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Section on Neuroadaptation and Protein Metabolism

Section on Neuroadaptation and Protein Metabolism (SNPM)

The mission of the Section on Neuroadaptation and Protein Metabolism (SNPM) is to study the role of protein metabolism in adaptive responses of the nervous system. Long-term changes in the nervous system occur during development and aging, in response to synaptic activity and hormones, and as a result of disease or injury. These changes produce regional adjustments in protein metabolism that underlie growth, remodeling, degeneration, regeneration, and involution. We have developed imaging methods for measuring rates of synthesis of proteins in all regions of the brain simultaneously. Our methods can be applied to studies of both animals and human subjects. Measurements of protein synthesis can give a unique window into the normal adaptive responses of nervous tissue and may provide a means of monitoring both disease progression and treatment response.