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Transforming the understanding
and treatment of mental illnesses.

Research Highlights about Depression

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Family-Based Intervention Lowers Long-Term Suicide Risk in Youth

In a recent study supported by the National Institute of Mental Health, researchers examined the impact of a family-based intervention on suicide risk in youth and found risk-reduction benefits up to 10 years later.

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Mindful Mood Balance Effective for Treating Residual Depressive Symptoms and Suicidal Ideation

NIMH-supported researchers have found an online mindfulness-based cognitive behavioral therapy—called Mindful Mood Balance—is effective at reducing residual depressive symptoms and at reducing suicidal ideation in those who experience these symptoms.

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New Approach Allows Magnetic Brain Stimulation to Target Deep Brain Structures

TMS can only directly stimulate the outermost layer of the brain, but NIMH researchers have found that mapping a person’s brain architecture may make it possible to guide TMS to deep brain targets.

Enhanced photo of researchers standing and wearing virtual reality headsets to plan DBS implantation.
Personalizing Deep Brain Stimulation for Treatment-Resistant Depression

A recent NIMH-supported study investigated whether deep brain stimulation could be personalized for individuals with treatment-resistant depression.

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Assessing Suicide Risk Among Childbearing Women in the U.S. Before and After Giving Birth

NIMH-supported researchers investigated suicide risk among women in the year before and year after giving birth.

National Institute of Mental Health
NIMH Addresses Critical Need for Rapid-Acting Interventions for Severe Suicide Risk

NIMH is working to meet the urgent need for rapid-acting suicide prevention interventions by supporting research investigating the feasibility and safety of treatment protocols that have the potential to quickly reduce severe suicide risk in youth and adults.

Using Mobile Technology to Improve Care for Teens with Depression
Using Mobile Technology to Improve Care for Teens with Depression

In a project funded by the NIMH Small Business Technology Transfer program, researchers are investigating whether mobile technology can be used to create a passive monitoring system that can predict teens’ depressive symptoms and improve the quality of their care.

Developing Rapid, Accurate Assessment of Mental Disorders, Suicide Risk in Youth
Developing Rapid, Accurate Assessment of Mental Disorders, Suicide Risk in Youth

For many adults who have a mental disorder, symptoms were present—but often not recognized or addressed—in childhood and adolescence. Early treatment can help prevent more severe, lasting impairment or disability as a child grows up.

Combined Electroconvulsive Therapy and Venlafaxine a Well-Tolerated Depression Treatment for Older Adults
Combined Electroconvulsive Therapy and Venlafaxine a Well-Tolerated Depression Treatment for Older Adults

The use of right unilateral ultrabrief pulse (RUL-UB) electroconvulsive therapy (ECT) in combination with the antidepressant venlafaxine to treat depression in elderly patients is well tolerated and results in minimal neurocognitive side effects, according to a new NIH-funded study published in the American Journal of Geriatric Psychiatry.