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Laboratory of Cellular and Molecular Regulation

Selected Publications

Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Emery AC, Eiden MV, Mustafa T, Eiden LE. Sci Signal. 2013 Jun 25;6(281):ra51. doi: 10.1126/scisignal.2003993. PMID: 23800469

PACAP controls adrenomedullary catecholamine secretion and expression of catecholamine biosynthetic enzymes at high splanchnic nerve firing rates characteristic of stress transduction in male mice. Stroth N, Kuri BA, Mustafa T, Chan SA, Smith CB, Eiden LE. Endocrinology. 2013 Jan;154(1):330-9. doi: 10.1210/en.2012-1829. Epub 2012 Dec 7. PMID: 23221599

PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress. Lehmann ML, Mustafa T, Eiden AM, Herkenham M, Eiden LE. Psychoneuroendocrinology. 2012 Oct 11. pii: S0306-4530(12)00321-6. doi: 10.1016/j.psyneuen.2012.09.006. [Epub ahead of print] PMID: 23062748.

Signaling through the neuropeptide GPCR PAC₁ induces neuritogenesis via a single linear cAMP- and ERK-dependent pathway using a novel cAMP sensor. Emery AC, Eiden LE. FASEB J. 2012 Aug;26(8):3199-211. doi: 10.1096/fj.11-203042. Epub 2012 Apr 24. PMID: 22532442.

Pituitary adenylate cyclase-activating polypeptide controls stimulus-transcription coupling in the hypothalamic-pituitary-adrenal axis to mediate sustained hormone secretion during stress. Stroth N, Liu Y, Aguilera G, Eiden LE. J Neuroendocrinol. 2011 Oct;23(10):944-55. doi: 10.1111/j.1365-2826.2011.02202.x. PMID: 21824204.

The host range of gammaretroviruses and gammaretroviral vectors includes post-mitotic neural cells. Liu XH, Xu W, Russ J, Eiden LE, Eiden MV. PLoS One. 2011 Mar 28;6(3):e18072. doi: 10.1371/journal.pone.0018072. PMID: 21464894.

PAC1hop receptor activation facilitates catecholamine secretion selectively through 2-APB-sensitive Ca(2+) channels in PC12 cells. Mustafa T, Walsh J, Grimaldi M, Eiden LE. Cell Signal. 2010 Oct;22(10):1420-6. doi: 10.1016/j.cellsig.2010.05.005. Epub 2010 May 12. PMID: 20471475.