Sleep disorders are a prominent component of neurodevelopmental disorders such as autism, FXS, and TSC. In autism, the presence of sleep problems correlates with severity of symptoms. Moreover, it is increasingly clear that sleep has important roles in brain development and plasticity. In normally developing children, as well as those with neurodevelopmental disorders, acute sleep loss can result in behavior and attention problems as well as disturbances of mood. We are interested the role of disturbances in sleep on the development of brain disorders.
Our studies address:
- The presence of sleep abnormalities in mouse models of neurodevelopmental disorders
- The role of sleep restriction in mice during development on behavior in adulthood