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Behavioral Neuroscience

Photo of Gloria Laryea

Postdoctoral Fellow
gloria.laryea@nih.gov

B.Sc. (Hons), University of Maryland Eastern Shore, MD
Ph.D. Neuroscience, Vanderbilt University, Nashville, TN

+1 301 496 7522

Gloria Laryea received her B.Sc (Hons) in Biology from the University of Maryland Eastern Shore, MD in 2008. She went on to obtain her PhD in 2014 under the mentorship of Dr. Louis Muglia at Vanderbilt University where she studied the molecular neurobiology of the stress response and its consequent maladaptive behavior. She joined the Chudasama lab at NIMH in Feb 2016 as postdoctoral fellow interested in studying the neural circuitry governing cognitive and executive function as it relates to complex human behavior, thus examining how dysfunction in these circuits affect neurological and neuropsychiatric disorders. In addition to her scientific interest, Dr. Laryea enjoys trying out new recipes and urban music and dance.

Peer-Reviewed Papers

Arnett MG, Muglia LM, Laryea G, Muglia LJ. Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation. Neuropsychopharmacology. 2016 Jan;41(1):245-60. PMID: 26189452.

Laryea G, Arnett M, Muglia LJ. Ontogeny of hypothalamic glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in mice. Stress. 2015;18(4):400-7. PMID: 26068518.

Kong F, Laryea G, Liu Z, Bhattacharyya S. Transforming growth factor-β-activated kinase 1 resistance limits glucocorticoid responsiveness to Toll-like receptor 4-mediated inflammation. Immunology. 2015 May;145(1):136-49. PMID: 25521315.

Laryea G, Muglia L, Arnett M, Muglia LJ. Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice. Front Neuroendocrinol. 2015 Jan;36:150-64. PMID: 25256348.

Kocalis HE, Hagan SL, George L, Turney MK, Siuta MA, Laryea GN, Morris LC, Muglia LJ, Printz RL, Stanwood GD, Niswender KD. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Mol Metab. 2014 Jul;3(4):394-407. PMID: 24944899.

Laryea G, Schütz G, Muglia LJ. Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity. Mol Endocrinol. 2013 Oct;27(10):1655-65. PMID: 23979842.

Laryea G, Arnett MG, Wieczorek L, Muglia LJ. Site-specific modulation of brain glucocorticoid receptor and corticotropin-releasing hormone expression using lentiviral vectors. Mol Cell Endocrinol. 2013 May 22;371(1-2):160-5. PMID: 23261985.

Laryea G, Arnett MG, Muglia LJ. Behavioral Studies and Genetic Alterations in Corticotropin-Releasing Hormone (CRH) Neurocircuitry: Insights into Human Psychiatric Disorders. Behav Sci (Basel). 2012 Jun 21;2(2):135-71. PMID: 23077729.

Kocalis HE, Turney MK, Printz RL, Laryea GN, Muglia LJ, Davies SS, Stanwood GD, McGuinness OP, Niswender KD. Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity. PLoS One. 2012;7(8):e42981. PMID: 22916190.

Lathia JD, Okun E, Tang SC, Griffioen K, Cheng A, Mughal MR, Laryea G, Selvaraj PK, ffrench-Constant C, Magnus T, Arumugam TV, Mattson MP. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. J Neurosci. 2008 Dec 17;28(51):13978-84. PMID: 19091986.

Presentations

Laryea Gloria, Muglia Louis J. (2014). Ontogeny of hypothalamic-pituitary-adrenal axis after hypothalamic glucocorticoid receptor disruption. Neurobiology of Stress Workshop, Cincinnati, OH

Laryea Gloria, Muglia Louis J. (2012). Tetracycline-regulated CRH expression in Transgenic Mice as a Model for Isolating Brain-Region Specific Function in the Stress Response. HHMI/VUMC Certificate Program in Molecular Medicine Retreat, Nashville, TN

Laryea Gloria, Muglia Louis J. (2011). Deletion of the glucocorticoid receptor in Sim1-expressing neurons alters HPA axis regulation and causes a Cushingoid phenotype. Vanderbilt University Neuroscience Retreat, Nashville, TN

Laryea, Gloria. (2011). The role of corticotropin-releasing hormone in the central nucleus of the amygdala in stress signaling.Vanderbilt University Neuroscience Retreat, Nashville, TN (Oral Presentation)

Laryea Gloria, Muglia Louis J. (2010). Tetracycline-regulated CRH expression in Transgenic Mice as a Model for Isolating Brain-Region Specific Function in the Stress Response. Society for Neuroscience, San Diego, CA