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Section on Neural Gene Expression

Section on Neural Gene Expression - SNGE Studies Using SNGE Knockout Mice

Studies Using SNGE Vasopressin 1b Receptor Knockout Mice

  1. Roper JA, Craighead M, O'Carroll AM, Lolait SJ.
    Attenuated Stress Response to Acute Restraint and Forced Swimming Stress in Vasopressin Avpr1b Receptor Knockout Mice and Wild Type Mice Treated with a Novel Avpr1b Receptor Antagonist.
    J Neuroendocrinol. 2010 Nov;22(11):1173-80
    PMID: 20846299
  2. Newson MJ, Roberts EM, Pope GR, Lolait SJ, O'Carroll AM.
    The effects of apelin on hypothalamic-pituitary-adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms.
    J Endocrinol. 2009 Jul;202(1):123-9. Epub 2009 Apr 24.
  3. O'Carroll AM, Howell GM, Roberts EM, Lolait SJ.
    Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells.
    J Endocrinol. 2008 May;197(2):231-9.
    PMID: 18434353
  4. Subburaju S, Aguilera G.
    Vasopressin mediates mitogenic responses to adrenalectomy in the rat anterior pituitary.
    Endocrinology. 2007 Jul;148(7):3102-10. Epub 2007 Apr 5.
    PMID: 17412807

Studies Using SNGE Oxytocin Receptor Knockout Mice

  1. Di Benedetto A, Sun L, Zambonin CG, Tamma R, Nico B, Calvano CD, Colaianni G, Ji Y, Mori G, Grano M, Lu P, Colucci S, Yuen T, New MI, Zallone A, Zaidi M.
    Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor.
    Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16502-7. doi: 10.1073/pnas.1419349111. Epub 2014 Nov 5.
    PMID: 25378700
  2. Nakajima M, Görlich A, Heintz N.
    Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons.
    Cell. 2014 Oct 9;159(2):295-305. doi: 10.1016/j.cell.2014.09.020.
    PMID: 25303526
  3. Rich ME, deCárdenas EJ, Lee HJ, Caldwell HK.
    Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice.
    PLoS One. 2014 Jun 3;9(6):e98839.
    PMID: 24892749
  4. Dölen G, Darvishzadeh A, Huang KW, Malenka RC.
    Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
    Nature. 2013 Sep 12;501(7466):179-84. doi: 10.1038/nature12518.
    PMID: 24025838
  5. Dhakar MB, Rich ME, Reno EL, Lee HJ, Caldwell HK.
    Heightened aggressive behavior in mice with lifelong versus postweaning knockout of the oxytocin receptor.
    Horm Behav. 2012 62(1):86-92. Epub 2012 May 17.
    PMID: 22609339
  6. Pobbe RL, Pearson BL, Blanchard DC, Blanchard RJ.
    Oxytocin receptor and Mecp2(308/Y) knockout mice exhibit altered expression of autism-related social behaviors.
    Physiol Behav. 2012 Dec 5;107(5):641-8. doi: 10.1016/j.physbeh.2012.02.024. Epub 2012 Mar 3
    PMID: 22406388

Studies Using SNGE Oxytocin Knockout Mice

  1. Becker RO, Dall'Oglio A, Rigatto K, Giovenardi M, Rasia-Filho AA.
    Differently shaped spines increase in the posterodorsal medial amygdala of oxytocin knockout female mice. (2015). Differently shaped spines increase in the posterodorsal medial amygdala of oxytocin knockout female mice.
    Neurosci Res. 2015 Dec;101:53-6.
    PMID: 26163772
  2. Elabd C, Cousin W, Upadhyayula P, Chen RY, Chooljian MS, Li J, Kung S, Jiang KP, Conboy IM.
    Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
    Nat Commun. 2014 Jun 10
    PMID: 24915299
  3. Zheng J-J, Li S-J, Zhang X-D., Miao W-Y. Zhang D, Yao H, & Yu X.
    Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices.
    Nat Neurosci. 2014 Mar;17(3):391-9.
    PMID: 24464043.
  4. Becker RO, Lazzari VM, Menezes IC, Morris M, Rigatto K, Lucion AB, Rasia-Filho AA, Giovenardi M.
    Sexual behavior and dendritic spine density of posterodorsal medial amygdala neurons in oxytocin knockout female mice.
    Behav Brain Res. 2013 Nov 1;256:95-100
    PMID: 23906766
  5. Lazzari VM, Becker RO, de Azevedo MS, Morris M, Rigatto K, Almeida S, Lucion AB, Giovenardi M.
    Oxytocin modulates social interaction but is not essential for sexual behavior in male mice.
    Behav Brain Res. 2013 May 1;244:130-6
    PMID: 23376700
  6. Vollmer RR, Cai HM, Miedlar JA, Amico JA.
    Voluntary Sodium Ingestion in Wild-Type and Oxytocin Knockout Mice.
    Clin Exp Hypertens. 2013;35(3):167-74
    PMID: 22784207
  7. Griffin GD, Ferri-Kolwicz SL, Reyes BA, Van Bockstaele EJ, Flanagan-Cato LM.
    Ovarian hormone-induced reorganization of oxytocin-labeled dendrites and synapses lateral to the hypothalamic ventromedial nucleus in female rats.
    J Comp Neurol. 2010 Nov 15;518(22):4531-45.
    PMID: 19653998
  8. Liu X, Shimono K, Zhu LL, Li J, Peng Y, Imam A, Iqbal J, Moonga S, Collioni G, Lu Z, Iwamoto M, Pacifici M, Zallone A, Sun L, Zaidi M.
    Oxytocin deficiency impairs maternal skeletal remodeling.
    Biochem Biophys Res Commun. 2009 Oct 9;388(1):161-6. Epub 2009 Aug 3.
    PMID: 19653998
  9. Amico JA, Miedlar JA, Cai HM, Vollmer RR.
    Oxytocin knockout mice: a model for studying stress-related and ingestive behaviours.
    Prog Brain Res. 2008;170:53-64.
    PMID: 18655871
  10. Amico JA, Cai HM, Vollmer RR.
    Corticosterone release in oxytocin gene deletion mice following exposure to psychogenic versus non-psychogenic stress.
    Neurosci Lett. 2008 Sep 19;442(3):262-6. Epub 2008 Jul 6.
    PMID: 18625285
  11. Miedlar JA, Rinaman L, Vollmer RR, Amico JA.
    Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions.
    Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1063-8. Epub 2007 Jun 27.
    PMID: 17596329
  12. Sclafani A, Rinaman L, Vollmer RR, Amico JA.
    Oxytocin Knockout Mice Demonstrate Enhanced Intake of Sweet and Non-Sweet Carbohydrate Solutions.
    Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1828-33. Epub 2007 Feb 1.
    PMID: 17272659
  13. Vollmer RR, Li X, Karam JR, Amico JA.
    Sodium ingestion in oxytocin knockout mice.
    Exp Neurol. 2006 Dec;202(2):441-8. Epub 2006 Aug 23.
    PMID: 16930592
  14. Billings LB, Spero JA, Vollmer RR, Amico JA.
    Oxytocin null mice ingest enhanced amounts of sweet solutions during light and dark cycles and during repeated shaker stress.
    Behav Brain Res. 2006 Jul 15;171(1):134-41. Epub 2006 May 4.
    PMID: 16677726
  15. Pedersen CA, Vadlamudi SV, Boccia ML, Amico JA.
    Maternal behavior deficits in nulliparous oxytocin knockout mice.
    Genes Brain Behav. 2006 Apr;5(3):274-81.
    PMID: 16594980
  16. Mantella RC, Vollmer RR, Amico JA.
    Corticosterone release is heightened in food or water deprived oxytocin deficient male mice.
    Brain Res. 2005 Oct 5;1058(1-2):56-61.
    PMID: 16168966
  17. Amico JA, Vollmer RR, Cai HM, Miedlar JA, Rinaman L.
    Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion.
    Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1798-806. Epub 2005 Sep 8.
    PMID: 16150836
  18. Rinaman L, Vollmer RR, Karam J, Phillips D, Li X, Amico JA.
    Dehydration anorexia is attenuated in oxytocin-deficient mice.
    Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1791-9. Epub 2005 Feb 17.
    PMID: 15718385
  19. Mantella RC, Vollmer RR, Rinaman L, Li X, Amico JA.
    Enhanced corticosterone concentrations and attenuated Fos expression in the medial amygdala of female oxytocin knockout mice exposed to psychogenic stress.
    Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1494-504. Epub 2004 Aug 19.
    PMID: 15319220
  20. Amico JA, Vollmer RR, Karam JR, Lee PR, Li X, Koenig JI, McCarthy MM.
    Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice.
    Pharmacol Biochem Behav. 2004 Jun;78(2):333-9.
    PMID: 15219775
  21. Bernatova I, Rigatto KV, Key MP, Morris M.
    Stress-induced pressor and corticosterone responses in oxytocin-deficient mice.
    Exp Physiol. 2004 Sep;89(5):549-57. Epub 2004 Jun 7.
    PMID: 15184356
  22. Amico JA, Mantella RC, Vollmer RR, Li X.
    Anxiety and stress responses in female oxytocin deficient mice.
    J Neuroendocrinol. 2004 Apr;16(4):319-24. Review.
    PMID: 15089969
  23. Mantella RC, Rinaman L, Vollmer RR, Amico JA.
    Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice.
    Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R1037-45.
    PMID: 14557235
  24. Rigatto K, Puryear R, Bernatova I, Morris M.
    Salt appetite and the renin-angiotensin system: effect of oxytocin deficiency.
    Hypertension. 2003 Oct;42(4):793-7. Epub 2003 Sep 2.
    PMID: 12953013
  25. Mantella RC, Vollmer RR, Li X, Amico JA.
    Female oxytocin-deficient mice display enhanced anxiety-related behavior.
    Endocrinology. 2003 Jun;144(6):2291-6.
    PMID: 12746288
  26. Amico JA, Mantella RC, Vollmer RR.
    Consumption of solutions containing sodium chloride is enhanced in female oxytocin-deficient mice.
    Behav Neurosci. 2003 Feb;117(1):32-7.
    PMID: 12619905
  27. Michelini LC, Marcelo MC, Amico J, Morris M.
    Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice.
    Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H2269-76. Epub 2003 Jan 16.
    PMID: 12531722
  28. Assinder SJ, Rezvani A, Nicholson HD.
    Oxytocin promotes spermiation and sperm transfer in the mouse.
    Int J Androl. 2002 Feb;25(1):19-27.
    PMID: 11869373
  29. Amico JA, Morris M, Vollmer RR.
    Mice deficient in oxytocin manifest increased saline consumption following overnight fluid deprivation.
    Am J Physiol Regul Integr Comp Physiol. 2001 Nov;281(5):R1368-73.
    PMID: 11641104
  30. Puryear R, Rigatto KV, Amico JA, Morris M.
    Enhanced salt intake in oxytocin deficient mice.
    Exp Neurol. 2001 Oct;171(2):323-8.
    PMID: 11573985

Studies Using SNGE Oxytocin-eGFP Transgenic Mice

  1. Atasoy D, Betley JN, Su HH, Sternson SM.
    Deconstruction of a neural circuit for hunger.
    Nature. 2012 Aug 9;488(7410):172-7.
    PMID: 22801496

Updated: 12/15/15