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Section on Neurobiology of Fear and Anxiety

CV of Nicholas L. Balderston

Nicholas L. Balderston

EDUCATION

University of West Florida
B.A. in Psychology 2004

University of Wisconsin-Milwaukee
M.S. in Experimental Psychology - Neuroscience 2010
Title: The effect of CS-UCS interval on masked conditioning with fear-relevant and fear- irrelevant stimuli.
Committee: Fred Helmstetter PhD.; Christine Larson, PhD.; Anthony Greene, PhD.

University of Wisconsin-Milwaukee
PhD in Experimental Psychology - Neuroscience 2013
Title: Neural responses during trace conditioning with face and non-face stimuli recorded with magnetoencephalography
Committee: Fred Helmstetter PhD.; Christine Larson, PhD.; Ira Driscoll, PhD.; Deborah Hannula, PhD.; Catherine Tallon-Baudry, PhD.
Advisor: Dr. Fred Helmstetter PhD.
Major: Neuroscience
Minor: Neurobiology, Behavior Analysis

École normale supérieure
Chateaubriand Fellow 2012
Advisor: Dr. Catherine Tallon-Baudry

PUBLICATIONS

Balderston, N. L., & Helmstetter, F. (2010). Conditioning with masked stimuli and without awareness affects timecourse of skin conductance response. Behavioral Neuroscience, 123(4), 478-489.

Balderston, N. L., Schultz, D. H., & Helmstetter, F. (2011). The human amygdala plays a stimulus specific role in the detection of novelty. Neuroimage, 55(4), 1889-1898.

Balderston, N. L., Schultz, D. H., & Helmstetter, F. (2013). The effect of threat on novelty evoked amygdala responses. PLoS ONE 8(5): e63220.

Balderston, N. L., Schultz, D. H., Baillet, S., & Helmstetter, F. (2013). How to detect amygdala activity with magnetoencephalography using source imaging, Journal of Visualized Experiments. 76 http://www.jove.com/video/50212/how-to-detect-amygdala-activity- with-magnetoencephalography-using?status=a52218k

Balderston, N. L., Schultz, D. H., Baillet, S., & Helmstetter, F. J. (2014). Rapid amygdala responses during trace fear conditioning without awareness. PloS One, 9(5),

Balderston, N. L., Schultz, D. H., Hopkins, L., & Helmstetter, F. (In Press). Identification of distinct functional subregions of the human amygdala using high-resolution BOLD imaging and probabilistic tractography. Social Cognitive and Affective Neuroscience

Balderston, N. L., Mathur, A., Adu-Brimpong, J., Hale, E. A., Ernst, M., Grillon, C. (2015). Effect of anxiety on behavioural pattern separation in humans. Cognition and Emotion. doi: 10.1080/02699931.2015.1096235

Balderston, N. L., O’Connell, K., Vytal, K., Torrisi, S., Letkiewicz, A., Ernst, M., & Grillon, C. (2016). ANXIETY PATIENTS SHOW REDUCED WORKING MEMORY RELATED DLPFC ACTIVATION DURING SAFETY AND THREAT. 1-12. DOI: 10.1002/da.22518

S Torrisi, K O’Connell, A Davis, R Reynolds, N Balderston, JL Fudge, C Grillon, M Ernst. (2015) Resting State Connectivity of the Bed Nucleus of the Stria Terminalis at Ultra-high Field. Human Brain Mapping, 36 4076–4088

Schultz, D. H., Balderston, N. L., & Helmstetter, F. J. (2012). Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning. Frontiers in Human Neuroscience, 6(August), 1–10.

Schultz, D. H., Balderston, N. L., Geiger, J. A., & Helmstetter, F. J. (2013). Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans. Behavioral Neuroscience, 127(3), 357-368.

Larson, C. L., Baskin-Sommers, A. R., Stout, D. M., Balderston, N. L., Curtin, J. J., Schultz

D. H., Kiehl, K. A., & Newman, J. P. (2013), The interplay of attention and emotion: top-down attention modulates amygdala activation in psychopathy. Cognitive, Affective, & Behavioral Neuroscience, 1-14.

REVIEWS AND CHAPTERS

Gilmartin, M. R., Balderston, N. L., & Helmstetter, F. J. (2014). Prefrontal cortical regulation of fear learning. Trends in Neurosciences, 37(8), 455–464.

Ernst, M., Torrisi, S., Balderston, N. L., Grillon, C., & Hale, E. a. (2014). fMRI Functional Connectivity Applied to Adolescent. Annual Review of Clinical Psychology, (December), 1– 17. doi:10.1146/annurev-clinpsy-032814-112753

Ernst, M., Hale E. A., Torrisi, S., & Balderston, N. L. (2014). Introduction to functional brain connectivity and potential contributions to understanding adolescent vulnerability to substance abuse. Chapter in Neuroimaging and Psychosocial Addiction Treatment

IN PREPARATION

Balderston, N. L., Helmstetter, F., & Tallon-Baudry, C. (In preparation) Coordinated medial temporal lobe and prefrontal cortex activity mediates trace fear conditioning.

Balderston, N. L., Quispe-Escudero, D., Hale, E., Davis, A., O’connell, K., Ernst, M., Grillon,

C. (In preparation). The effect of working memory load on anxiety potentiated startle.

S Torrisi, O Robinson, K O’Connell, A Davis, N Balderston, M Ernst, C Grillon. (submitted) The Neural Basis of Improved Cognitive Performance by Threat of Shock.

Schultz, D. H., Balderston, N. L., Cheng, D., Geiger, J. A., & Helmstetter, F. (In preparation). Conditional stimulus BOLD activation overlaps with shock evoked activity in somatosensory cortex.

Schultz, D., Balderston, N. L., & Helmstetter, F. (In preparation). A direct comparison of auditory and visual fear conditioning in humans using FMRI.

Balderston, N. L., Schultz D. H., Baskin-Sommers, A. R., Newman, J. P. Larson, C. L., & Helmstetter, F (In preparation). Psychopaths display greater amygdala activation in a basic conditioning paradigm.

ABSTRACTS

Balderston, N. L., Hale, L., Torrisi, S., Hsiung, A., O’Connell, K., Ernst, M., & Grillon, C. The effect of threat on within-network functional connectivity across the entire human brain. Program. No. 109.09. 2015 Neuroscience Meeting Planner. Chicago, Il: Society for Neuroscience, 2015. Online

Balderston, N. L., Hale, L., Torrisi, S., O’Connell, K., Ernst, M., & Grillon, C. Resting State Alpha Oscillations in the Expression of Anxiety-potentiated Startle. (2015). Poster presented at the Society for Biological Psychiatry meeting in Toronto, Canada.

Balderston, N. L., Hale, L., Torrisi, S., O’Connell, K., Ernst, M., & Grillon, C. Anxiety interferes with brain activity at rest. (2015). Poster presented at the Madison Symposium on Emotion in Madison, WI.

Balderston, N. L., O’Connell, K., Vytal, K., Torrisi, S., Ernst, M., & Grillon, C. Anxiety impairs performance and reduces dlPFC activity during high load spatial working memory. Program. No. 836.06. 2014 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2014. Online

Balderston, N. L., Helmstetter, F., & Tallon-Baudry, C. Neural sources of delay and trace fear conditioning recorded with magnetoencephalography. Program. No. 182.12. 2014 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2013. Online

Balderston, N. L., Schultz, D., & Helmstetter, F. Using DTI and high resolution BOLD to identify distinct functional subunits of the human amygdala. Program. No. 493.02. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online

Balderston, N. L., Schultz, D., Baillet, S., & Helmstetter, F. (2012). Rapid amygdala responses during trace fear conditioning without awareness. Poster presented at the Organization for Human Brain Mapping meeting in Beijing, China.

Balderston, N. L., Schultz, D., Newman, J. P., Larson, C. L., & Helmstetter, F. (2012). Behavioral and amygdala BOLD responses in psychopaths during fear conditioning. Poster presented at the Organization for Human Brain Mapping meeting in Beijing, China.

Balderston, N. L., Schultz, D., Baillet, S., & Helmstetter, F. Neuromagnetic amygdala responses during trace fear conditioning without awareness. Program. No. 287.04. 2011 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011. Online

Balderston, N. L., Schultz, D., & Helmstetter, F. The effect of threat on novelty evoked amygdala responses. Program. No. 602.13. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online

Balderston, N. L., Schultz, D., & Helmstetter, F. Novel faces but not scenes drive BOLD responses in the amygdala. Program. No. 674.22. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2009. Online

Balderston, N. L., Schultz, D., & Helmstetter, F. (2009). BOLD response to novelty in the human amygdala. Poster presented at the Organization for Human Brain Mapping meeting in San Francisco, CA.

Balderston, N. L., Schultz, D., Schramm, C., & Helmstetter, F. In a direct comparison of novelty and emotional valence, novelty evokes larger magnitude BOLD responses in the amygdala. Program. No. 119.6. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online

Balderston, N.L., Geiger, J. A., Schultz, D.H., Helmstetter, F. J. Masked presentation of simple visual stimuli and learning without awareness in human fear conditioning Program. No. 526.19. 2007 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2007. Online

Balderston, N.L., Geiger, J. A., Schultz, D.H., Helmstetter, F. J. (2007). Learning without awareness in human fear conditioning. Poster presented at the Pavlovian Society meeting in Austin, TX.

COLLOQUIA AND SYMPOSIA

Rapid amygdala responses during trace fear conditioning without awareness. Brainstorm User Symposium at BioMag 2012. Paris, France. August 2012.

Differential effects of novelty and fear on activity within anatomically defined subregions of the human amygdala. Graduate Student Research Symposium. University of Wisconsin – Milwaukee, Milwaukee, WI. April 2012.

Novel Stimuli Evoke BOLD Responses in the Human Amygdala. Center for Imaging Research seminar series. Medical College of Wisconsin Milwaukee, WI. April 2010.

BOLD response to novelty in the human amygdala. Graduate Student Research Symposium.

University of Wisconsin – Milwaukee, Milwaukee, WI. April 2010.

BOLD response to novelty in the human amygdala. Neuroscience and Physiology seminar series. University of Wisconsin-Milwaukee, Milwaukee, WI. April 2010.

BOLD response to novelty in the human amygdala. Milwaukee Area Neuroscience Meeting.

University of Wisconsin-Milwaukee, Milwaukee, WI. April 2010.

BOLD response to novelty in the human amygdala. Milwaukee Area Neuroscience Meeting.

University of Wisconsin-Milwaukee, Milwaukee, WI. March 2010.

The effects of novelty and emotional valence on BOLD activity in the amygdala, hippocampus, and visual cortex. Neuroscience and Physiology seminar series. University of Wisconsin-Milwaukee, Milwaukee, WI. December 2008.

Masking blocks contingency awareness but not implicit learning in fear conditioning. Graduate Student Research Symposium. University of Wisconsin – Milwaukee, Milwaukee, WI. April 2008.

Fear learning does not depend on awareness. Neuroscience and Physiology seminar series.

University of Wisconsin-Milwaukee, Milwaukee, WI. November 2007.

The role of awareness in fear acquisition. Graduate Student Research Symposium.

University of Wisconsin – Milwaukee, Milwaukee, WI. April 2007.

The effects of visual masking on fear acquisition. Neuroscience and Physiology seminar series. University of Wisconsin-Milwaukee, Milwaukee, WI. April 2007.

PROFESSIONAL EXPERIENCE

Postdoctoral Fellow: National Institute of Mental Health Spring 2014 Advisor: Christian Grillon Teaching Assistant: University of Wisconsin-Milwuakee

Fall 2006 Physiological Psychology (David Bauer, M.S.) Spring 2007 Research Methods (Dr. Bob Hessling)

Fall 2007 Research Methods (Dr. Susan Lima) Spring 2008 Research Methods (Dr. Marcellus Merritt) Fall 2009 Research Methods (Dr. Susan Lima)

Research Assistant: University of Wisconsin-Milwuakee

2006-2013 Psychology Department (Dr. Fred Helmstetter)

Project Coordinator: University of West Florida

Summer 2006 Health Psychology Research Lab (Dr. Susan Walch)

Research Assistant: University of West Florida

Fall 2005 Center for Environmental Diagnostics and Bioremediation (Dr. Carl Mohrherr)

AWARDS

Chancellor’s Graduate Student Award – University of Wisconsin-Milwaukee, 2006-2008 University of Wisconsin-Milwaukee Graduate School Travel Award, 2007

John and Lynn Schiek Award in Behavior Analysis, 2009, 2010 Chateaubriand Fellowship, 2012

Madison Symposium on Emotion Travel Award, 2014

MEMBERSHIPS

Society for Neuroscience Society for Biological Psychiatry Human Brain Mapping Pavlovian Society

Sigma Xi

REVIEWER

Neuroimage

Human Brain Mapping

Journal of Psychiatry and Neuroscience Neurobiology of Learning and Memory Cognition and Emotion