Skip to content

Negative Valence Systems: Potential Threat (Anxiety) - NIMH Research Domain Criteria (RDoC)

Domain: Negative Valence Systems
Construct: Potential Threat ("Anxiety")
————— Units of Analysis —————
Genes Molecules Cells Circuits Physiology Behavior Self-Reports Paradigms

CRF

CRF family, cortisol

Pituitary cells

Bed nucleus of stria terminalis

Average cortisol levels, ACTH, potentiated startle

 

 

Contextual threat, darkness (in humans), light (in rodents)