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Multimedia About Brain Anatomy and Physiology

Frame from the video Channel Makover Switches Off Neurons in a Flash.
Channel Makover Switches Off Neurons in a Flash

Scientists have bioengineered an enhancement to a cutting edge technology that provides instant control over brain circuit activity with a flash of light. The research adds the same level of control over switching neurons off that, until now, had been limited to switching them on. What had been working through a weak pump now works through a highly responsive channel -- like going from a squirt to a gushing hose. Project officer Michelle Freund, Ph.D., of the NIMH Office of Technology Development and Coordination, explains the significance of the new findings.

See: Channel Makeover Bioengineered to Switch Off Neurons

Credits:
Karl Deisseroth, M.D. Ph.D, Stanford University
Andre Berndt, Ph.D., Stanford University
Soo Yeun Lee, Ph.D., Stanford University
Charu Ramakrishnan, Stanford University - channels image
Michelle Freund, Ph.D., NIMH

Method of the Year 2010: Optogenetics-NatureVideo  - animation
Optogenetics, Karl Deisseroth, Marina Coral, Nature Methods, 12/20/2010 - graphic

Richard Coppola, Sc.D., NIMH - MEG movie
Cristophe Lenglet, Ph.D., U. Minnesota - brain image

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Frame from the video 3-D Analysis of Intact Mouse Hippocampus CLARITY.
3-D Analysis of Intact Mouse Hippocampus CLARITY

CLARITY provided this 3D view showing a thick slice of a mouse brain’s memory hub, or hippocampus. It reveals a few different types of cells: projecting neurons (green), connecting interneurons (red), and layers of support cells, or glia (blue). Conventional 2D methods require that brain tissue be thinly sliced, sacrificing the ability to analyze such intact components in relation to each other. CLARITY permits such typing of molecular and cellular components to be performed repeatedly in the same brain. Source: Kwanghun Chung, Ph.D., and Karl Deisseroth, M.D., Ph.D., Stanford University.

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Frame from the video Brain’s Wiring Revealed in HD.
Brain’s Wiring Revealed in HD

New brain wiring images reveal a pervasive 3D grid structure with no diagonals, say scientists funded by the National Institutes of Health.

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Frame from the video Development of the Young Brain.
Development of the Young Brain

For more than twenty years, National Institute of Mental Health neuroscientist Dr. Jay Giedd has studied the development of the adolescent brain. Decades of imaging work have led to remarkable insight and a more than a few surprises.

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