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Multimedia About Basic Research

One Mother’s Story

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Circuit Tweak Boosts Social Memory in Mice

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iPS Cells & Organoids - Sci-Fi vs Reality

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Follow That Cell Prize Winners

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BRAIN Initiative as Moonshot

Frame from the video BRAIN Initiative as Moonshot.

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Much more extraordinary than anything we can imagine

Frame from the video Much more extraordinary than anything we can imagine.

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Follow That Cell

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Unearthing Secrets of New Neurons

Frame from the video Unearthing Secrets of New Neurons.

Heather Frank, then a senior majoring in neuroscience at Colgate University, explains studies on neurogenesis that she worked on during an internship in the NIMH Unit on Neuroplasticity.

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Channel Makover Switches Off Neurons in a Flash

Frame from the video Channel Makover Switches Off Neurons in a Flash.

Scientists have bioengineered an enhancement to a cutting edge technology that provides instant control over brain circuit activity with a flash of light. The research adds the same level of control over switching neurons off that, until now, had been limited to switching them on. What had been working through a weak pump now works through a highly responsive channel -- like going from a squirt to a gushing hose. Project officer Michelle Freund, Ph.D., of the NIMH Office of Technology Development and Coordination, explains the significance of the new findings.

See: Channel Makeover Bioengineered to Switch Off Neurons

Karl Deisseroth, M.D. Ph.D, Stanford University
Andre Berndt, Ph.D., Stanford University
Soo Yeun Lee, Ph.D., Stanford University
Charu Ramakrishnan, Stanford University - channels image
Michelle Freund, Ph.D., NIMH

Method of the Year 2010: Optogenetics-NatureVideo  - animation
Optogenetics, Karl Deisseroth, Marina Coral, Nature Methods, 12/20/2010 - graphic

Richard Coppola, Sc.D., NIMH - MEG movie
Cristophe Lenglet, Ph.D., U. Minnesota - brain image

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Introduction to RDoC

Frame from the video Introduction to RDoC.

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Neurobiobank/Jill Bolte Taylor

Frame from the video Neurobiobank/Jill Bolte Taylor.

Jill Bolte Taylor, Ph.D., a spokesperson for the Harvard Brain Tissue Resource Center, discusses why brain donation truly is the gift of hope.

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Dr. Michelle Freund, NIMH Project Officer on the significance of CLARITY

Frame from the video Dr. Michelle Freund, NIMH Project Officer on the significance of CLARITY.

Project officer Michelle Freund, Ph.D., of the NIMH Division of Neuroscience and Basic Behavioral Science, explains the significance of CLARITY, a breakthrough method for analyzing the brain.

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3-D Tour of Intact Mouse Brain

Frame from the video 3-D Tour of Intact Mouse Brain.

CLARITY makes possible this 3D tour of an entire, intact mouse brain. It was imaged using a fluorescence technique that previously could only be performed with thinly-sliced brain tissue, making it difficult to relate micro-level findings to macro-level information about wiring and circuitry. Source: Kwanghun Chung, Ph.D., and Karl Deisseroth, M.D., Ph.D., Stanford University.

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Positive Measures to Fight Depression

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NIMH Radio: Dr. Ron Duman of Yale University talks about ketamine research and treatment for major depression

Ketamine Research and Treatment for Major Depression.

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Stress Hormone Receptors Less Adaptive in Female Brain

Dr. Rita Valentino describes a discovery in rat brains that may explain why women are more prone than men to mood and anxiety disorders.

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Mysteries and Importance of Anesthesia

Frame from the video Mysteries and Importance of Anesthesia.

How the brain reacts to anesthesia is a neuroscientific phenomenon that includes a dash of mystery. But the study of anesthesia could lead to treatment of sleep issues frequently associated with many mental disorders.

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Fear: Replacing Memories

Frame from the video Fear: Replacing Memories.

The human brain goes through a complex process to form and consolidate memories. But is it possible to replace memories of fearful events, and in doing so, assist in the treatment of patients suffering from the debilitating effects of post-traumatic stress disorder or other anxiety disorders? Dr.Joseph LeDoux and a team of New York University neuroscientists think they have found a way to replace traumatic memories through therapy.

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Animal Kingdom: Lessons Learned

Frame from the video Animal Kingdom: Lessons Learned.

The National Institute of Mental Health (NIMH) sat down with researcher Dr. Robert Sapolsky to discuss his ground-breaking research and to answer the question: Can we learn to handle stress by observing animals in the wild? In trying times, the answers may be with the life and death decisions made by these animals and their predators.

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Bees and Socialization

Frame from the video Bees and Socialization.

The National Institute of Mental Health (NIMH) interviewed Dr. Gene Robinson about his recent research on bees and socialization and asks these questions: What is the most altruistic animal? What can we learn from the small, but complex bees?

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Frame from the video Brady-Roadmap.

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Personalized Medicine and Cancer Genomics

Frame from the video Personalized Medicine and Cancer Genomics.

The National Institute of Mental Health (NIMH) talks with Dr. Charis Eng about advances in personalized medicine. As the field of mental health strives to find genetic markers for mental illnesses, we look to the field of cancer research which has made enormous strides in personalized genomic medicine.

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