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Human Genetics Branch

Recent Publications

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1. Jiang X, Detera-Wadleigh SD, Akula N, Mallon BS, Hou L, Xiao T, Felsenfeld G, Gu X, McMahon FJ. Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness. Mol Psychiatry. 2018 Aug 22. doi: 10.1038/s41380-018-0207-1. [Epub ahead of print] PubMed PMID: 30135510.

2. Sapp JC, Johnston JJ, Driscoll K, Heidlebaugh AR, Miren Sagardia A, Dogbe DN, Umstead KL, Turbitt E, Alevizos I, Baron J, Bönnemann C, Brooks B, Donkervoort S, Jee YH, Linehan WM, McMahon FJ, Moss J, Mullikin JC, Nielsen D, Pelayo E, Remaley AT, Siegel R, Su H, Zarate C; NISC Comparative Sequencing Program, Manolio TA, Biesecker BB, Biesecker LG. Evaluation of Recipients of Positive and Negative Secondary Findings Evaluations in a Hybrid CLIA-Research Sequencing Pilot. Am J Hum Genet. 2018 Sep 6;103(3):358-366. doi: 10.1016/j.ajhg.2018.07.018. Epub 2018 Aug 16. PubMed PMID: 30122538; PubMed Central PMCID: PMC6128311.

3. Chiu CY, Yuan F, Zhang BS, Yuan A, Li X, Fang HB, Lange K, Weeks DE, Wilson AF, Bailey-Wilson JE, Musolf AM, Stambolian D, Lakhal-Chaieb ML, Cook RJ, McMahon FJ, Amos CI, Xiong M, Fan R. Linear mixed models for association analysis of quantitative traits with next-generation sequencing data. Genet Epidemiol. 2019 Mar;43(2):189-206. doi: 10.1002/gepi.22177. Epub 2018 Dec 9. PubMed PMID: 30537345; PubMed Central PMCID: PMC6375753.

4. McMahon FJ. Population-Based Estimates of Heritability Shed New Light on Clinical Features of Major Depression. Am J Psychiatry. 2018 Nov 1;175(11):1058-1060. doi: 10.1176/appi.ajp.2018.18070789. PubMed PMID: 30380936.

5. Glahn DC, Nimgaonkar VL, Raventós H, Contreras J, McIntosh AM, Thomson PA, Jablensky A, McCarthy NS, Charlesworth JC, Blackburn NB, Peralta JM, Knowles EEM, Mathias SR, Ament SA, McMahon FJ, Gur RC, Bucan M, Curran JE, Almasy L, Gur RE, Blangero J. Rediscovering the value of families for psychiatric genetics research. Mol Psychiatry. 2018 Jun 28. doi: 10.1038/s41380-018-0073-x. [Epub ahead of print] PubMed PMID: 29955165.

6. Wille L, McMahon FJ. Coherence Through Incongruence-Can Genetic Markers Inform Nosology After All? JAMA Psychiatry. 2018 Jan 1;75(1):7-8. doi: 10.1001/jamapsychiatry.2017.3484. PubMed PMID: 29167878.

7. International Consortium on Lithium Genetics (ConLi+Gen), Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Brichant-Petitjean C, Cervantes P, Chen HC, Chillotti C, Cichon S, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Del Zompo M, DePaulo JR, Étain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Tortorella A, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Maj M, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Mitchell PB, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. JAMA Psychiatry. 2017 Nov 9. doi: 10.1001/jamapsychiatry.2017.3433. [Epub ahead of print] PubMed PMID: 29121268.

8. Hou L, Kember RL, Roach JC, O'Connell JR, Craig DW, Bucan M, Scott WK, Pericak-Vance M, Haines JL, Crawford MH, Shuldiner AR, McMahon FJ. A population-specific reference panel empowers genetic studies of Anabaptist populations. Sci Rep. 2017 Jul 20;7(1):6079. doi: 10.1038/s41598-017-05445-3. PubMed PMID: 28729679; PubMed Central PMCID: PMC5519631.

9. Lopes FL, Hou L, Boldt AB, Kassem L, Alves VM, Nardi AE, McMahon FJ. Finding Rare, Disease-Associated Variants in Isolated Groups: Potential Advantages of Mennonite Populations. Hum Biol. 2016 Apr;88(2):109-120. PubMed PMID: 28162000.

10. Gill KE, Cardenas SA, Kassem L, Schulze TG, McMahon FJ. Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disorders. Int J Bipolar Disord. 2016 Dec;4(1):21. Epub 2016 Oct 12. PubMed PMID: 27734417; PubMed Central PMCID: PMC5061680.

11. Cardenas SA, Kassem L, Brotman MA, Leibenluft E, McMahon FJ. Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature. Neurosci Biobehav Rev. 2016 Oct;69:193-215. doi: 10.1016/j.neubiorev.2016.08.002. Epub 2016 Aug 5. Review. PubMed PMID: 27502749; PubMed Central PMCID: PMC5030183.

12. Hou L, Bergen SE, Akula N, Song J, Hultman CM, Landén M, Adli M, Alda M, Ardau R, Arias B, Aubry JM, Backlund L, Badner JA, Barrett TB, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Berrettini WH, Bhattacharjee AK, Biernacka JM, Birner A, Bloss CS, Brichant-Petitjean C, Bui ET, Byerley W, Cervantes P, Chillotti C, Cichon S, Colom F, Coryell W, Craig DW, Cruceanu C, Czerski PM, Davis T, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Edenberg HJ, Étain B, Falkai P, Foroud T, Forstner AJ, Frisén L, Frye MA, Fullerton JM, Gard S, Garnham JS, Gershon ES, Goes FS, Greenwood TA, Grigoroiu-Serbanescu M, Hauser J, Heilbronner U, Heilmann-Heimbach S, Herms S, Hipolito M, Hitturlingappa S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Koller DL, König B, Lackner N, Laje G, Lang M, Lavebratt C, Lawson WB, Leboyer M, Leckband SG, Liu C, Maaser A, Mahon PB, Maier W, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McInnis MG, McKinney R, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Mühleisen TW, Nievergelt CM, Nöthen MM, Novák T, Nurnberger JI Jr, Nwulia EA, Ösby U, Pfennig A, Potash JB, Propping P, Reif A, Reininghaus E, Rice J, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Scheftner WA, Schofield PR, Schork NJ, Schulze TG, Schumacher J, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Smith EN, Squassina A, Stamm T, Stopkova P, Streit F, Strohmaier J, Szelinger S, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt SH, Wright A, Zandi PP, Zhang P, Zollner S, McMahon FJ. Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder. Hum Mol Genet. 2016 Aug 1;25(15):3383-3394. doi: 10.1093/hmg/ddw181. Epub 2016 Jun 21. PubMed PMID: 27329760; PubMed Central PMCID: PMC5179929.