito M, Hitturlingappa S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Koller DL, König B, Lackner N, Laje G, Lang M, Lavebratt C, Lawson WB, Leboyer M, Leckband SG, Liu C, Maaser A, Mahon PB, Maier W, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McInnis MG, McKinney R, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Mühleisen TW, Nievergelt CM, Nöthen MM, Novák T, Nurnberger JI Jr, Nwulia EA, Ösby U, Pfennig A, Potash JB, Propping P, Reif A, Reininghaus E, Rice J, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Scheftner WA, Schofield PR, Schork NJ, Schulze TG, Schumacher J, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Smith EN, Squassina A, Stamm T, Stopkova P, Streit F, Strohmaier J, Szelinger S, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt SH, Wright A, Zandi PP, Zhang P, Zollner S, McMahon FJ. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder . Hum Mol Genet. 2016 Jun 21. pii: ddw181. [Epub ahead of print] PubMed PMID: 27329760.

3: Geoffroy PA, Etain B, Lajnef M, Zerdazi EH, Brichant-Petitjean C, Heilbronner U, Hou L, Degenhardt F, Rietschel M, McMahon FJ, Schulze TG, Jamain S, Marie-Claire C, Bellivier F. Circadian genes and lithium response in bipolar disorders: associations with PPARGC1A (PGC-1α) and RORA . Genes Brain Behav. 2016 Jun 21. doi: 10.1111/gbb.12306. [Epub ahead of print] PubMed PMID: 27324142.

4: McMahon FJ. Genetic association studies in psychiatry: time for pay-off . Lancet Psychiatry. 2016 Apr;3(4):309-10. doi: 10.1016/S2215-0366(16)00016-X. Epub 2016 Feb 23. PubMed PMID: 26915513.

5: Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study . Lancet. 2016 Mar 12;387(10023):1085-93. doi: 10.1016/S0140-6736(16)00143-4. Epub 2016 Jan 22. PubMed PMID: 26806518; PubMed Central PMCID: PMC4814312.

6: Xu MY, Umbach DM, Murphy E, McMahon F, Shugart YY. A Novel Mixture Model to Estimate the Time to Drug Effect Onset and Its Association with Covariates . Hum Hered. 2015;80(2):90-9. doi: 10.1159/000440880. Epub 2016 Jan 16. PubMed PMID: 26771572.

7: Coryell W, Kriener A, Butcher B, Nurnberger J, McMahon F, Berrettini W, Fiedorowicz J. Risk factors for suicide in bipolar I disorder in two prospectively studied cohorts . J Affect Disord. 2016 Jan 15;190:1-5. doi: 10.1016/j.jad.2015.10.007. Epub 2015 Oct 13. PubMed PMID: 26476155.

8: McMahon FJ. Clinically Useful Genetic Markers of Antidepressant Response: How Do We Get There From Here?  Am J Psychiatry. 2015 Aug 1;172(8):697-9. doi: 10.1176/appi.ajp.2015.15050644. PubMed PMID: 26234589.

9: Akula N, Wendland JR, Choi KH, McMahon FJ. An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder . Neuropsychopharmacology. 2016 Feb;41(3):886-95. doi: 10.1038/npp.2015.218. Epub 2015 Jul 27. PubMed PMID: 26211730; PubMed Central PMCID: PMC4707835.

10: McMahon FJ. Prediction of treatment outcomes in psychiatry--where do we stand?  Dialogues Clin Neurosci. 2014 Dec;16(4):455-64. Review. PubMed PMID: 25733951; PubMed Central PMCID: PMC4336916.

11: Ament SA, Szelinger S, Glusman G, Ashworth J, Hou L, Akula N, Shekhtman T, Badner JA, Brunkow ME, Mauldin DE, Stittrich AB, Rouleau K, Detera-Wadleigh SD, Nurnberger JI Jr, Edenberg HJ, Gershon ES, Schork N; Bipolar Genome Study, Price ND, Gelinas R, Hood L, Craig D, McMahon FJ, Kelsoe JR, Roach JC. Rare variants in neuronal excitability genes influence risk for bipolar disorder . Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3576-81. doi: 10.1073/pnas.1424958112. Epub 2015 Feb 17. PubMed PMID: 25730879; PubMed Central PMCID: PMC4371952.