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Transgenic Core Facility

Publications

Jinde S, Zsiros V, Jiang Z, Nakao K, Pickel J, Kohno K, Belforte JE, Nakazawa K.
Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation.
Neuron. 2012 Dec20;76(6):1189-200. doi:10.1016/j.neuron.2012.10.036. PubMed PMID: 23259953;PubMed Central PMCID .

Bharti K, Gasper M, Ou J, Brucato M, Clore-Gronenborn K, Pickel J, Arnheiter H.
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.
PLoS Genet. 2012 Jul;8(7):e1002757. doi: 10.1371/journal.pgen.1002757. Epub 2012 Jul 5. PubMed PMID: 22792072; PubMed

Cifani C, Koya E, Navarre BM, Calu DJ, Baumann MH, Marchant NJ, Liu QR, Khuc T, Pickel J, Lupica CR, Shaham Y, Hope BT.
Medial prefrontal cortex neuronal activation and synaptic alterations after stress-induced reinstatement of palatable food seeking: a study using c-fos-GFP transgenic female rats.
J Neurosci. 2012 Jun 20;32(25):8480-90. doi: 10.1523/JNEUROSCI.5895-11.2012. PubMed PMID: 22723688;

Liu J, Zhou L, Xiong K, Godlewski G, Mukhopadhyay B, Tam J, Yin S, Gao P, Shan X, Pickel J, Bataller R, O'Hare J, Scherer T, Buettner C, Kunos G.
Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. Gastroenterology. 2012 May;142(5):1218-1228.e1. doi: 10.1053/j.gastro.2012.01.032. Epub 2012 Jan 31. PubMed PMID: 22307032; PubMed Central PMCID: PMC3482511

Debbache J, Zaidi MR, Davis S, Guo T, Bismuth K, Wang X, Skuntz S, Maric D, Pickel J, Meltzer P, Merlino G, Arnheiter H.
In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor.
Genetics. 2012 May;191(1):133-44. doi: 10.1534/genetics.111.135996. Epub 2012 Feb 23. PubMed PMID: 22367038; PubMed Central PMCID: PMC3338255.

Choi KY, Chang K, Pickel JM, Badger JD 2nd, Roche KW.
Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15219-24. doi: 10.1073/pnas.1107304108. Epub 2011 Sep 6. PubMed PMID: 21896768; PubMed Central PMCID: PMC3174576.

Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA.
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature. 2011 Aug 3;476(7361):458-61. doi: 10.1038/nature10287. PubMed PMID: 21814201; PubMed Central PMCID: PMC3162077.

Tam J, Vemuri VK, Liu J, B√°tkai S, Mukhopadhyay B, Godlewski G, Osei-Hyiaman D, Ohnuma S, Ambudkar SV, Pickel J, Makriyannis A, Kunos G.
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest. 2010 Aug;120(8):2953-66. doi: 10.1172/JCI42551. Epub 2010 Jul 26. Erratum in: J Clin Invest. 2010 Oct 1;120(10):3735. PubMed PMID: 20664173; PubMed Central PMCID: PMC2912197.

Chon-Hwa Tsai Morris. Sheng Y, Gutti R, Li J, Pickel J, Dafau M.
Gonadotropin regulated testicular RNA helicase (GRTH/DDX25) gene: cell specific expression and transcriptional regulation by androgen in transgenic mouse testis.
J Cell Biochem. 2010 Apr 15;109(6):1142-7. doi: 10.1002/jcb.22493. PubMed PMID: 20108248.

Jiang Z, Belforte J, Lu Y, Yabe Y, Pickel J, Smith C, Je H-S, Lu B, Nakazawa K
Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.
J Neurosci. 30(7):2582-2594. (2010)

Shneider NA, Brown MN, Smith CA, Pickel J, Alvarez FJ
Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival.
Neural Dev. 2;4:42. (2009)

Atkin S, Patel S, Kocharyan, A, Holzclaw L, Weerth S, Schram V, Pickel J, Russell J
Transgenic mice expressing a chameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo.
J Neuroci Meth 181: 212-226. (2009)

Micseny MC, Dobrenis K, Stepheny G, Pickel J, Vanier MT, Slaugenhaupt SA, Walkley SU (2009) Neuropathology of the Mcoln1 -/- knockout mouse model of mucolipidosis type IV.
J Neuropath Exp Neurol 68(2): 125-135. (2009)

Fegley DB, Holmes A, Riordan T, Faber CA, Weiss JR, Ma S, Batkai S, Pacher P, Murphy A, Sleeman MW, Usdin TB
Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues
Genes Brain Behav 7(8):933-42. (2008)

Papaleo F, Crawley JN, Song J, Lipska BK, Pickel J, Weinberger ER, Chen J
Genetic dissection of the role of catechol-O-methlytransferase in cognition and stress reactivity in mice.
J Neurosci 28:8709-23. (2008)

Venugopal B, Browning MF, Curcio-Morelli C, Varro A, Michaud N, Wlakley SU, Pickel J, Slaugenhaupt SA
Neruologic, gastric and ophthalmologic pathologies of a murine model of mucolipidosis type IV.
Am J Hum Genet. 81:1070-83. (2007)

Bratiincsak A, Brownstein MJ, Cassiani-Ignoni R, Pastorino S, Szalayova I, Toth ZE, Key S, Nemeth K, Pickel J, Mezey E
CD45-positive blood cells give rise to uterine epithelial cells in mice.
Stem Cells 25:2820-6. (2007)

Hims MM, Shetty RS, Pickel J, Mull J, Leyne M, Liu L, Gusella JF, Slaugenhaupt SA
A humanized IKBKAP transgenic mouse models a tissue-specific human splice defect.
Genomics 90: 389-396. (2007)

Kim T, Zhang C-f, Sun Z, Wu H and Loh P
Chromogranin A deficiency iin transgenic mice leads to aberrant chromoffin granule biogenesis
J Neurosci 25: 6958-6961 (2005)

Orlic D, Kajstua J, Chimeniti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A and Anversa P.
Bone marrow cells regenerate infracted myocardium
Nature 410(6829):701-5 (2001)

Panchision DM, Pickel JM, Studer, L, Lee SH, Turner PA, Hazel TG and McKay RD
Sequential action of BMP receptors control neural precursor cell production and fate.
Genes Dev. 15 (16):2094-110 (2001)
http://www.genesdevorg/cgi/content/full/15/16/2094

Josephson R, Muller T, Pickel J, Okabe S, Reynolds K, Turner PA, Zimmer A and McKay RD
POU transcription factors control expression of CNS stem cell-specific genes
Development 125(16):3087-100 (1998)
http://dev.biologists.org/content/125/16/3087