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Molecular Imaging Branch

2013 Publications

Full Refereed Papers

1. Chun JH, Pike VW, Single-step syntheses of no-carrier-added functionalized [18F]fluoroarenes as labeling synthons from diaryliodonium salts, Org. Biomol. Chem., 2013, 11, 6300-6306.[DOI: 10.1039/c3ob41353e, PMID:23942997]

2. Chun JH, Morse CL, Chin FT, Pike VW, No-carrier-added [F-18]fluoroarenes from the radiofluorination of diaryl sulfoxides, Chem. Commun., 2013, 49, 2151-2153.   [DOI: 10.1039/c3cc37795d, PMID:23388835]   

3. Chun JH, Telu S, Lu SY, Pike VW, Radiofluorination of diaryliodonium tosylates under aqueous–organic and cryptand-free conditions, Org. Biomol. Chem., 2013, 11, 5094–5099.  [DOI: 10.1039/c3ob40742j, PMID:23804017]

4. Hirvonen J, Zanotti-Fregonara P, Umhau JC, George DT, Rallis-Frutos D, Lyoo CH, Li CT, Hines CS, Sun H, Terry GE, Morse C, Zoghbi SS, Pike VW, Innis RB, Heilig M, Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography, Mol. Psych., 2013, 18, 916-921. [DOI: 10.1038/mp.2012.100]

5. Kreisl WC, Lyoo CH, McGwier M, Snow J, Jenko KJ, Kimura N, Corona W, Morse CL, Zoghbi SS, Pike VW, McMahon FJ, Turner RS, Innis RB, In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease, Brain, 2013, 136, 2228-2238.   [DOI: 10.1093/brain/awt145, PMID:23775979]

6. Kannan P, Pike VW, Halldin C, Langer O, Gottesman MM, Innis RB, Hall MD, Factors that limit positron emission tomography imaging of P-glycoprotein density at the blood-brain barrier, Mol. Pharm., 2013, 10, 2222-2229.   [DOI: 10.1021/mp400011g, PMID:23597242]

7. Zanotti-Fregonara P, Hirvonen J, Lyoo CH, Zoghbi SS, Rallis-Frutos D, Huestis MA, Morse C, Pike VW, Innis RB, Population-based input function modeling for [F-18]FMPEP-d2, an inverse agonist radioligand for cannabinoid CB1 receptors: Validation in clinical studies, PLOS ONE, 2013, 8, Article Number: e60231.   [DOI: 10.1371/journal.pone.0060231, PMID:23577094]

8. Mathe D, Horvath I, Szigeti K, Donohue SR, Pike VW, Jia ZS, Ledent C, Palkovits M, Freund TF, Halldin C, Gulyas B,In vivo SPECT and ex vivo autoradiographic brain imaging of the novel selective CB1 receptor antagonist radioligand [I-125]SD7015 in CB1 knock-out and wildtype mouse, Brain Res. Bull., 2013, 91, 46-51.   [DOI: 10.1016/j.brainresbull.2013.01.001, PMID:23318272]

9. Hines CS, Fujita M, Zoghbi SS, Kim JS, Quezado Z, Herscovitch P, Miao N, Araneta MDF, Morse C, Pike VW, Labovsky J, Innis RB, Propofol decreases in vivo binding of C-11-PBR28 to translocator protein (18 kDa) in the human brain, J. Nucl. Med., 2013, 54, 64-69.   [DOI: 10.2967/jnumed.112.106872, PMID:23148296]

10. Kreisl WC, Jenko KJ, Hines CS, Lyoo CH, Corona W, Morse CL, Zoghbi SS, Hyde T, Kleinman JE, Pike VW, McMahon FJ, Innis RB, A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation, J. Cereb. Blood Flow metab., 2013, 33, 53-58. [DOI: 10.1038/jcbfm.2012.131, PMID:22968319]

11. Zanotti-Fregonara P, Barth VN, Liow JS, Zoghbi SS, Clark DT, Rhoads E, Siuda E, Heinz BA, Nisenbaum E, Dressman B, Joshi E, Luffer-Atlas D, Fisher MJ, Masters JJ, Goebl N, Kuklish SL, Morse C, Tauscher J, Pike VW, Innis RB, Evaluation in vitro and in animals of a new C-11-labeled PET radioligand for metabotropic glutamate receptors 1 in brain, Eur. J. Nucl. Med. Mol. Imag., 2013, 40, 245-253. [DOI: 10.1007/s00259-012-2269-7, PMID:23135321]

12. Paterson LM, Kornum BR, Nutt DJ, Pike VW, Knudsen GM, 5-HT radioligands for human brain imaging with PET and SPECT, Med. Res. Rev., 2013, 33, 54-111. [DOI: 10.1002/med.20245]

13. Zanotti-Fregonara P, Barth VN, Zoghbi SS, Liow JS, Nisenbaum E, Siuda E, Gladding RL, Rallis-Frutos D, Morse C, Tauscher J, Pike VW, Innis RB, 11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains, EJNMMI Res., 2013, 3, 47.   [doi:10.1186/2191-219X-3-47, PMID:23758896]

14. Fujita M, Mahanty S, Zoghbi SS, Araneta MDF, Hong J, Pike VW, Innis RB, Nash TE, PET Reveals inflammation around calcified taenia solium granulomas with perilesional Edema, PLOS ONE, 2013, 8, Article Number: e74052. [DOI: 10.1371/journal.pone.0074052, PMID:24058514]

15. Xu R, Zanotti-Fregonara P, Zoghbi SS, Gladding RL, Woock A, Innis RB, Pike VW, Synthesis and Evaluation in Monkey of [18F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([18F]FIMX), a Promising Radioligand for PET Imaging of Brain Metabotropic Glutamate Receptor 1 (mGluR1), J. Med. Chem. 2013, 56, 9146-9155.  [DOI: 10.1021/jm4012017, PMID:24147864]

16. Shetty HU, Morse CL, Zhang Y, Pike VW, Characterization of fast-decaying PET radiotracers solely through LC-MS/MS of constituent radioactive and carrier isotopologues, EJNMMI Res., 2013, 3, 3. [doi: 10.1186/2191-219X-3-3, PMID:23311872]