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Molecular Imaging Branch

Representative Publications

M. Fujita, C.S. Hines, S.S. Zoghbi, A.G. Mallinger, L.P. Dickstein, J.-S. Liow, Y. Zhang, V.W. Pike, W.C. Drevets, R.B. Innis, and C.A. Zarate Jr. Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder. Biol. Psych. 72: 548-554, 2012.

J. Hirvonen, W.C. Kreisl, M. Fujita, I. Dustin, S. Miranda, Y. Zhang, C. Morse, V.W. Pike, R.B. Innis, and W.H. Theodore. Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. J. Nucl. Med. 53: 234-240, 2012.

W.C. Kreisl, K.J. Jenko, C.S. Hines, C.H. Lyoo, W. Corona, C.L. Morse, S.S. Zoghbi, T. Hyde, J.E. Kleinman, V.W. Pike, F.J. McMahon, and R.B. Innis. A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J. Cereb. Blood Flow Metab. 33: 53-58, 2013.

W.C. Kreisl, C.H. Lyoo, M. McGwier, J. Snow, K.J. Jenko, N. Kimura, W. Corona, C.L. Morse, S.S. Zoghbi, V.W. Pike, F.J. McMahon, R.S. Turner, R.B. Innis, and the Biomarkers Consortium PET Radioligand Project Team. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease. Brain, 136: 2228-2238, 2013

S. Shrestha, E.E. Nelson, J.-S. Liow, R. Gladding, C.H. Lyoo, P.L. Noble, C. Morse, I.D. Henter, J. Kruger, B. Zhang, S.J. Suomi, P. Svenningsson, V.W. Pike, J.T. Winslow, E. Leibenluft, D.S. Pine, and R.B Innis. Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior. Am. J. Psychiatry. Jan 31, 2014 [Epub ahead of print]

W.C. Kreisl, C.H. Lyoo, J.-S. Liow, M. Wei, J. Snow, E. Page, K.J. Jenko, C.L. Morse, S.S. Zoghbi, V.W. Pike, R.S. Turner, and R.B. Innis. 11C-PBR28 binding to translocator protein increases with progression of Alzheimer’s disease. Neurobiology of Aging, 44: 53-61, 2016.

M. Ikawa, T.G. Lohith, S. Shrestha, S. Telu, S.S. Zoghbi, S. Castellano, S. Taliani, F. Da Settimo, M. Fujita, V.W. Pike, and R.B. Innis. 11C-ER176, a radioligand for 18 kDa translocator protein (TSPO), is adequately sensitive for robust imaging of all three affinity genotypes in human brain. J. Nucl. Med. In Press.

M. Fujita, E.M. Richards, M. Niciu, S.S. Zoghbi, J. Hong, S. Telu, C.S. Hines, V.W. Pike, C.A. Zarate Jr, and R.B. Innis. cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor. Mol. Psychiatry. In press.