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and treatment of mental illnesses.

Research Highlights about Brain Anatomy and Physiology

line drawing illustration of human brain
Mapping ‘Imbalance’ in Brain Anatomy Across the Lifespan

Researchers in the NIMH Intramural Research Program have developed a new way to measure the degree to which the proportions of an individual person’s brain differ from the proportions typically seen in the broader population. This technique yields new insights into brain development and offers tools for further study.

Image showing immunofluorescence of fear-acquisition tagged neurons in the dentate gyrus during spontaneous recovery. Credit: Springer Nature; Lacagnina et al. 2019
Brain Processes Underlying the Extinction and Reactivation of Fear Memories

In a study published in 2019 in the journal Nature Neuroscience, researchers funded by the National Institute of Mental Health investigated the neurobiological changes that occur in the brain circuits of mice when contextual fear memories — fear of a place where an aversive event occurred — are formed and extinguished.