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Molecular Imaging Branch

2.9 Solid phase radiochemistry

2 Research Method Development

2.9 Solid phase radiochemistry

Figure 4: Radiofluorination via NALG.In collaboration with Dr. S. Lepore (Florida Atlantic U.) we are developing novel arylsulfonate-based nucleophilic assisted leaving groups (NALGs) that in non-radioactive work show remarkable rateenhancement in nucleophilic displacement reactions.56 This approach should be useful for the development of efficient resin-supported [18F]fluoridation with the advantage of ease of radioactive product separation (Figure 4).