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Healthy Volunteers to Assist in finding causes of depression in teenagers

Join a Research Study: Enrolling nationally from around the country

To find out if you qualify, email NIMH or call 1-301-827-1350 [TTY: 1-866-411-1010].

Healthy volunteers (teens who do not have mental health diagnoses) are needed to assist investigators find causes of depression in teenagers. The study goals are to understand how the brain changes when teenagers have depression and use that knowledge to find better treatments for depression. Healthy volunteers who participate in research assist investigators by being members of a group that can be compared to a group of those who have major depression. The study will also follow participants over time as they grow up to compare those with depression to those without.

The study is recruiting both healthy volunteer participants ages 11-17, who do not have a mental health diagnosis, and those who are depressed. All participants must have a pediatrician or other medical provider, be medically healthy, and able to perform research tasks.

Study participation begins with an outpatient evaluation that includes clinical assessment, interviews, and questionnaires.

Outpatient visits for healthy volunteers may include paper-and-pencil and computer tests of mood, memory, and thinking; specialized computer games; and structural and functional brain imaging that does not use harmful radiation. If eligible, study participants may return several times a year, up to age 25.

All clinical evaluations, research tasks and visits are free of cost. Participants are compensated for research activities. Parents and teenager must agree to the teenager’s participation in research.

The studies are conducted at the NIH in Bethesda, Maryland and enroll participants from the local area and from across the United States. Transportation expenses are reimbursed by NIMH.

Study Identifiers

  • NIMH Protocol Number: 18-M-0037
  • Study Number: 03388606
  • Principal Investigator: Argyris Stringaris, M.D., Ph.D., FRCPsych