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Construct: Initial Responsiveness to Reward Attainment

RDoC Classification

Domain: Positive Valence Systems

Description

Mechanisms/processes associated with hedonic responses—as reflected in subjective experiences, behavioral responses, and/or engagement of the neural systems to a positive reinforcer—and culmination of reward seeking.

Molecules

CREB Endocannabinoids FosB Glutamate Mu and delta opioid Orexin

Circuits

Anterior insula dorsal ACC Lateral hypothalamus Medial OFC Nucleus accumbens Ventral pallidum Ventromedial PFC VTA

Behavior

Taste reactivity

Self-Report

Consummatory subscale of TEPS PANAS (state version)

Paradigms

Simple Guessing Task