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Transforming the understanding
and treatment of mental illnesses.

Depression Evaluations for Medication and Brain Imaging Studies

Join a Research Study: Enrolling nationally from around the country

To find out if you qualify, email NIMH or call 1-877-646-3644 (1-877-MIND-NIH) [TTY: 711].

This study screens for various inpatient and outpatient studies that investigate the brain and experimental medications (such as ketamine) to quickly lift severe and hard-to-treat depressive symptoms.

Participation may include outpatient visits or inpatient stays lasting 4 to 20 weeks at the NIH Clinical Center, Bethesda, MD. Procedures may include: tapering off current psychiatric medications, a medication-free period, oral or intravenous medication versus placebo, and brain scans. You may also qualify for other studies that have different requirements and lengths of stay.

Participants must be ages 18-70 and free of serious medical conditions. These studies may enroll eligible participants from across the USA. Travel arrangements and compensation are provided. There is no cost to participate.

First steps to participate include, calling NIMH, learning study details, asking about your eligibility, and consenting to participate.

Study Identifiers

  • NIMH Protocol Number: 01-M-0254
  • Study Number: 00024635

Investigator(s): Carlos Zarate Jr, M.D.