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Principal Investigator

Biography

Dr. Histed received a Ph.D. from the Massachusetts Institute of Technology, where with Earl K. Miller he studied how frontal and basal ganglia neuronal activity underlies complex behaviors.  He did postdoctoral work at Harvard and the University of Chicago, with R. Clay Reid and John H.R. Maunsell, studying how the cerebral cortex represents the sensory world and developing psychophysical methods to measure perceptual behavior in rodents.  Dr. Histed joined NIMH as an principal investigator in 2016.

Research Interests

A single sensory stimulus or motor action changes the activity of thousands or more neurons in the mammalian cerebral cortex.  Dr. Histed’s group uses sensory behavior in the mouse, combined with in vivo electrophysiology, optogenetics, and two-photon imaging, to understand how the brain interprets the activity of many cells --- how the brain decodes neurons’ spikes to make decisions.

Selected Publications

Goldbach HC, Akitake B, Leedy CE, Histed MH (2021) Performance in even a simple perceptual task depends on mouse secondary visual areas. Elife, in press (e-pub ahead of print) https://doi.org/10.7554/eLife.62156. [Pubmed Link]

Sanzeni A, Akitake B, Goldbach HC, Leedy CE, Brunel N, Histed MH (2020). Inhibition stabilization is a widespread property of cortical networks. Elife 9. https://doi.org/10.7554/eLife.54875. [Pubmed Link]

Sanzeni A, Histed MH (2020). Finding patterns in cortical responses. Elife 9. https://doi.org/10.7554/eLife.56234. [Pubmed Link]

Sanzeni A, Histed MH, Brunel N (2020). Response nonlinearities in networks of spiking neurons. PLoS Comput Biol 16, e1008165. https://doi.org/10.1371/journal.pcbi.1008165. [Pubmed Link]

Histed MH (2018). Feedforward Inhibition Allows Input Summation to Vary in Recurrent Cortical Networks. eNeuro 5. https://doi.org/10.1523/ENEURO.0356-17.2018. [Pubmed Link]


Porter Bldg, Room 3A-1002, MSC 3764
BETHESDA, MD 20814

Phone: +1 301 402 9208

mark.histed@nih.gov