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Section on Neurobiology of Fear and Anxiety

Selected Publications

Torrisi, S. J., Robinson, O., O'Connell, K., Davis, A., Balderston, N., Ernst, M., & Grillon, C. (2016). The neural basis of improved cognitive performance by threat of shock. Social Cognitive and Affective Neuroscience.

Balderston, N., Vytal, K. E., O'Connell, K., Torrisi, S. J., Letkiewicz, A., Ernst, M., et al. (2016). Anxiety Patients Show Reduced Working Memory Related DLPFC Activation During Safety and Threat. Depression and Anxiety, 1–12.

Ernst, M., Torrisi, S. J., Balderston, N., Grillon, C., & Hale, E. A. (2015). fMRI Functional Connectivity Applied to Adolescent Neurodevelopment*. Annual Review of Clinical Psychology, 11(1), 361–377. http://doi.org/10.1146/annurev-clinpsy-032814-112753

Grillon C, Hale E, Lieberman L, Davis A, Pine DS, Ernst M. (2015). The CRH1 antagonist GSK561679 increases human fear but not anxiety as assessed by startle. Neuropsychopharmacol 40: 1064-71. http://dx.doi.org/10.1038/npp.2014.316

Robinson OJ, Lieberman L, Allen P, Vytal K, Grillon C. (2015). The dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit in unmedicated generalized and social anxiety disorders. The Lancet Psychiatry 1: 294-302. http://dx.doi.org/10.1016/s2215-0366(14)70305-0

Torrisi, S. J., O'Connell, K., Davis, A., Reynolds, R., Balderston, N., Fudge, J. L., et al. (2015). Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. Human Brain Mapping, 36(10), 4076–4088. http://doi.org/10.1002/hbm.22899

Vytal, K. E., Overstreet, C., Charney, D. R., Robinson, O. J., & Grillon, C. (2014). Sustained anxiety increases amygdala–dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults. Journal of Psychiatry & Neuroscience: JPN, 39(4), 130145. http://doi.org/10.1503/jpn.130145

Robinson, O. J., Vytal, K. E., Cornwell, B. R., & Grillon, C. (2013). The impact of anxiety upon cognition: perspectives from human threat of shock studies. Frontiers in Human Neuroscience, 7, 1–21. http://journal.frontiersin.org/article/10.3389/fnhum.2013.00203/full

Schmitz, A., & Grillon, C. (2012). Assessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test). Nature Protocols, 7(3), 527–532. http://doi.org/10.1038/nprot.2012.001

Alvarez, R. P., Chen, G., Bodurka, J., Kaplan, R., & Grillon, C. (2011). Phasic and sustained fear in humans elicits distinct patterns of brain activity. NeuroImage, 55(1), 389–400. http://doi.org/10.1016/j.neuroimage.2010.11.057

Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010). Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety. Neuropsychopharmacology, 35(1), 105–135. http://doi.org/10.1038/npp.2009.109