CURRICULUM VITAE - Robert B. Innis, MD, PhD

CURRICULUM VITAE  (see PDF version)

NAME:                 Robert B. Innis, MD, PhD
ADDRESS:           Natl. Inst. Mental Health, 10 Center Drive, Bethesda, MD 20892-1026 Phone: 1-301-594-1368
Email: robert.innis@nih.gov
BORN:                  June 6, 1952; Newburgh, New York
EDUCATION:      B.S., Yale College, 1974, Molec. Biophysics & Biochemistry (1970 - 1974) M.D., Johns Hopkins School of Medicine, 1978 (1974 - 1978)
Ph.D., Pharmacology, Johns Hopkins School of Medicine, 1981 (1976 - 1980)
Nuclear Medicine, six-moth training for Authorized User (10 CFR 35) of radiopharmaceuticals in human subjects (1995)
CAREER:
1980-84     Resident in Psychiatry, Yale University (1980 - 1984) 1984-90    Assistant Professor, Dept. Psychiatry, Yale University
1988-01     Director of Psychiatric Research, West Haven VA Medical Center 1989-01       Director of Neurochemical Brain Imaging Program (Dept. Psychiatry) 1990-94                  Associate Professor, Yale Dept. Psychiatry
1994-01     Appointment with tenure, Yale University
1995-96     Associate Professor (secondary), Yale Dept. Pharmacology
1996-01     Professor of Psychiatry (primary) and Pharmacology (secondary), Yale University 1999-01         Scientific Director, Yale/VA PET Center
2001-         Chief, Molecular Imaging Branch, NIMH
2008 -10    Acting Director, Mood and Anxiety Disorders Program, NIMH
LABORATORY WEB SITE: http://intramural.nimh.nih.gov/mib/

PROFESSIONAL HONORS:
1970             Valedictorian of Newburgh Free Academy, a public high school
1974        Phi Beta Kappa, summa cum laude graduate of Yale College
1975-80        Recipient of MD/PhD stipend from the Insurance Medical Scientist Scholarship Training Fund
1983             Winner of Lustman Research Award, Yale Department of Psychiatry
1983           Winner of the Mead Johnson Travel Award to attend American College of Neuropsychopharmacology (ACNP) Meeting in San Juan, Puerto Rico.
1985             Diplomat in psychiatry, certified by the American Board of Psychiatry and Neurology, November, 1985 (certificate #27409).
1986             Winner of Alfred P. Sloan Research Fellowship
1992             Keynote Lecture at Johns Hopkins Conference on PET and SPECT Imaging
1995             Keynote Lecture on Imaging the Dopamine Transporter, meeting organized by Niels Lassen, MD, PhD; Copenhagen, Denmark
1995             Organize Teaching Day on Neuroimaging at American College of Neuropsychopharmacology (ACNP) Meeting in San Juan, Puerto Rico
1996             Keynote Lecture at both Fukui Conference (Fukui, Japan) and Brain Function Imaging Conference (Nagoya, Japan)
1996-            Scientific Advisory Board, Brain & Behavior Research Foundation (formerly NARSAD)
1997-2007    Deputy Editor of Biological Psychiatry
1999             Finalist, Frank Berry Award for US government scientists
1999             Invited Plenary Lecture on neuroreceptor imaging to joint meeting of the Japanese Societies of Nuclear Medicine and Cerebral Blood Flow & Metabolism
2003-2006    Adjunct Professor in the Brain Sciences, Swinburne University, Victoria, Australia

2003             Janssen Distinguished Professor in Psychiatry for the University of Texas Health Science Center at San Antonio, Texas. September 8-10, 2003.
2003             Keynote Lecture, Center of Excellence Symposium on Future of Biomedical Imaging, Tohoku University, Sendai, Japan. November 4-6, 2003.
2005             NIH Director's Merit Award for establishing and directing the joint PhD program in neuroscience with the Karolinska Institutet
2005             Marie Curie Award for best paper at the European Association of Nuclear Medicine meeting in Istanbul, Turkey (October 2005). See publication #207.
2006             Keynote lecture at inauguration of Japan’s Molecular Imaging Program (RIKEN & NIRS), March 13, 2006, Tokyo, Japan.
2007             FDA Visiting Professor Lecture Series, Jan. 11, 2007 on "PET Radioligand Development for CNS and Oncology"
2008             Co-director of proposal to evaluate PET imaging of the peripheral benzodiazepine receptor as a cellular marker of inflammation in Alzheimer’s disease and atherosclerosis. Biomarkers Consortium of NIH, industry, and FDA.
2009             Award for Mentor of the Year, NIMH Intramural Research Program
2010             NIMH Director’s award for “extraordinary commitment to successful scientific writing through effective, dedicated, and inspiring mentoring of NIMH Fellows”
2010             NIMH Director’s award for “outstanding dedication, leadership, and mentorship to the Mood and Anxiety Disorders Program”
2016             Kuhl-Lassen Award from the Society of Nuclear Medicine and Molecular Imaging for a scientist who has made outstanding contributions and whose research in and service to the discipline of functional brain imaging is of the highest caliber
2016             Invited plenary lecture for Japanese Society of Nuclear Medicine
2018             Henry Wagner, Jr., MD, Best Abstract Award at annual meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) for the first successful PET imaging of cyclooxygenase-2 (COX-2) in an animal model of neuroinflammation
2018             Mentor for the Soumen Paul, PhD, who received the SNMMI Young Professionals Committee first place award for his project on PET imaging in transgenic mice, monkeys, and humans of O-GlcNAcase, an enzyme involved in the clearance of hyperphosphorylated tau protein from the brain.
2018             National Center for Advancing Translational Sciences (NCATS) Director’s Award for extraordinary leadership in the discovery and development of first-in-class peripheral CB1 receptor antagonist for therapeutic use in metabolic syndrome.
2019             NIMH award for outstanding efforts to re-establish and enhance the NIMH PET facility while setting or exceeding current regulatory standards

PATENTS
1994             Co-inventor "Iodinated neuroprobe for mapping monoamine reuptake sites." Patents #5,310,912 and 5,439,666
2003             Co-inventor "Neuroprobes for mapping monoamine reuptake sites." Patent #6,537,522
2007             Co-inventor “Radioligands to image amyloid,” submitted.
2008             Co-inventor “Radioligands to image the function of Permeability-glycoprotein (P- gp).” Patent #7,989,630 (8/2/2011).
2014             Co-inventor “Beta-amyloid PET imaging agents.” Patent #8,703,096

INSTITUTIONAL ACTIVITIES:

Yale University
-Chairman, Visiting Lectureship Committee, Department of Psychiatry (1987 - 2001)
-PGY-II Curriculum Evaluation Committee (1988-90)
-Yale Animal Care and Use Committee (1990 - 1993)
-Yale-New Haven Hospital Radiation Safety Committee (1991 - 2001)
-Yale Radioactive Drug Research Committee (1991 - 2001)
-VA Animal Care Committee (1990 - 2001)
-VA Radioactive Drug Research Committee (consultant 1991 - 2001)

National Institutes of Health
-Co-Director, NIH / Karolinska Institute Joint PhD Program in Neuroscience (2001 - )
-NIMH Scientific Director’s Steering Committee (2002 - 2004; 2008 - )
-NIMH IRP Tenure & Promotion Committee (member 2002-2004 and Chair 2004 - 2010)
-NIH Mouse Imaging Facility Steering Committee (2001 - )
-NIH Roadmap Intramural Probe Development Core (2003 - )
-NIMH Technology Advisory Committee (2004 - )
-NIH Radiation Safety Committee (2004 – )

OTHER PROFESSIONAL ACTIVITIES:
-Society for Neuroscience since 1976
-Society of Nuclear Medicine since 1990
-American College of Neuropsychopharmacology, member since 1992
-Society of Biological Psychiatry since 1997
-Society of Nuclear Imaging in Drug Development (SNIDD) 1998 - 2006
-Brain & Behavior Research Foundation (formerly NARSAD), Scientific Advisory Board since 1996

EDITORIAL BOARDS
Synapse; 1992 - 2011
European Journal Nuclear Medicine; 1993 - 2004 Journal of Nuclear Medicine; 1995 - 2003 Psychiatry Research: Neuroimaging, 1996 - 2007
Biological Psychiatry (Deputy Editor) 1997 – 2007; Editorial Board 2008 -

GRANT REVIEW COMMITTEES
NIMH "Clinical Neuroscience and Biological Psychopathology” Member 1995 - 1996. Ad hoc member of several NIH and VA committees

ORIGINAL ARTICLES:

1. R.B. Innis, D.B. Bylund and S.H. Snyder. A simple, sensitive, and specific radioreceptor assay for ß-adrenergic antagonist drugs. Life Sci., 23: 2031-2038, 1978.
2. R.B. Innis and H. Moses. Thallium poisoning. Johns Hopkins Medical Journal, 142: 27-31, 1978.
3. R.B. Innis, F.M.A. Correa, G.R. Uhl, B. Schneider, and S.H. Snyder. Cholecystokinin octapeptide-like immunoreactivity: histochemical localization in rat brain. Proc. Natl. Acad. Sci. USA, 76: 521-525, 1979.
4. F.M.A. Correa, R.B. Innis, G.R. Uhl, and S.H. Snyder. Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain. Proc. Natl. Acad. Sci. USA, 76: 1489-1493, 1979.
5. K.A. Freedberg, R.B. Innis, I. Creese, and S.H. Snyder. Antischizophrenic drugs: differential plasma protein binding and therapeutic activity. Life Sci., 24: 2467-2474, 1979.
6. R.B. Innis, F.M.A. Correa, and S.H. Snyder. Carazolol, an extremely potent ß-adrenergic blocker. Life Sci., 24: 2255-2264, 1979.
7. R.B. Innis, L. Tune, R. Rock, R. DePaulo, D.C. U'Prichard, and S.H. Snyder. Tricyclic antidepressant radioreceptor assay. Eur. J. Pharmacol., 58: 473-477, 1979.
8. F.M.A. Correa, R.B. Innis, B. Rouot, G.W. Pasternak, and S.H. Snyder. Fluorescent probes of alpha- and ß-adrenergic and opiate receptors: biochemical and histochemical evaluation. Neurosci. Lett., 16: 47-53, 1980.
9. S.H. Snyder, R.F. Bruns, J.W. Daly, and R.B. Innis. Multiple neurotransmitter receptors in brain: amines, adenosine and cholecystokinin. Fed. Proceed., 40: 142-146, 1981.
10. R.B. Innis, and S.H. Snyder. Cholecystokinin receptor binding in brain and pancreas: regulation by cyclic and acyclic guanine nucleotides. Eur. J. Pharmacol., 65: 123-124, 1980.
11. R.B. Innis, and S.H. Snyder. Distinct cholecystokinin in receptors in brain and pancreas. Proc. Natl. Acad. Sci. USA, 77: 6917-6921, 1980.
12. F.M.A. Correa, R.B. Innis, L.D. Hester, and S.H. Snyder. Diffuse enkephalinergic innervation from caudate to globus pallidus. Neurosci. Lett., 25: 63-68, 1981.
13. R.B. Innis, D.C. Manning, J.M. Stewart, and S.H. Snyder. 3H-Bradykinin receptor binding in mammalian tissue membranes. Proc. Natl. Acad. Sci. USA, 78: 236-2634, 1981.
14. M.A. Zarbin, J.K. Wamsley, R.B.Innis, and M.J. Kuhar. Cholecystokinin receptors: presence and axonal flow in the rat vagus nerve. Life Sci., 29: 697-705, 1981.
15. M.A. Zarbin, R.B. Innis, J.K. Wamsley, S.H. Snyder, and M.J. Kuhar. Autoradiographic localization of CCK receptors in guinea pig brain. Eur. J. Pharmacol., 71: 349-350, 1981.
16. M.A. Zarbin, R.B. Innis, J.K. Wamsley, S.H. Snyder, and M.J. Kuhar. Autoradiographic localization of cholecystokinin receptors in rodent brain. J. Neurosci., 3: 877-906, 1983.
17. R.B. Innis, R. Andrade, and G.K. Aghajanian. Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra. Brain Res., 335: 381-383, 1985.
18. R.B. Innis, and G.K. Aghajanian. CCK-containing and nociceptive neurons in rat Edinger-Westphal nucleus. Brain Res., 363: 230-238, 1986.
19. R.B. Innis, B.S. Bunney, D.S. Charney, L. Price, W. Glazer, W.G. Sternberg, L. Rubin, and G.R. Heninger. Does the cholecystokinin antagonist proglumide possess antipsychotic activity? Psychiatry Res., 18: 1-7, 1986.
20. R.B. Innis, and G.K. Aghajanian. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain Res., 411: 139-143, 1987.
21. R.B. Innis, D.S. Charney, G.R. Heninger. Differential 3H-imipramine platelet binding in patients with panic disorder and depression. Psychiatry Res., 21: 33-41, 1987.
22. M.F. Kritzer, R.B. Innis, and P.S. Goldman-Rakic. Regional distribution of cholecystokinin receptors in primate cerebral cortex determined by in vitro receptor autoradiography. J. Comp. Neurol., 263: 418-435, 1987.
23. R.B. Innis, and G.K. Aghajanian. Pertussis toxin blocks 5HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. Eur. J. Pharmacol., 143: 195-204, 1987.
24. R.B. Innis, E.J. Nestler, and G.K. Aghajanian. Evidence for G-protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Res., 459: 27-36, 1988.
25. M.F. Kritzer, R.B. Innis, and P.S. Goldman-Rakic. Regional distribution of cholecystokinin receptors in macaque medial temporal lobe determined by in vitro receptor autoradiography. J. Comp. Neurol., 276: 219-230, 1988.
26. D.S. Charney, R.B. Innis, R.S. Duman, S.W. Woods, and G.R. Heninger. Platelet alpha-2 receptor binding and adenylate cyclase activity in panic disorder. Psychopharmacology, 98: 102- 107, 1989.
27. M.S. Lidow, P.S. Goldman-Rakic, P. Rakic, and R.B. Innis. Dopamine D2 receptors in cerebral cortex and striatum of rat and monkey: distribution and pharmacological characterization with [3H]raclopride. Proc. Natl. Acad. Sci. USA, 86: 6412-6416, 1989.
28. A.Y. Deutch, B. Moghaddam, R.B. Innis, J.H. Krystal, G.K. Aghajanian, B.S. Bunney, and D.S. Charney. Mechanisms of action of atypical antipsychotic drugs: implications for novel therapeutic strategies for schizophrenia. Schizophrenia Res., 4: 121-156, 1991.
29. M.F. Kritzer, R.B. Innis, and P.S. Goldman-Rakic. Regional distribution of cholecystokinin binding in macaque basal ganglia determined by in vitro receptor autoradiography. Neuroscience, 38: 81-92, 1990.
30. E.W. Johnson, S.W. Woods, S. Zoghbi, R. Baldwin, and R.B. Innis. Characterization of the benzodiazepine radioligand 125I-Ro16-0154: potential probe for SPECT brain imaging. Life Sci., 47: 1535-1546, 1990.
31. R. Innis, S. Zoghbi, E. Johnson, S. Woods, M. Al-Tikriti, R. Baldwin, J. Seibyl, R. Malison, G. Zubal, D. Charney, G. Heninger, P. Hoffer. SPECT imaging of the benzodiazepine receptor in non-human primate brain with [123I]Ro 16-0154. Eur. J. Pharmacol., 193: 249-252, 1991.
32. R.B. Innis, M.S. Al-Tikriti, S.S. Zoghbi, R.M. Baldwin, E.H. Sybirska, M.A. Laruelle, R.T. Malison, J.P. Seibyl, R.C. Zimmermann, E.W. Johnson, E.O.Smith, D.S. Charney, G.R. Heninger, S.W. Woods, and P.B. Hoffer. SPECT Imaging of the benzodiazepine receptor: feasibility of in vivo potency measurements from stepwise displacements curves. J. Nucl. Med., 32: 1754-1761, 1991.
33. E.W. Johnson, E. Sybirska, M. Al-Tikriti, and R.B. Innis. Calibration of [123I] labeled tissue standards for autoradiographic studies. Applied Radiation and Isotopes, 42: 1199-1201, 1991.
34. J.L. Neumeyer, S. Wang, R.A. Milius, R.M. Baldwin, Y. Zea-Ponce, P.B. Hoffer, E. Sybirska, M. Al-Tikriti, D.S. Charney, R.T. Malison, M.A. Laruelle, and R.B. Innis. [123I]-2-ß-Carbomethoxy- 3-ß-(4-iodophenyl)-tropane (ß-CIT): High Affinity SPECT Radiotracer of Monoamine Reuptake Sites in Brain. J. Med. Chem., 34: 3144-3146, 1991.
35. R.M. Kessler, M.S. Ansari, D.E. Schmidt, T. de Paulis, J.A. Clanton, R. Innis, M. Al-Tikriti, >Manning, D. Gillespie. High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors. Life Sci., 49: 617-628, 1991.
36. M. Al-Tikriti, R. Kessler, R. Roth, and R. Innis. Autoradiographic localization of dopamine D1 and D2 receptors in rat cerebral cortex following unilateral neurotoxic lesions. Brain Res., 575: 39-46, 1992.
37. E.W. Johnson, N.C. de Lanerolle, J.H. Kim, Sundaresan, D.D. Spencer, R. Mattson, S., Zoghbi, R. Baldwin, P. Hoffer, J. Seibyl, and R.B. Innis. "Central" and "peripheral" benzodiazepine receptors: opposite changes in human epileptogenic tissue. Neurology, 42: 811-815, 1992.
38. R.B. Innis, R.T. Malison, M. Al-Tikriti, E.H. Sybirska, S. Zoghbi, R.M. Baldwin, P.B. Hoffer, Roth. Amphetamine-mediated dopamine release competes for [123I]IBZM binding to dopamine D2 receptors in non-human primate brain. Synapse, 10: 177-184, 1992.
39. S.W. Woods, J.P. Seibyl, A.W. Goddard, H.M. Dey, S.S. Zoghbi, M. Germine, R.M. Baldwin, E.O. Smith, D.S. Charney, G.R. Heninger, P.B. Hoffer, and R.B. Innis. Dynamic SPECT imaging of the benzodiazepine receptor in healthy human subjects with [123I]Ro 16-0154. Psychiatry Res. Neuroimaging, 47: 67-77, 1992.
40. E. Sybirska, M. Al-Tikriti, S.S. Zoghbi, R.M. Baldwin, E.W. Johnson, and R.B. Innis. SPECT imaging of the benzodiazepine receptor: autoradiographic comparison of receptor density and radioligand distribution. Synapse., 12: 119-128, 1992.
41. R. Innis, R. Baldwin, E. Sybirska, Y. Zea, M. Laruelle, M. Al-Tikriti, D. Charney, S. Zoghbi, E. Smith, G. Wisniewski, P. Hoffer, S. Wang, R. Milius, and J. Neumeyer. SPECT imaging of monoamine reuptake sites in primate brain with [123I]CIT. Eur. J. Pharmacol., 200: 369-370, 1991.
42. S. Zoghbi, R.M. Baldwin, J.P. Seibyl, M. Al-Tikriti, Y. Zea-Ponce, M. Laruelle, E. Sybirska, S.W. Woods, A. Goddard, R.T. Malison, R. Zimmermann, D. Charney, E.O. Smith, P.B. Hoffer, and R.B. Innis. Pharmacokinetics of the SPECT benzodiazepine receptor radioligand [123I]iomazenil in human and non-human primates. Nucl. Med. Biol., 19: 881-888, 1992.
43. J.P. Seibyl, S.W. Woods, A.W. Goddard, H.M. Dey, S.S. Zoghbi, R.M. Baldwin, I.G. Zubal, M. Germine, E.O. Smith, G.R. Heninger, D.S. Charney, H.F. Kung, A. Alavi, P.B. Hoffer, and R.B. Innis. Dynamic SPECT and whole body imaging of dopamine D2 receptors in human subjects with [123I]IBZM. J. Nucl. Med., 33: 1964-1971, 1992.
44. M. Laruelle, R.M. Baldwin, R.T. Malison, Y. Zea-Ponce, S.S. Zoghbi, M.S. Al-Tikriti, E.H. Sybirska, R.C. Zimmermann, G. Wisniewski, J.L. Neumeyer, R.A. Milius, S. Wang, E.O. Smith, D.S. Charney, R.H. Roth, P.B. Hoffer,and R.B. Innis. SPECT imaging of dopamine and serotonin transporters with [123I]CIT: Pharmacological characterization of brain uptake in nonhuman primates. Synapse, 13: 295-309, 1993.
45. R.M. Baldwin, Y. Zea-Ponce, S.S. Zoghbi, M. Laruelle, M.S. Al-Tikriti, E.H. Sybirska, R.T. Malison, J.L. Neumeyer, R.A. Milius, S. Wang, M.Stabin, E.O. Smith, D.S. Charney, P.B. Hoffer, and R.B. Innis. Evaluation of the monoamine uptake site ligand [123I] methyl 3ß-(4- iodophenyl)tropane-2ß-carboxylate ([123I]ß-CIT) in nonhuman primates: pharmacokinetics, biodistribution, and SPECT brain imaging coregistered with MRI. Nucl. Med. Biol.- Int. J. Rad. App. B. 20: 597-606, 1993.
46. M. Laruelle, A. Abi-Dargham, M.S. Al-Tikriti, Y. Zea-Ponce, S.S. Zoghbi, D.S. Charney, J. Price, J.J. Frost, P.B. Hoffer, R.M. Baldwin, R.B. Innis. SPECT measurement of benzodiazepine receptor number and affinity in primate brain: a constant infusion paradigm with [123I]iomazenil. Eur. J. Pharmacol., 230: 119-123, 1993.
47. S.C. Wall, R.B. Innis, G. Rudnick. Binding of the cocaine analog [125I]-2ß-carbomethoxy-3ß-(4- iodophenyl) tropane (ß-CIT) to serotonin and dopamine transporters: different ionic requirements for substrate and ß-CIT binding. Mol. Pharmacol. 43: 264-270, 1993.
48. R.T. Malison, E.G. Miller, R. Greene, P.B. Hoffer, G. McCarthy, and R.B. Innis. Computer- assisted coregistration of multislice SPECT and MR images by fixed external fiducials. J. Comput. Assist. Tomogr., 17: 952-960, 1993.
49. E.H. Sybirska, J.P. Seibyl, D. Bremner, R.M. Baldwin, M.S. Al-Tikriti, Y. Zea-Ponce, S. Zoghbi, R.T. Malison, C. Bradberry, M. During, A.W. Goddard, S.W. Woods, P.B. Hoffer, D.S. Charney, and R.B. Innis. [123I]Iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain. Neuropharmacol., 32: 671-680, 1993.
50. Y. Zea-Ponce, R.M. Baldwin, S.S. Zoghbi, and R.B. Innis. Formation of [123I]1-iodobutane in labeling [123I]iomazenil by iododestannylation: implications for the reaction mechanism. Appl. Radiat. Isot. 45: 63-68, 1993.
51. S. Wang, Y. Gao, M.A. Laruelle, R.M. Baldwin, B.E. Scanley, R.B. Innis, and J.L. Neumeyer. Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2ß-carbomethoxy-3ß- (4-iodophenyl) tropane (ß-CIT) to monoamine transporters. J. Med. Chem., 36: 1914-1917, 1993.
52. J.D. Bremner, T.M. Scott, R.C. Delaney, S.M. Southwick, J.W. Mason, D.R. Johnson, R.B. Innis, G. McCarthy, D.S. Charney. Deficits in short-term memory in posttraumatic stress disorder. Am. J. Psychiatry, 150: 1015-1019, 1993.
53. P.J. Kontur, M. Al-Tikriti, R.B. Innis, and R.H. Roth. Postmortem stability of monoamines and receptor binding in rat brain. J. Neurochem., 62: 282-290, 1994.
54. M. Laruelle, S.S. Giddings, Y. Zea-Ponce, S.S. Zoghbi, D.S. Charney, J.L. Neumeyer, R.M. Baldwin, and R.B. Innis. In vitro binding of [125I]ß-CIT to dopamine and serotonin transporters under "physiological” conditions. J. Neurochem., 62: 978-986, 1994.
55. R.B. Innis, J.P. Seibyl, E. Scanley, M. Laruelle, A. Abi-Dargham, E. Wallace, R.M. Baldwin, Y. Zea-Ponce, S. Zoghbi, S. Wang, Y. Gao, J.L. Neumeyer, D.S. Charney, P.B. Hoffer, and K. Marek. Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. Proc. Natl. Acad. Sci. USA, 90: 11,965-11,969, 1993.
56. R.M. Baldwin, Y. Zea-Ponce, S.S. Zoghbi, M.S. Al-Tikriti, J.P. Seibyl, E.H. Sybirska, R.T. Malison, M. Laruelle, D.S. Charney, P.B. Hoffer, and R.B. Innis. Pharmacokinetics of three radioiodinated high affinity dopamine D2 receptor ligands ([123I]IBF, Epidepride, and 2’-ISP) in nonhuman primates. Nucl. Med. Biol., 21(7): 969-976, 1994.
57. M. Laruelle, R.M. Baldwin, Z. Rattner, M. Al-Tikriti, Y. Zea-Ponce, S.S. Zoghbi, D.S. Charney, J.C. Price, J.J. Frost, P.B. Hoffer, and R.B. Innis. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates. I. Kinetic analysis of single bolus experiments. J. Cereb. Blood Flow Metab., 14: 439-452, 1994.
58. M. Laruelle, A. Abi-Dargham, M. Al-Tikriti, R.M. Baldwin, Y. Zea-Ponce, S.S. Zoghbi, D.S. Charney, P.B. Hoffer, and R.B. Innis. SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates. II. Equilibrium analysis of constant infusion experiments and correlation with in vitro parameters. J. Cereb. Blood Flow Metab., 14: 453-465, 1994.
59. J.P. Seibyl, E. Wallace, E.O. Smith, R.M. Baldwin, S.S. Zoghbi, Y. Zea-Ponce, Y. Gao, W.Y. Zhang, J.L. Neumeyer, I.G. Zubal, M. Stabin, D.S. Charney, P.B. Hoffer, and R.B. Innis. Whole body biodistribution, radiation absorbed dose, and brain SPECT imaging with [123I]ß-CIT in healthy human subjects. J. Nucl. Med., 35: 764-770, 1994.
60. H.M. Dey, J.P. Seibyl, J.B. Stubbs, S.S. Zoghbi, R.M. Baldwin, E.O. Smith, I.G. Zubal, C. Olson, D.S. Charney, P.B. Hoffer,and R.B. Innis. Human biodistribution and dosimetry of the SPECT benzodiazepine receptor radioligand [123I]iomazenil. J. Nucl. Med., 35: 399-404, 1994.
61. B.E. Scanley, R.M. Baldwin, M.S. Al-Tikriti, M. Laruelle, Y. Zea-Ponce, S. Zoghbi, S.S. Giddings, D.S. Charney, P.B. Hoffer, S. Wang, J.L. Gao, J.L. Neumeyer, and R.B. Innis. Active and inactive enantiomers of ß-CIT: comparison using homogenate binding and SPECT imaging. Mol. Pharmacol., 45: 136-141, 1994.
62. A. Abi-Dargham, M. Laruelle, J. Seibyl, Z. Rattner,R.M. Baldwin, S.S. Zoghbi, Y. Zea-Ponce, D. Bremner, T. Hyde, D.S. Charney, P.B. Hoffer,and R.B. Innis. SPECT measurement of benzodiazepine receptors in human brain with [123I]iomazenil: kinetic and equilibrium paradigms. J. Nucl. Med., 35: 228-238, 1994.
63. M.S. Al-Tikriti, R.M. Baldwin, Y. Zea-Ponce, E. Sybirska, S.S. Zoghbi, M. Laruelle, R.T. Malison, H.F. Kung, R.M. Kessler, I. Nakatsuka, D.S. Charney, P.B. Hoffer, and R.B. Innis. Comparison of three high affinity SPECT radiotracers for the dopamine D2 receptor. Nucl. Med. Biol., 21: 179-188, 1994.
64. M.S. Al-Tikriti, H.M. Dey, S.S. Zoghbi, R.M. Baldwin, Y. Zea-Ponce, and R.B. Innis. Dual isotopic autoradiographic measurement of regional blood flow and benzodiazepine receptor availability following unilateral middle cerebral artery occlusion. Eur. J. Nucl. Med., 21: 196-202, 1994.
65. M.S. Gandelman, R.M. Baldwin, S.S. Zoghbi, Y. Zea-Ponce, and R.B. Innis. Evaluation of ultrafiltration for the free fraction determination of single photon emission computed tomography (SPECT) tracers: ß-CIT, IBF, and iomazenil. J. Pharm. Sci. 83: 1014-1019, 1994.
66. M. Laruelle, E. Wallace, J.P. Seibyl, R.M. Baldwin, Y. Zea-Ponce, S.S. Zoghbi, J.L. Neumeyer, D.S. Charney, P.B. Hoffer, and R.B. Innis. Graphical, kinetic, and equilibrium analyses of in vivo [123I]ß-CIT binding to dopamine transporters in healthy subjects. J. Cereb. Blood Flow Metab., 14: 982-994, 1994.
67. J.D. Elsworth, M. Al-Tikriti, J.R. Sladek, J.R. Taylor, R.B. Innis, D.E. Redmond, and R.H. Roth. Novel radioligands for the dopamine transporter demonstrate the presence of intrastriatal nigral grafts in the MPTP-treated monkey: correlation with improved behavioral function. Exp. Neurol., 126: 300-304, 1994.
68. M. Laruelle, C. van Dyck, A. Abi-Dargham, Y. Zea-Ponce, S.S. Zoghbi, D.S. Charney, R.M. Baldwin, P.B. Hoffer, H.F. Kung, R.B. Innis. Compartmental modeling of [123I]IBF binding to dopamine D2 receptors in healthy subjects. J. Nucl. Med., 35: 743-754, 1994.
69. C.H. van Dyck, J.P. Seibyl, J.B. Stubbs, S.S. Zoghbi, G. Wisniewski, R.M. Baldwin, Y. Zea- Ponce, D.S. Charney, P.B. Hoffer, R.B. Innis. Human biodistribution and dosimetry of the SPECT D2 receptor radioligand [123I]IBF. Nucl Med. Biol., 23: 9-15, 1996.
70. J.L. Neumeyer, S. Wang, Y. Gao, R.A. Milius, N.S. Kula, A. Campbell, R.J. Baldessarini, Y. Zea-Ponce, R.M. Baldwin, R.B. Innis. N-w-fluoroalkyl analogs of (1R)-2ß-carbomethoxy-3ß-(4- iodophenyl)tropane (ß-CIT): radiotracers for PET and SPECT imaging of dopamine transporters. J. Med. Chem., 37: 1558-1561, 1994.
71. A. Abi-Dargham, M. Gandelman, S.S. Zoghbi, M. Laruelle, R.M. Baldwin, P. Randall, Y. Zea- Ponce, D.S. Charney, P.B. Hoffer, R.B. Innis. Reproducibility of SPECT measurement of benzodiazepine receptors in human brain with [123I]iomazenil. J. Nucl. Med., 36: 167-175, 1995.
72. M.S. Al-Tikriti, Y. Zea-Ponce, R.M. Baldwin, S.S. Zoghbi, M. Laruelle, J.P. Seibyl, S.S. Giddings, D.S. Charney, P.B. Hoffer, R. Sparks, J. Stubbs, S. Wang, J.L. Neumeyer, R.B. Innis. Characterization of the dopamine transporter in nonhuman primate brain: homogenate binding, whole body imaging, and ex vivo autoradiography using [125I] and [123I]IPCIT. Nucl. Med. Biol., 22: 649-658, 1995.
73. B.E. Scanley, M.S. Gandelman, M.S. Al-Tikriti, M. Laruelle, Y. Zea-Ponce, R.M. Baldwin, S.S. Zoghbi, P.B. Hoffer, D.S. Charney, J.L. Neumeyer, R.B. Innis. Comparison of [123I]ß-CIT and [123I]IPCIT as single-photon emission tomography radiotracers for the dopamine transporter in nonhuman primates. Eur. J. Nucl. Med., 22: 4-11, 1995.
74. R.M. Baldwin, Y. Zea-Ponce, M.S. Al-Tikriti, S.S. Zoghbi, J.P. Seibyl, S. Wang, R.A. Milius, J.L. Neumeyer, D.S. Charney, P.B. Hoffer, R.B. Innis. Regional brain uptake and pharmacokinetics of [123I]N-ß-fluoroalkyl-3ß-p-iodophenylnortropane-2ß-carboxylic esters in baboons. Nucl. Med. Biol., 22: 214-219, 1995.
75. M. Laruelle, M.S. Al-Tikriti, Y. Zea-Ponce, S.S. Zoghbi, R.M. Baldwin, D.S. Charney, P.B. Hoffer, H.F. Kung, R.B. Innis. In vivo quantification of dopamine D2 receptors in nonhuman primates using [123I]iodobenzofuran. Eur. J. Pharmacol., 263: 39-51, 1994.
76. R.M. Baldwin, A.G. Horti, J.D. Bremner, M.D. Stratton, R.F. Dannals, H.T. Rayvert, Y. Zea- Ponce, H.M. Dey, R. Soufer, D.S. Charney, S.M. Mazza, R.B. Innis. Synthesis and PET imaging of the benzodiazepine receptor tracer [N-methyl-11C]iomazenil. Nucl. Med. Biol., 22: 659-665, 1995.
77. Y. Zea-Ponce, R.M. Baldwin, M. Laruelle, S. Wang, J.L. Neumeyer, R.B. Innis. Simplified multidose preparation of [123I]ß-CIT, a marker for DA transporters. J. Nucl. Med., 36: 525-529, 1995.
78. J.P. Seibyl, Y. Zea-Ponce, L. Brenner, R.M. Baldwin, J.H. Krystal, S. Offord, S. Mochoviak, D.S. Charney, P.B. Hoffer, Innis.R.B. Continuous intravenous infusion of [123I]IBZM for SPECT imaging of human brain dopamine receptors: Occupancy by the novel antipsychotic RWJ-37796. J. Nucl. Med., 37: 11-15, 1996.
79. J.D. Bremner, P. Randall, T.M. Scott, J.P. Seibyl, R.A. Bronen, S.M. Southwick, R.C. Delaney, G. McCarthy, D.S. Charney, and R.B. Innis. MRI-based measurement of hippocampal volume in Posttraumatic Stress Disorder. Am. J. Psychiatry, 152: 973-981, 1995.
80. M. Laruelle, A. Abi-Dargham, C.H. van Dyck, W. Rosenblatt, Y. Zea-Ponce, S.S. Zoghbi, R.M. Baldwin, D.S. Charney, P.B. Hoffer, H. Kung, and R.B. Innis. SPECT imaging of striatal dopamine release after amphetamine challenge in humans. J. Nucl. Med., 36: 1182-1190, 1995.
81. Y. Zea-Ponce, R.M. Baldwin, R.A. Milius, V. Bakthavachalam, and R.B. Innis. [123I]Iodomethane, a main product in the synthesis of 5-[123I]iodo-6-nitroquipazine by iododestannylation. J. Labeled Compd. Radiopharm., 36: 331-337, 1995.
82. J.D. Bremner, R.B. Innis, C.K. Ng, L. Staib, R. Salomon, R.A. Bronen, J. Markey, J. Duncan, J.H. Krystal, D. Rich, G. Zubal, H. Dey, R. Soufer, D.S. Charney. PET measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch. Gen. Psychiatry, 54: 246-256, 1997.
83. C.H. van Dyck, J.P. Seibyl, R.T. Malison, M. Laruelle, E. Wallace, S.S. Zoghbi, Y. Zea-Ponce, R.M. Baldwin, D.S. Charney, P.B. Hoffer, and R.B. Innis. Age-related decline of dopamine transporter binding in human striatum
84. J. Seibyl, M. Laruelle, C. van Dyck, E. Wallace, R.M. Baldwin, S.S. Zoghbi, Y. Zea-Ponce, J.L. Neumeyer, D.S. Charney, P.B. Hoffer, and R.B. Innis. Reproducibility of [123I]ß-CIT SPECT brain measurements of dopamine transporters in healthy human subjects. J. Nucl. Med., 37: 222- 227, 1996.
85. K.L. Marek, J.P. Seibyl, S.S. Zoghbi, Y. Zea-Ponce, R.M. Baldwin, B. Fussell, E.O. Smith, D.S. Charney, P.B. Hoffer, and R.B. Innis. [123I]ß-CIT SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson’s disease. Neurology, 46: 231-237, 1996.
86. R.T. Malison, C.J. McDougle, C.H. van Dyck, L. Scahill, R.M. Baldwin, J.P. Seibyl, L.H. Price, J.F. Leckman, and R.B. Innis. [123I]ß-CIT SPECT imaging demonstrates increased striatal dopamine transporter binding in Tourette’s syndrome. Am. J. Psychiatry, 152: 1359-1361, 1995.
87. J.P. Seibyl, K.L. Marek, D. Quinlan, K. Sheff, S.S. Zoghbi, Y. Zea-Ponce, R.M. Baldwin, B. Fussell, E.O. Smith, D.S. Charney, P.B. Hoffer, and R.B. Innis. Decreased single-photon emission computed tomographic [123I]ß-CIT striatal uptake correlates with symptom severity in idiopathic Parkinson’s disease. Ann. Neurol., 38: 589-598, 1995.
88. A. Abi-Dargham, M.S. Gandelman, G. de Erausquin, Y. Zea-Ponce, S. S. Zoghbi, R. M. Baldwin, M. Laruelle, D.S. Charney, P.B. Hoffer, J.L. Neumeyer, and R.B. Innis. SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of ß-CIT. J. Nucl. Med., 37: 1129-1133, 1996.
89. R.T. Malison, S.E. Best, E.A. Wallace, E. McCance, M. Laruelle, S.S. Zoghbi, R.M. Baldwin, J.S. Seibyl, P.B. Hoffer, L.H. Price, T.R. Kosten, and R.B. Innis. Euphorigenic doses of cocaine reduce [123I]ß-CIT SPECT measures of dopamine transporter availability in human cocaine addicts. Psychopharmacology, 122: 358-362, 1995.
90. J.D. Bremner, R.B. Innis, R.M. Salomon, L. Staib, C.K. Ng, P.L. Delgado, H.L. Miller, R.A. Bronen, J.H. Krystal, J. Duncan, D. Rich, M. Giunti, H. Dey, R. Soufer, and D.S. Charney. Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Arch. Gen. Psychiatry, 54: 364-374, 1997.
91. M. Laruelle, R.N. Iyer, M.S. Al-Tikriti, Y. Zea-Ponce, R. Malison, S.S. Zoghbi, R.M. Baldwin, H.F. Kung, D.S. Charney, P.B. Hoffer, R.B. Innis, C.W. Bradberry. Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates. Synapse, 25: 1- 14, 1997.
92. J.D. Bremner, P. Randall, E. Vermetten, L. Staib, R.A. Bronen, S. Capelli, G. McCarthy, R.B. Innis, D.S. Charney. MRI-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse: A preliminary report. Biol. Psychiatry, 41: 23-32, 1997.
93. J.D. Elsworth, M. Brittan, J.R. Taylor, J.R. Sladek, Jr., M.S. Al-Tikriti, R.B. Innis, D.E. Redmond, Jr., and R.H. Roth. Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated Parkinsonian monkeys. Cell Transplantation, 5: 315-325, 1996.
94. M. Laruelle, A. Abi-Dargham, C.H. van Dyck, R. Gil, C.D. D'Souza, J. Erdos, E. McCance Katz, W. Rosenblatt, S.S. Zoghbi, R.M. Baldwin,. J.P. Seibyl, J. Krystal, D.S. Charney, and R.B. Innis. Single photon computerized tomography of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc. Natl. Acad. Sci. USA, 93: 9235-9240, 1996.
95. A. Abi-Dargham, Y. Zea-Ponce, D. Terriere, M. Al-Tikriti, R.M. Baldwin, P. Hoffer, D. Charney, J.E. Leysen, M. Laruelle, J. Mertens, and R.B. Innis. Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging serotonin 5-HT2A receptors. Eur. J. Pharmacol., 321: 285-293, 1997.
96. M. Laruelle, C. D’Souza, R.M. Baldwin, A. Abi-Dargham, S. Kanes, C.L. Fingado, J.P. Seibyl, M.B. Bowers, D.S. Charney, and R.B. Innis. Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology, 17: 162-174, 1997.
97. Y. Zea-Ponce, R.M. Baldwin, M.D. Stratton, M. Al-Tikriti, R. Soufer, J.M. Schaus, and R.B. Innis. Radiosynthesis and PET imaging of [N-methyl-11C]LY257327 as a tracer for 5-HT transporters. J. Labeled Compd. Radiopharm., 24: 251-254, 1997.
98. B.E. Scanley, R.P. Kennan, S. Cannan, P. Skudlarski, R.B. Innis, and J.C. Gore. Functional magnetic resonance imaging of median nerve stimulation in rats at 2.0 T. Magn. Reson. Med., 37: 969-972, 1997.
99. A. Abi-Dargham, R.B. Innis, G. Wisniewski, R.M. Baldwin, J.L. Neumeyer, and J.P. Seibyl. Human biodistribution and dosimetry of iodine-123-fluoroalkyl analogs of ß-CIT. Eur. J. Nucl. Med., 24: 1422-1425, 1997.
100. J.P. Seibyl, K. Marek, K. Sheff, R.M. Baldwin, S. Zoghbi, Y. Zea-Ponce, D.S. Charney, C.H. van Dyck, P.B. Hoffer, and R.B. Innis. Test/retest reproducibility of [123I]ß-CIT brain measurement of dopamine transporters in Parkinson's patients. J. Nucl Med., 38: 1453-1459, 1997.
101. M. Laruelle, J. Gelernter, and R. Innis. D2 receptor binding potential is not affected by Taq1 polymorphism at the D2 receptor gene, Mol. Psychiatry, 3: 261-265, 1998.
102. R.T. Malison, S.E. Best, C.H. van Dyck, E.F. McCance, E.A. Wallace, M. Laruelle, R.M. Baldwin, J.P. Seibyl, L.H. Price, T.R. Kosten, R.B. Innis. Elevated striatal transporter binding in acutely abstinent cocaine addicts as measured by [123I]ß-CIT SPECT. Am. J. Psychiatry, 155: 832-834, 1998.
103. A. Abi-Dargham, R. Gil, J. Krystal, R.M. Baldwin, J.P. Seibyl, M. Bowers, D.S. Charney, R.B. Innis, and M. Laruelle. Increased striatal dopamine transmission in schizophrenia: results in a second cohort. Am. J. Psychiatry, 155: 761-767, 1998.
104. R.M. Baldwin, P.-Z. Tan, C.H. van Dyck, M. Al-Tikriti, L. Amici, B. Roth, N. Khan, R. Soufer, D.S. Charney and R.B. Innis. Radiometabolites of [18F]altanserin in rats and humans: 4-(p- [18F]fluorobenzoyl)piperidine and [18F]altanserinol. J. Labeled Compd. Radiopharm., 41: 133- 135, 1998.
105. A. Abi-Dargham, J. Krystal, S. Anjivel, E. Scanley, S. Zoghbi, R.M. Baldwin, N. Rajeevan, J. Seibyl, D. Charney, M. Laruelle, and R.B. Innis. Alterations of benzodiazepine receptors in typ II alcoholics measured with SPECT and [123I]iomazenil. Am. J. Psychiatry, 155: 1550-1555, 1998.
106. N. Rajeevan, I.G. Zubal, S.Q. Ramsby, S.S. Zoghbi, J. Seibyl, and R.B. Innis. Significance of nonuniform attenuation correction in quantitative brain SPECT imaging. J. Nucl. Med., 39: 1719- 1726, 1998.
107. J.P. Seibyl, K. Marek, K. Sheff, S. Zoghbi, R.M. Baldwin, D.S. Charney, C.H. van Dyck, and R.B. Innis. Iodine-123-ß-CIT and Iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson’s patients. J. Nucl. Med. 39: 1500-1508, 1998.
108. R.T. Malison, E, McCance, L. Carpenter, R.M. Baldwin, J.P. Seibyl, L.H. Price, T.R. Kosten, and R.B. Innis. [123I]ß-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts. Psychopharmacol., 4: 321-325, 1998.
109. R.T. Malison, L.H. Price, R. Berman, G.H. Pelton, L. Carpenter, G. Sanacora, M. Owens, C.B. Nemeroff, N. Rajeevan, R.M. Baldwin, J.P. Seibyl, R.B. Innis, D.S. Charney. Reduced brain serotonin transporter availability in major depression as measured by [123I]ß-CIT. Biol. Psychiatry, 44: 1090-1098, 1998.
110. S.S. Zoghbi, R.M. Baldwin, J. Seibyl, D.S. Charney, and R.B. Innis. A radiotracer technique for determining apparent pKa of receptor-binding ligands. J. Labeled Compd. Radiopharm., 41: 136- 138, 1998.
111. J.D. Bremner, R.A. Bronen, G. de Erausquin, E. Vermetten, L. Staib, C.K. Ng, D.S. Charney, and R.B. Innis. Anatomically defined regions of interest on PET-MRI coregistration: development, rationale, and reliability of method. Clinical Positron Imaging, 1: 145-159, 1998.
112. J.D. Elsworth, M.S. Brittan, J.R. Taylor, J.R. Sladek, D.E. Redmond, R.B. Innis, Y. Zea-Ponce, and R.H. Roth. Upregulation of striatal D2 receptors in the MPTP-treated vervet monkey is reversed by grafts of fetal ventral mesencephalon: An autoradiographic study. Brain Res., 795: 55-62, 1998.
113. M. Fujita, S.W. Woods, N.P.L.G. Verhoeff, A. Abi-Dargham, R.M. Baldwin, S.S. Zoghbi, J.C. Soares, P.A. Jatlow, J.H. Krystal, N. Rajeevan, D.S. Charney, R.B. Innis. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. Eur. J. Pharmacol., 368: 161-172, 1999.
114. P-Z. Tan, R.M. Baldwin, R. Soufer, C.H. van Dyck, D.S. Charney, and R.B. Innis. Application of the deuterium isotope effect to enhance PET signal by impeding tracer metabolism: synthesis of deuterium and fluorine-18 dual-labeled altanserin and its nitro precursor. J. Labelled Compounds Radiopharm., 40: 130-132, 1997.
115. R.P. Kennan, B. Ellen Scanley, R.B. Innis, and J.C. Gore. Physiological basis for BOLD MR signal changes due to neuronal stimulation: separation of blood volume and magnetic susceptibility effects. Magn. Reson. Med., 40: 840-846; 1998.
116. P.-Z. Tan, R.M. Baldwin, R. Soufer, P.K. Garg, D.S. Charney, and R.B. Innis. A complete remote control system for reliable routine production of [18F]altanserin, radioligand for imaging 5-HT2A receptors in brain with positron emission tomography. J. Applied Radiat. & Isotopes, Appl. Radiat. Isot. 50: 923-927. 1999.
117. M. Fujita, J.P. Seibyl, N.P. Verhoeff, M. Ichise, R.M. Baldwin, S.S. Zoghbi, C. Burger, J.K. Staley, N. Rajeevan, D.S. Charney, and R.B. Innis. Kinetic and equilibrium analyses of [123I]epidepride binding to striatal and extrastriatal dopamine D2 receptors. Synapse., 34: 290-304, 1999.
118. S.S. Zoghbi, G. Tamagnan, M. Fujita, R.M. Baldwin, L. Amici, J. Seibyl, and R.B. Innis. Metabolism of 5-[I-123]-Iodo-3-(2(3)-Azetidinylmethoxy)Pyridine, a nicotinic acetylcholine receptor imaging agent, in non-human primates. J.Labeled Compounds Radiopharm. 42: S666- S668, 1999.
119. C.H. van Dyck, P.-Z. Tan, R.M. Baldwin, L. Amici, P.K. Garg, C.K. Ng, R. Soufer, D.S. Charney, and R.B. Innis. PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin. J. Nucl. Med., 41: 234-241, 2000.
120. N.P.L.G. Verhoeff, O.A.C. Petroff, F. Hyder, S.S. Zoghbi, M. Fujita, N. Rajeevan, J.P. Seibyl, R. Mattson, and R.B. Innis. Effects of vigabatrin on the GABA-ergic system determined by [123I]iomazenil SPECT and GABA MRS. Epilepsia, 40: 1433-1438, 1999.
121. J.D. Bremner, R.B. Innis, T. White, M. Fujita, D. Silbersweig, A. Goddard, L. Staib, E. Stern, A. Cappiello, S. Woods, R. Baldwin, D.S. Charney. SPECT [123I]iomazenil measurement of benzodiazepine receptors in panic disorder. Biol. Psychiatry, 47: 96-106, 2000.
122. A. Abi-Dargham, M. Laruelle, J. Krystal, C. D'Souza, S. Zoghbi, R.M. Baldwin, J. Seibyl, G. de Erausquin, D. Charney, and R.B. Innis. No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia. Neuropsychopharmacol., 20: 650-661, 1999.
123. P-Z. Tan, R.M. Baldwin, D.S. Charney, and R.B. Innis. Rapid synthesis of F-18 and H-2 dual- labeled altanserin, a metabolically resistant PET ligand for 5-HT2A receptors. J. Labeled Compd. Radiopharm., 42: 457-467, 1999.
124. P-Z Tan, RM Baldwin, CH van Dyck, M Al-Tikriti, L Amici, B Roth, N Khan, DS Charney, and RB Innis. Characterization of the radioactive metabolites of the 5-HT2A receptor ligand [18F]altanserin in human, baboon, and rodent. Nucl. Med. Biol., 26: 601-608, 1999.
125. R.B. Innis, K. Marek, K. Sheff, S. Zoghbi, J. Castronuovo, A. Feigin, and J.P. Seibyl. Effect of treatment with L-dopa/carbidopa or L-selegiline on striatal dopamine transporter imaging with [123I]ß-CIT. Mov. Disord., 14:436-442, 1999.
126. J.D. Bremner, R. Baldwin, A. Horti, L.H. Staib, C.K. Ng, P-Z. Tan, Y. Zea-Ponce, S. Zoghbi, J.P. Seibyl, R. Soufer, D.S. Charney, and R.B. Innis. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Res. Neuroimaging, 91: 79-92, 1999.
127. M. Laruelle, A. Abi-Dargham, R. Gil, L. Kegeles, R. Innis. Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol. Psychiatry, 46: 56-72, 1999.
128. M. Ichise, M. Fujita, J.P. Seibyl, N.P. Verhoeff, R.M. Baldwin, S.S. Zoghbi, N. Rajeevan, D.S. Charney, and R.B. Innis. Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D2 receptor binding with [123I]epidepride SPECT. J. Nucl. Med., 40: 1902- 1912, 1999.
129. S.A. Castner, M.S. Al-Tikriti, R.M. Baldwin, J.P. Seibyl, R.B. Innis, and P.S. Goldman-Rakic. Behavioral changes and [123I]IBZM equilibrium SPECT measurement of amphetamine-induced dopamine release in rhesus monkeys exposed to subchronic amphetamine. Neuropsych- opharmacology, 22: 4-13, 2000.
130. M. Laruelle, A. Abi-Dargham, C. van Dyck, R. Gil, C. DeSouza, J. Krystal, J. Seibyl, R. Baldwin, and R. Innis. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]ß-CIT. Biol. Psychiatry, 47: 371-379, 2000.
131. G. Tamagnan, R.M. Baldwin, N.S. Kula, R.J. Baldessarini, and R.B. Innis. Synthesis and monoamine transporter affinity of 2 B-carbomethoxy-3B-(4'-substituted) biphenyltropanes. Bioorganic Med. Chem. Letts. 10: 1783-1785, 2000.
132. J.D. Bremner, R.B. Innis, S.M. Southwick, L. Staib, S. Zoghbi, and D.S. Charney. Decresaed benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic steess disorder. Am. J. Psychiatry, 157: 1120-1126, 2000.
133. A. Varrone, M. Fujita, N.P.L.G. Verhoeff, S.S. Zoghbi, R.M. Baldwin, N. Rajeevan, D.S. Charney, J.P. Seibyl, and R.B. Innis. Test-retest reproducibility of extrastriatal D2 receptor imaging with [123I]epidepride SPECT in humans. J. Nucl. Med., 41: 1343-1351, 2000.
134. N.P.L.G. Verhoeff, J.C. Soares, C.D.D'Souza, R. Gil, K. Degen, A. Abi-Dargham, S.S. Zoghbi, M. Fujita, N. Rajeevan, J.P. Seibyl, J.H. Krystal, C.H. van Dyck, D.S. Charney, and R.B. Innis. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research Neuroimaging, 91: 163-173, 1999.
135. B.E. Scanley, M.S. Gandelman, M. Laruelle, M.S. Al-Tikriti, Y. Zea-Ponce, R.M. Baldwin, S.S. Zoghbi, P.B. Hoffer, D.S. Charney, S. Wang, J.L. Neumeyer, and R.B. Innis. A model based comparison of [123I]IPCIT and [123I]ß-CIT as SPECT tracers for the dopamine transporter in nonhuman primates. Nucl. Med. Biol., 27: 13-21, 2000.
136. M. Fujita, N.P.L.G. Verhoeff, A. Varrone, S.S. Zoghbi, R.M. Baldwin, P.A. Jatlow, G.M. Anderson, J.P. Seibyl, and R.B. Innis. Imaging extrastriatal dopamine D2 receptor occupancy by endogenous dopamine in healthy humans. Eur. J. Pharmacol., 387: 179-188, 2000.
137. M. Fujita, G. Tamagnan, S.S. Zoghbi, R.M. Baldwin, and R.B. Innis. Measurement of a4ß2 nicotinic acetylcholine receptors with [I-123]-5-I-A85380 SPECT. J. Nucl. Med. 41: 1552-1560, 2000.
138. A.G. Mukhin, D. Gündisch, A.G. Horti, A.O. Koren, G. Tamagnan, A.S. Kimes, J. Chambers, D.B. Vaupel, S. King, M.R. Picciotto, R.B. Innis, and E.D. London. 5-Iodo-A-85380, an a4ß2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol. Pharmacol. 57: 642-649, 2000.
139. A. Anand, P. Verhoeff, N. Seneca, S.S. Zoghbi, J.P.Seibyl, D.S. Charney, and R.B. Innis. Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients. Am. J. Psychiatry, 157: 1108-1114, 2000.
140. L.K. Jacobsen, J.K. Staley, R.T. Malison, R.M. Baldwin, J.P. Seibyl, T.R. Kosten, and R.B. Innis. Elevated central serotonin transporter binding in acutely abstinent cocaine dependent patients. Am. J. Psychiatry, 157: 1134-1140, 2000.
141. G. Tamagnan, R. M. Baldwin, N. Kula, R. Baldessarini, and R. B. Innis. Cyclopentadienyl tricarbonylrhenium benzazepine: synthesis and binding affinity. Bioorganic Med. Chem. Letts. 10: 1113-1115, 2000.
142. J. C. Soares, C. van Dyck, P.-Z. Tan, S. S. Zoghbi, P. Garg, R. Soufer, R.M. Baldwin, M. Fujita, J. Staley, X. Fu, L. Amici, J. Seibyl, and R.B. Innis. Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin. Psychiatry Res. Neuroimaging, 106: 81- 93, 2001.
143. J.K. Staley, G. Tamagnan, R.M. Baldwin, M. Fujita, M.S. Al-Tikriti, L. Eshima, J. Thornback, A. Pollak, D. Roe, L. Lu, J.P. Seibyl, and R.B. Innis. SPECT imaging with the D(4) receptor antagonist L-750,667 in nonhuman primate brain. Nucl. Med. Biol., 27: 547-556, 2000.
144. C. H. van Dyck, J. Soares, P.-Z. Tan, J. Staley, R. M. Baldwin, L. A. Amici, X. Fu, P. K. Garg, R. Soufer, J.P. Seibyl, D. S. Charney, and R. B. Innis. Equilibrium modeling of 5-HT2A receptors with [18F]deuteroaltanserin and PET: feasibility of a constant infusion paradigm. Nucl. Med. Biol., 27: 715-722, 2000.
145. L.K. Jacobsen, J.K. Staley, S.S. Zoghbi, J.P. Seibyl, T.R. Kosten, R.B. Innis, and J. Gelernter. Prediction of dopamine transporter binding availability by genotype: a preliminary report. Am. J. Psychiatry. 157: 1700-1703, 2000.
146. C.H. van Dyck, R.T. Malison, J.P. Seibyl, M. Laruelle, S.S. Zoghbi, R.M. Baldwin, and R.B. Innis. Age-related decline in central serotonin transporter availability in human brainstem with [123I] ß -CIT SPECT. Neurobiology Aging. 21: 497-501, 2000.
147. S.S. Zoghbi, G. Tamagnan, M. Fujita, R.M. Baldwin, M. Al-Tikriti, L. Amici, J.P. Seibyl, R.B. Innis. Measurement of plasma metabolites of (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine (5-IA-85380), a nicotinic acetylcholine receptor imaging agent, in nonhuman primates. Nucl. Med. Biol, 28: 91-96, 2001.
148. D. Martinez, J. Gelernter, A. Abi-Dargham, C.H. van Dyck, L. Kegeles, R.B. Innis, and M. Laruelle. The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans. Neuropsychopharmacology. 24: 553-560, 2001.
149. S. Goldstein, J.H. Friedman, R. Innis, J. Seibyl, and K. Marek. Hemi-parkinsonism due to midbrain arteriovenous malformation: dopamine transporter imaging. Mov. Disord. 16: 350-353, 2001.
150. A. Varrone, K.L. Marek, D. Jennings, R.B. Innis, and J.P. Seibyl. [123I]B-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson’s disease and multiple system atrophy. Movement Disorders. 16: 1023-1032, 2001.
151. J.K. Staley, C. van Dyck, P. Tan, M. Al-Tikriti, Q. Ramsby, H. Klump, C. Ng, P. Garg, R. Soufer, R.M. Baldwin, and R.B. Innis. Comparison of [18F]altanserin [18F]deuteroaltanserin for PET imaging of 5-HT2A receptors in baboon brain: pharmacological studies. Nucl. Med. Biol., 28: 271-279, 2001
152. C. van Dyck, D.M. Quinlan, L.M. Cretella, J.K. Staley, R.T. Malison, R.M. Baldwin, JP. Seibyl, R.B. Innis. Striatal dopamine transporter availability with [123I]ß-CIT SPECT is unaltered in adult attention deficit hyperactivity disorder. Am. J. Psychiatry. 159: 309-311, 2002.
153. K. Marek, R. Innis, C. van Dyck, B. Fussell, M. Early, D. Oakes, and J. Seibyl. [123I]ß-CIT SPECT imaging assessment of the rate of Parkinson's disease progression. Neurology. 57: 2089- 2094, 2001.
154. J. K. Staley, S. Krishnan-Sarin, S. Zoghbi, G. Tamagnan, M. Fujita, J.P. Seibyl, P.K. Maciejewski, S. O'Malley, and R.B. Innis. Sex differences in [123I]$-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and non-smokers. Synapse. 41: 275-284, 2001.
155. C.H. van Dyck, J.P. Seibyl, R.T. Malison, M. Laruelle, S.S. Zoghbi, R.M. Baldwin, and R.B. Innis. Age-related decline in dopamine transporters: analysis of striatal subregions, non-linear effects, and hemispheric asymmetries. Am. J. Geriatric Psychiatry. 10: 36-43, 2002.
156. M. Fujita, J.P. Seibyl, D.B. Vaupel, G. Tamagnan, M. Early, S.S. Zoghbi, R.M. Baldwin, A.G. Horti, A.O. Koren, A.G. Mukhin, S. Khan, A. Bozkurt, A.S. Kimes, E.D. London, and R.B. Innis. Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5- I-A-85380 in healthy human subjects. Eur. J. Nucl. Med. 29: 183-190, 2002.
157. Parkinson Study Group, Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA. 287: 1653-1661, 2002.
158. R.T. Malison, C.J. McDougle, C.N. Epperson, H. Klumpp, R.M. Baldwin, J.P. Seibyl, and R.B. Innis. Unchanged serotonin and dopamine transporters in obsessive compulsive disorder measured by [123I]β-CIT SPECT. Psychiatry Res. Neuroimaging. Submitted.
159. L. Ogier, F. Turpin, R.M. Baldwin, F. Riche, H. Law, R.B. Innis, and G. Tamagnan. Rearrangement of a mesylate tropane intermediate in nucleophilic substitution reactions. Synthesis of aza-bicyclo[3.2.1]octane and aza-bicyclo[3.2.2]nonane ethers, imides, and amines. J. Org. Chem., 67: 3637-3642, 2002.
160. P. Emond, J. Vercouillie, R. Innis, S. Chalon, S. Mavel, Y. Frangin, C. Halldin, J.-C. Besnard, D. Guilloteau. Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. J. Med Chem. 45: 1253-1258, 2002.
161. R.R. Cesati, G. Tamagnan, R.M. Baldwin, S.S. Zoghbi, R.B. Innis, N.S. Kula, R.J. Baldessarini, and J.A. Katzenellenbogen. Synthesis of cyclopentadienyltricarbonyl rhenium phenyltropanes by double ligand transfer: organometallic ligands for the dopamine transporter. Bioconjugate Chem. 13: 29-39, 2002.
162. X. Fu, P-Z. Tan, N.S. Kula, R.J. Baldessarini, G. Tamagnan, R.B. Innis, R.M. Baldwin. Synthesis, receptor potency and selectivity of halogenated diphenylpiperidines as serotonin 5- HT2A ligands for PET or SPECT brain imaging. J. Med. Chem. 45: 2319-2324, 2002.
163. M. Ichise, H. Toyama, R.B. Innis, and R.E. Carson. Strategies to improve neuroreceptor parameter estimation by linear regression analysis. J. Cereb. Blood Flow Metab. 22:1271-1281, 2002.
164. K.M. Kim, A. Varrone, H. Watabe, M. Shidahara, M. Fujita, R.B. Innis, H. Iida. Contribution of scatter and attenuation compensation to SPECT images of non-uniformly distributed brain activities. J. Nucl. Med. 44: 512-519, 2003.
165. A. Kugaya, G. Sanacora, N. Verhoeff, M. Fujita, G.F. Mason, N.M. Seneca, A. Bozkurt, S.A. Khan, A. Anand, K. Degen, D.S. Charney, S.S. Zoghbi, R.M. Baldwin, J.P. Seibyl, R.B. Innis. Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT. Biol. Psychiatry. 54:792-799, 2003.
166. A. Kugaya, N.M. Seneca, P.J. Snyder, S.A. Williams, R.T. Malison, R.M. Baldwin, J.P. Seibyl, and R.B. Innis. Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology. 28: 413-420, 2003.
167. M. Fujita, M.S. Al-Tikriti, G. Tamagnan, S.S. Zoghbi, A. Bozkurt, R.M. Baldwin, and R.B. Innis. Influence of acetylcholine levels on the binding of a SPECT nicotinic acetylcholine receptor ligand [123I]5-I-A-85380. Synapse. 48: 25-34, 2003.
168. D.N. Tipre, J.-Q. Lu, M. Fujita, M. Ichise, D.C. Vines, and R.B. Innis. Radiation dosimetry estimates for the PET serotonin transporter probe [11C]DASB determined from whole-body imaging in nonhuman primates. Nucl. Med. Comm. 25: 81-86, 2004.
169. A. Kugaya, G. Sanacora, J.K. Staley, R.T. Malison, A. Bozkurt, S. Khan, A. Anand, R.M. Baldwin, J.P. Seibyl, D. Charney, R.B. Innis. Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors. Biol. Psychiatry. 56: 497-502, 2004.
170. A. Kugaya, C.N. Epperson, S. Zoghbi, C.H. van Dyck, Y. Hou, M. Fujita, J.K. Staley, P.K. Garg, J.P. Seibyl, R.B. Innis. Estrogen increases serotonin2A receptors in the prefrontal cortex in postmenopausal women. Am. J. Psychiatry. 160: 1522-24, 2003.
171. M. Schou, C. Halldin, J. Sovago, V.W. Pike, B. Gulyas, P.D. Mozley, D.P. Johnson, H. Hall, R.B. Innis, and L. Farde. Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand [11C]MeNER. Nucl. Med. Biol. 30: 707-714, 2003.
172. D.C. Vines, M. Ichise, J.-S. Liow, H. Toyama, and R.B. Innis. Evaluation of two scatter correction methods using a striatal phantom for quantitative brain SPECT. J. Nucl. Med Technology. 31: 157-160, 2003.
173. M. Ichise, J-S. Liow, J-Q Lu, A. Takano, K. Modell, H. Toyama, T. Suhara, K. Suzuki, R.B. Innis, and R.E. Carson. Linearized reference tissue parametric imaging methods: application to [11C]DASB PET studies of serotonin transporter in human brain. J. Cereb. Blood Flow Metab. 23: 1096-1112, 2003.
174. Q. Li, R.B. Innis, H. Huang, M. Laruelle, and D.L. Murphy. Pharmacologic and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethy- lphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl- phenylthio)]benzonitrile (DASB). J. Pharmacol. Exp. Therap. 3-8: 481-486, 2004.
175. C.H. van Dyck, R.T. Malison, J.K. Staley, L.K. Jacobsen, J.P. Seibyl, M. Laruelle, R.M. Baldwin, R.B. Innis, and J. Gelernter. Central serotonin transporter availability with [123I]β-CIT SPECT in relation to serotonin transporter genotype. Am. J. Psychiatry. 161: 525-531, 2004.
176. H. Toyama, M. Ichise, J.-S. Liow, D.C. Vines, N.M. Seneca, K.J. Modell, J. Seidel, M.V. Green, and R.B. Innis. Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET. Nucl. Med. Biol. 31: 251-256, 2004.
177. M. Fujita, M. Ichise, C.H. Van Dyck, S.S. Zoghbi, G. Tamagnan, A.G. Mukhin, A. Bozkurt, N. Seneca, D. Tipre, C.C. DeNucci, H. Iida, D.B. Vaupel, A.G. Horti, A.O. Koren, A.S. Kimes, E.D. London, J.P. Seibyl, R.M. Baldwin, and R.B. Innis. Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET. Eur. J. Nucl. Med. Mol. Imaging. 30: 1620-29, 2003.
178. A. Abi-Dargham, L. Kegeles, D. Martinez, R.B. Innis, and M. Laruelle Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naive healthy volunteers: results from a large cohort. Eur. Neuropsychopharmacology. 13: 459-468, 2003.
179. R.M. Baldwin, X. Fu, N.S. Kula, R.J. Baldessarini, L. Amici, R.B. Innis, and G.D. Tamagnan. Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM. Bioorganic Med. Chem. Lett. 13: 4015-4017, 2003.
180. L. Cai, F.T. Chin, V.W. Pike, H. Toyama, J-S. Liow, S.S. Zoghbi, K. Modell, E. Briard, H.U. Shetty, K. Sinclair, S. Donohue, D. Tipre, M-P. Kung, C. Dagostin, D.A. Widdowson, M. Green, W. Gao, M.M. Herman, M. Ichise, and R.B. Innis. Synthesis and evaluation of two 18F-labeled 6-iodo-2-(41-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for β-amyloid in Alzheimer’s disease. J. Med. Chem. 47: 2208-2218, 2004.
181. N. Tipre, M. Fujita, F.T. Chin, Nn Seneca, D. Vines, J-S. Liow, V.W.Pike, and R.B. Innis. Whole-body biodistribution and radiation dosimetry estimates for the PETdopamine transporter probe, [18F]FECNT, in non-human primates. Nucl. Med Comm. 25: 737-742, 2004.
182. H. Toyama; M. Ichise; J.S. Liow; K.J. Modell; D.C. Vines; T. Esaki; M. Cook; J. Seidel; L. Sokoloff; M.V. Green; and R.B. Innis. Absolute quantification of regional cerebral glucose utilization in mice by [18F]FDG/small animal PET scanning and 2-[14C]DG autoradiography. J. Nucl. Med. 45: 1398-1405, 2004.
183. F. Bois, R.M. Baldwin, N.S. Kula, R.J. Baldessarini, R.B. Innis, and G. Tamagnan. Synthesis and monoamine transporter affinity of 3'-analogs of 2β-carbomethoxy-3β-(4'-iodophenyl)tropane (β- CIT). Bioorganic Med. Chem. Lett. 14: 2117-2120, 2004.
184. J-Q. Lu, M. Ichise, J-S. Liow, S. Ghose, D. Vines, R.B. Innis. Biodistribution and radiation dosimetry of the serotonin transporter ligand [11C]DASB determined from human whole body PET. J. Nucl. Med. 45: 1555-1559, 2004.
185. M. Fujita, S.M. Southwick, C. DeNucci, S.S. Zoghbi, M.S. Dillon, R.M. Baldwin, A. Bozkurt, A. Kugaya, N.P.L.G. Verhoeff, J.P. Seibyl, and R.B. Innis. Central type benzodiazepine receptors in Gulf War veterans with post-traumatic stress disorder. Biol. Psychiatry. 56: 95-100, 2004.
186. M. Fujita, A. Varrone, K.M. Kim, H. Watabe, S.S. Zoghbi, N. Seneca, D. Tipre, J.P. Seibyl, R.B. Innis, and H. Iida. Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride SPET. Eur. J. Nucl. Med. Mol. Imaging. 31: 644-654, 2004.
187. M. Schou, C. Halldin, J. Sovago, V.W. Pike, H. Hall, B. Gulyas, P.D. Mozley, D. Dobson, E. Shchukin, R.B. Innis, and L. Farde. PET evaluation of novel radiofluorinated reboxitine analogs as norepinephrine transporter probes in the monkey brain. Synapse. 53: 57-67, 2004.
188. S.J. Finnema, N. Seneca, L. Farde, E. Shchukin, J. Sovago, B. Gulyas, H.A. Wikström,, R.B. Innis, J.L. Neumeyer, and C. Halldin. A preliminary PET evaluation of a new dopamine D2 receptor agonist [11C]MNPA in the cynomolgus monkey. Nucl. Med. Biol. 32: 353-360, 2005.
189. M. Fujita, S.S. Zoghbi, M.S. Crescenzo, J. Hong, J.L. Musachio, J.Q. Lu, J.-S. Liow, N.Seneca, D.N. Tipre, V.L. Cropley, M. Imaizumi, A.D. Gee, J. Seidel, M.V. Green, V.W. Pike, and R.B. Innis. Quantification of brain phosphodiesterase 4 in rat with (R)-[11C]rolipram-PET. NeuroImage. 26: 1201-1210, 2005.
190. M. Schou, C. Halldin, V.W. Pike, P.D. Mozley, D. Dobxon, R.B. Innis, L. Farde, H. Hall. Post- mortem human brain autoradiography of the norepinephrine transporter using (S,S)- [18F]FMeNER-D2. Eur.J. Neuropsychopharmacology. 15: 517-520, 2005.
191. N. Seneca, B. Andree, N. Sjoholm, M. Schou, S. Pauli, P.D. Mozley, J.B. Stubbs, J-S. Liow, J. Sovago, B. Gulyas, R. Innis, and C. Halldin. Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non human primates. Nucl. Med. Comm. 26: 695-700, 2005.
192. G. Tamagnan, D. Alagille, X. Fu, N.S. Kula, R.J. Baldessarini, R.B. Innis, and R.M. Baldwin. Synthesis and monoamine transporter affinity of new 2ß-carbomethoxy-3ß-[4-(substituted thiophenyl)]phenyltropanes: discovery of selective SERT antagonist with picomolar potency. Bioorg. Med. Chem. Lett, 15: 1131-1133, 2005
193. J.K. Staley, C. Gottschalk, I. L. Petrakis, R. Gueorguieva, S. O’Malley, R. Baldwin, P. Jatlow, N.P.L.G. Verhoeff, E. Perry, D. Weinzimmer, E. Frohlich, E. Ruff, C.H. van Dyck, J.P. Seibyl,
     R.B. Innis, and J.H. Krystal. Cortical (-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking. Arch. Gen. Psychiatry. 62: 877-888, 2005.
194. C.H. van Dyck, R.T. Malison, L.K. Jacobsen, J.P. Seibyl, J.K. Staley, M. Laruelle, R.M. Baldwin, R. B. Innis, J. Gelernter. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. J. Nucl. Med. 46: 745-751, 2005.
195. S. Ghose, M. Fujita, P. Morrison, George Uhl, Dennis L. Murphy, P.D. Mozley, C. Halldin, and R. Innis. Specific in vitro binding of (S,S)-[3H]MeNER to norepinephrine transporters. Synapse. 56: 100-104, 2005.
196. H. Toyama, D. Ye, M. Ichise, J-S. Liow, L. Cai, D. Jacobowitz, J.L. Musachio, J. Hong, M. Crescenzo, D. Tipre, J.-Q. Lu, Sami Zoghbi, D.C. Vines, J. Seidel, K. Katada, M.V. Green, V.W. Pike, R.M. Cohen, and R.B. Innis. PET imaging of brain with the beta-amyloid probe, [11C]6- OH-BTA-1, in a transgenic mouse model of Alzheimer’s disease. Eur. J. Nucl. Med. Mol. Imaging. 32: 593-600, 2005.
197. J.K. Staley, G. Sanacora, G. Tamagnan, P.K. Maciejewski, R.T. Malison, R.M. Berman, M. Vythilingam, A. Kugaya, R.M. Baldwin, J.P. Seibyl, D. Charney and R.B. Innis. Sex differences in diencephalon serotonin transporter availability in major depression. Biol. Psychiatry. 59: 40- 47, 2006.
198. G. Tamagnan, D. Alagille, X. Fu, N.S. Kula, R.J. Baldessarini, R.B. Innis, and R.M. Baldwin. Synthesis and monoamine transporter affinity of new 2ß-carbomethoxy-3ß-[aryl or heteroaryl]phenyltropanes. Bioorg. Med. Chem. Lett. 16: 217-220, 2006.
199. R.M. Baldwin, S.S. Zoghbi, J.K. Staley, E. Brenner,, M.S. Al-Tikriti, L. Amici, M. Fujita, R.B. Innis, G. Tamagnan. Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 (5-IA) in baboon brain and plasma. Nucl. Med. Biol. 33: 549-554, 2006.
200. S.E. Best, P.M. Sarrel, R.T. Malison, M. Laruelle, R.M. Baldwin, J.P. Seibyl, R.B. Innis, C.H. van Dyck. Striatal dopamine transporter availability with [123I]ß-CIT SPECT is unrelated to gender or menstrual cycle. Psychopharmacology. 183: 181-189, 2005.
201. S. Li, Z. Chen, Y. Zhang, M. Lizak, J. Bacher, R.B. Innis, J. Shen. In vivo single-shot, proton- localized 13C MRS of rhesus monkey brain. NMR in Biomedicine. 18: 560-569, 2005.
202. M. Fujita, M. Ichise, S.S. Zoghbi, J.-S. Liow, S. Ghose, D.C. Vines, J. Sangare, J.Q. Lu, V.L. Cropley, H. Iida, K.M. Kim,, R.M. Cohen, W. Bara-Jimenez, B. Ravina, and R.B. Innis. Widespread decrease of nicotinic acetylcholine receptors in Parkinson’s disease. Ann.Neurol. 59: 174-177, 2006.
203. J.S. Kim, M. Ichise, and R.B. Innis. PET imaging of serotonin transporters with [11C]DASB: test- retest reproducibility using a multilinear reference tissue parametric imaging method. J. Nucl. Med. 47: 208-214, 2006.
204. D.N. Tipre, S.S. Zoghbi, J.-S. Liow, M.V. Green, J. Seidel, M. Ichise, R.B. Innis, and V.W. Pike. PET imaging of brain 5-HT1A receptors in rat in vivo with [18F]FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole. J. Nucl. Med. 47: 345-353, 2006.
205. V.L Cropley, M. Fujita, J.L. Musachio, J. Hong, S. Ghose, J. Sangare, P.J. Nathan, V.W. Pike; and R.B Innis. Whole-body biodistribution and estimation of radiation-absorbed doses of the dopamine D1 receptor radioligand 11C-NNC 112 in humans. J. Nucl. Med. 47: 100-104, 2006.
206. S.S. Zoghbi, H.U. Shetty, M. Ichise, M. Fujita, M. Imaizumi, J.-S. Liow, J. Shah, J.L. Musachio, V.W. Pike, R.B. Innis. PET imaging of the dopamine transporter with 18F-2β-carbomethoxy-(4- chlorophenyl)-8-(2-fluoroethyl)nortropane (FECNT): A polar radiolabeled metabolite confounds brain radioligand measurements. J. Nucl. Med. 47: 520-527, 2006.
207. N. Seneca, S.J. Finnema, B. Gulyas, H.V. Wikstrom, L. Farde, C. Halldin, and R.B. Innis. Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: A comparison of the agonist ligand [11C]MNPA and the antagonist radioligand [11C]raclopride. Synapse. 59: 260- 269, 2006.
208. J. Vercouillie, S. Mavel, L. Galineau, T. Ragusa, R. Innis, M. Kassiou, S. Chalon, F. Dolle, J.C. Besnard, D. Guilloteau, and P. Emond. Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin tyransportyer ligands. Bioorganic Med. Chem. Letts. 16: 1297-1300, 2006.
209. J.L. Musachio, J. Hong, M. Ichise, N. Seneca, A.K. Brown, J.-S. Liow, S.S. Zoghbi, C. Halldin,R.B. Innis, V.W. Pike, R. He, J. Zhou, A.P. Kozikowski. Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors. Bioorganic & Med. Chem. Letts. 16:3101-3104, 2006.
210. M. Ichise, D.C. Vines, T. Gura, G.M. Anderson, S.J. Suomi, J.D. Higley, R.B. Innis. Effects of early life stress on [11C]DASB PET imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. J. Neurosci. 26: 4638-4643, 2006.
211. N. Seneca, B. Gulyás, A. Varrone, M. Schou, J. Tauscher, F. Vandenhende, W. Kielbasa, L. Farde, R.B Innis, and C. Halldin. Atomoxetine occupies the norepinephrine transporter in a dose- dependent fashion: A PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2. Psychopharmacology. 188: 119-127, 2006.
212. H.U. Shetty, S.S. Zoghbi, J.-S. Liow, M. Ichise, J.S. Hong, J.L. Musachio, N. Seneca, C. Halldin, J. Seidel, R.B. Innis, and V.W. Pike. Identification and regional distribution in rat brain of radiometabolites of the dopamine transporter PET radioligand [11C]PE2I. Eur. J. Nucl. Med.& Mol. Imaging. 34: 667-678, 2007.
213. F. Bois, R.M. Baldwin, N.S. Kula, R.J. Baldessarini, M. Al-Tikriti, R.B. Innis, and G. Tamagnan. Synthesis and monoamine transporter affinity of 2β-(carbomethoxy)-3β-(4’-p-substituted phenyl)-piperidine-based analogs of cocaine. Bioorg. Med. Chem. Lett. 16: 5222-5225, 2006.
214. F. Yasuno, S.S. Zoghbi, J.A. McCarron, J. Hong, M. Ichise, A.K. Brown, R.L. Gladding, J.D. Bacher, V.W. Pike, and R.B. Innis. Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)RWAY. Synapse. 60: 510-520, 2006.
215. A.K. Brown, D.T. George, M. Fujita, J.-S. Liow, M. Ichise, J. Hibbeln, S. Ghose, J. Sangare, D. Hommer, and R.B. Innis. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcoholism: Clin. & Exp. Res. 31: 1-5, 2007.
216. J-S. Liow, S. Lu, J.A. McCarron, J. Hong, J.L. Musachio, V.W. Pike, R.B. Innis, and S.S. Zoghbi. Effect of a P-glycoprotein inhibitor, Cyclosporine A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand [11C](R)-(-)RWAY. Synapse. 61: 96-105, 2007.
217. M. Imaizumi, H.-J. Kim, S.S. Zoghbi, E. Briard, J. Hong, J.L. Musachio, C. Ruetzler, D.-M. Chuang, V.W. Pike, R.B. Innis, and M. Fujita. PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat. Neurosci. Lett. 411, 200-205, 2007.
218. M. Fujita, M. Imaizumi, C. D'Sa, S.S. Zoghbi, M.S. Crescenzo, J. Hong, J.L. Musachio, A.D. Gee, J. Seidel, M.V. Green, V.W. Pike, R.S. Duman, and R.B. Innis. In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant treatment, Synapse. 61: 78- 86, 2007.
219. D.R. Sprague, F.T. Chin, J.-S. Liow, M. Fujita, H.D. Burns, R. Hargreaves, J.B. Stubbs, V.W. Pike, R.B. Innis, and P.D. Mozley. Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: Comparison of thin-slice, bisected, and 2- dimensional planar image analysis. J. Nucl. Med. 48: 100-107, 2007.
220. F. Yasuno., S.M. Sanabria, H.D. Burns, R.J. Hargreaves, S. Ghose, F.T. Chin, C.L. Morse, J. Hong, V.W. Pike, and R.B. Innis. PET imaging of neurokinin-1 (NK1) receptors with [18F]SPA- RQ in human subjects: Assessment of reference tissue models and their test-retest reproducibility. Synapse. 61: 242-251, 2007.
221. X.-Y. Zhang, F. Yasuno, J.A. McCarron, S.S. Zoghbi, J.-S. Liow, J. Hong, J.A. McCarron, V.W. Pike, and R.B. Innis. Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(−)- RWAY: Radiometabolite(s) likely confound brain measurements. Synapse. 61: 469-477, 2007.
222. M. Imaizumi, E. Briard, S.S. Zoghbi, J.P. Gourley, J. Hong, J.L. Musachio, R. Gladding, V.W. Pike, R.B. Innis, and M. Fujita. Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain. Synapse. 61: 595-605, 2007.
223. J.A. Rodriguez-Gomez*, J.-Q. Lu*, I. Velasco, S. Rivera, S.S. Zoghbi, J-S. Liow, J.L. Musachio, F.T. Chin, H. Toyama, J. Seidel, M.V. Green, P.K. Thanos, M. Ichise, V.W. Pike, R.B. Innis* and R.D.G. McKay*. Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease. Stem Cells. 25: 918-928, 2007. (*contributed equally as first or last authors).
224. J.A. McCarron, S.S. Zoghbi, H. U. Shetty, J. Hong, E.S. Vermeulen, H.V. Wikström, M. Ichise, F. Yasuno, C. Halldin, R.B. Innis, and V.W. Pike. Synthesis and initial evaluation of [11C](R)- RWAY in monkey – A new, simply-labeled radioligand for imaging brain 5-HT1A receptors with PET. Eur. J. Nucl. Med Mol. Bio. 34: 1670-1682, 2007.
225. C.H. van Dyck, R.A. Avery, M.G. MacAvoy, K.L. Marek, D.M. Quinlan, R.M. Baldwin, J.P. Seibyl, R.B. Innis, A.F.T. Arnsten. Striatal dopamine transporters correlate with simple reaction time in elderly subjects. Neurobiology of Aging. 29: 1237-1246, 2008.
226. R.B. Innis, V.J. Cunningham, J. Delforge, et al. with a total of 30 authors. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J. Cereb. Blood Flow Metab. 27: 1533-1539, 2007.
227. F. Yasuno, A.K. Brown, S.S. Zoghbi, J.H. Krushinski, E. Chernet, J. Tauscher, J. Schaus, L. Phebus, R.L. A.K. Chesterfield, C. Felder, Gladding, J. Hong, C. Halldin, V.W. Pike, and R.B. Innis. The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain. Neuropsychopharmacology, 33: 259-269, 2008.
228. Y.H. Ryu, J.-S. Liow, S.S. Zoghbi, M. Fujita, J. Collins, D. Tipre, J. Sangare, J. Hong, V.W. Pike, and R.B. Innis. Disulfiram inhibits defluorination of [18F]FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to 5-HT1A receptors in brain. J. Nucl. Med. 48: 1154 – 1161, 2007.
229. L. Cai, J. Cuevas, S. Temme, M.M. Herman, C. Dagostin, D.A. Widdowson, R.B. Innis, and V.W. Pike. Synthesis and structure-affinity relationships of new 4-(6-Iodo-H-imidazo[1,2- a]pyridine-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human β-amyloid plaques. J. Med. Chem. 50: 4746-4758, 2007.
230. F.G. Siméon, A.K. Brown, S.S. Zoghbi, V.M. Patterson, R.B. Innis, and V.W. Pike. Synthesis and simple 18F-labeling of a high affinity 2-(fluoromethyl)thiazole derivative ([18F]SP203) as a radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with PET. J. Med. Chem. 50: 3256-3266, 2007.
231. N. Seneca, L. Cai, J.-S. Liow, S.S. Zoghbi, R.L. Gladding J.Hong, V.W. Pike, and R.B. Innis. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for β-amyloid. Nucl. Med. Biol. 34: 681–689, 2007.
232. M. Imaizumi, E. Briard, S.S. Zoghbi, J.P. Gourley, J. Hong, Y. Fujimura, V.W. Pike, R,B. Innis, and M. Fujita. Brain and whole-body imaging in nonhuman primates of [11C]PBR-28, a promising PET radioligand for peripheral benzodiazepine receptors. NeuroImage. 39: 1289-1298, 2008.
233. E. Briard, S.S. Zoghbi, M. Imaizumi, J.P. Gourley, H.U. Shetty, J. Hong, V. Cropley, M. Fujita, R.B. Innis, and V.W. Pike. Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J. Med. Chem. 51: 17-30, 2008.
234. A.K. Brown, M. Fujita, Y. Fujimura, J.-S. Liow, M. Stabin, Y.H. Ryu, M. Imaizumi, J. Hong, V.W. Pike, and R.B. Innis. Radiation dosimetry and biodistribution in monkey and man of 11C- PBR28, a PET radioligand to image inflammation. J. Nucl. Med. 48: 2072-2079, 2007.
235. L. Cai, J-S. Liow, S.S. Zoghbi, J. Cuevas, C. Baetas, J. Hong, H.U. Shetty, N.M. Seneca, A.K. Brown, R. Gladding, S.S. Temme, M.M. Herman, R.B. Innis, and V.W. Pike. Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N- dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging ß-amyloid plaques in Alzheimer's disease. J. Med. Chem. 51: 148-158, 2008.
236. M. Fujita, M. Imaizumi, S.S. Zoghbi, Y. Fujimura, A.G. Farris, T. Suhara, J. Hong, V.W. Pike, and R.B. Innis. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation. NeuroImage. 40: 43-52, 2008.
237. S.S. Zoghbi, J.-S. Liow, F. Yasuno, J. Hong, E. Tuan, N. Lazarova, R.L. Gladding, V.W. Pike, and R.B. Innis. 11C-Loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux. J. Nucl. Med. 49: 649-656, 2008.
238. V.L. Cropley, M. Fujita, W. Bara-Jimenez, A.K. Brown, X.-Y. Zhang, J. Sangare, P. Herscovitch, V.W. Pike, M. Hallett, P.J. Nathan, and R.B. Innis. Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive function in Parkinson disease: PET studies with [11C]NNC 112 and [18F]FDOPA. Psychiatry Res. Neuroimaging. 163: 171-182, 2008.
239. G. Terry, J.-S. Liow, E. Chernet, S.S. Zoghbi, L. Phebus, C.C. Felder, J. Tauscher, J.M. Schaus, V.W. Pike, C. Halldin, and R.B. Innis. Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents. NeuroImage. 41: 690-698, 2008.
240. V.L. Cropley; R.B. Innis, P.J. Nathan, A.K. Brown, J.L. Sangare, A. Lerner, Y.H. Ryu, K.E. Sprague, V.W. Pike, and M. Fujita. Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans. Synapse. 62: 399-408, 2008.
241. F. Bois, R.M. Baldwin, L. Amici, M.S. Al-Tikriti, N. Kula, R. Baldessarini, R.B. Innis, J.K. Staley, and G.D. Tamagnan. Synthesis, radiolabeling and baboon SPECT imaging of 2$- carbomethoxy-3$-(3’-[123I]iodophenyl)tropane ([123I]YP256) as a serotonin transporter radiotracer. Nucl. Med. Biol. 35: 53-59, 2008.
242. D.R. Sprague, M. Fujita, Y.H. Ryu, J.-S. Liow, V.W. Pike, and R.B. Innis. Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [11C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrasected image analyses. Nucl. Med. Biol. 35: 493-500, 2008.
243. Y. Fujimura, P.M. Hwang, H. Trout, L. Kozloff, M. Imaizumi, R.B. Innis, and M. Fujita. Increased peripheral benzodiazepine receptors in arterial plaque of patients with atherosclerosis: an autoradiographic study with [3H]PK 11195. Atherosclerosis. 201: 108-111, 2008.
244. S.R. Donohue, S.S. Zoghbi, F. Yasuno, G. Terry, J.P. Gourley, R.B. Innis, C. Halldin,, and V.W. Pike. Radiosynthesis and evaluation in monkey of three 11C-labeled 1,5-diarylpyrazoles as high potency candidate PET radioligands for cannabinoid subtype-1 receptors in brain. Current Radiopharmaceuticals, 1, 93-102, 2008.
245. N. Seneca, S.S. Zoghbi, M. Skinbjerg, J.-S. Liow. J. Hong, D.R. Sibley, V.W. Pike, C. Halldin, and R.B. Innis. Occupancy of dopamine D2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA. Synapse. 62: 756-763, 2008.
246. N. Seneca, M. Skinbjerg, J.-S. Liow, R.L. Gladding, J. Hong, D. Sibley, C. Halldin, V.W. Pike, and R.B. Innis. Kinetic brain analysis and whole-body imaging in monkey of [11C]MNPA, a dopamine agonist radioligand. Synapse. 62: 700-709, 2008.
247. S.J. Finnema, S.R. Donohue, S.S. Zoghbi, A.K. Brown, B. Gulyas, R.B. Innis, C. Halldin, and V.W. Pike. Evaluation of [11C]PipISB and [18F]PipISB in monkey as candidate radioligands for imaging brain cannabinoid type-1 receptors in vivo. Synapse. 63: 22-30, 2009.
248. M. Schou, S.S. Zoghbi, H.U. Shetty, E. Shchukin, J.-S. Liow, J. Hong, B.A. Andree, B. Gulyas, L. Farde, R.B. Innis, V.W. Pike, and C. Halldin. Investigation of the metabolites of (S,S)- [11C]MeNER in humans, monkeys and rats. Mol. Imaging Biol. 11: 23-30, 2009.
249. N. Lazarova, S.S. Zoghbi, J. Hong, N. Seneca, E. Tuan, R.L. Gladding, J.-S. Liow, A. Taku, R.B. Innis, and V.W. Pike. Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. J. Med. Chem. 51: 6034-6043, 2008.
250. M. Tokunaga, N. Seneca, R.-M. Shin, J. Maeda, S. Obayashi, T. Okauchi, Y. Nagai, M.-R. Zhang, R. Nakao, H. Ito, R.B. Innis, C. Halldin, K. Suzuki, M. Higuchi, and T. Suhara. Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system. J. Neurosci. 29: 1887-1896, 2009.
251. M. Skinbjerg, Y. Namkung, C. Halldin, R.B. Innis, and D.R. Sibley. Pharmacological characterization of 2-methoxy-N-propylnorapomorphine’s interactions with D2 and D3 dopamine receptors. Synapse. 63: 462-475, 2009.
252. J.-S. Liow, W. Kreisl, S.S. Zoghbi, N. Lazarova, N. Seneca, R.L. Gladding, A. Taku, P. Herscovitch, V.W. Pike, and R.B. Innis. P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys. J. Nucl. Med. 50: 108-115, 2009.
253. A.K. Brown, Y. Kimura, S.S. Zoghbi, F.G. Siméon, J-S. Liow, W.C. Kreisl, A. Taku, M. Fujita, V.W. Pike, and R.B. Innis. Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PET. J. Nucl. Med. 49: 2042-2048, 2008.
254. H.U. Shetty, S.S. Zoghbi, F.G. Simeon, J.-S. Liow, A.K. Brown, P. Kannan, R.B. Innis, and V.W. Pike. Radiodefluorination of 3-Fluoro-5-(2-(2-([18F](fluoromethyl)-thiazol-4- yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat brain. J. Pharmacol Exp. Therap. 327: 727-735, 2008.
255. Y. Fujimura, F. Yasuno, A. Farris, J.-S. Liow, M. Geraci, W. Drevets, D.S. Pine, S. Ghose, A. Lerner, R. Hargreaves, H.D. Burns, C. Morse, V.W. Pike, and R.B. Innis. Decreased neurokinin- 1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ. Biol. Psychiatry. 66: 94-97, 2009.
256. M. Skinbjerg, M.A. Ariano, A. Thorsell, M. Heilig, C. Halldin, R.B. Innis, and D.R. Sibley. D2 dopamine receptor internalization is mediated by arrestin3. Synapse. 63: 621-624, 2009.
257. N. Seneca, L. Cai, J.-S. Liow, S.S. Zoghbi, R. Gladding, J.T. Little, P.S. Aisen, J. Hong, V.W. Pike, and R.B. Innis. Low retention of [S-methyl-11C]MeS-IMPY to ß-amyloid plaques in patients with Alzheimer's disease. Current Radiopharmaceuticals. 2: 129-136, 2009.
258. N. Seneca, S. S. Zoghbi, J.-S. Liow, W. Kreisl, P. Herscovitch, K. Jenko, R.L. Gladding, A. Taku, V.W. Pike, and R.B. Innis. Human brain imaging and radiation dosimetry of 11C-N- desmethyl-loperamide, a positron emission tomographic radiotracer to measure the function of P- glycoprotein. J. Nucl. Med. 50: 807-813, 2009.
259. E. Briard, S.S. Zoghbi, F.G. Simeon, M. Imaizumi, J.P. Gourley, H.U. Shetty, S. Lu, M. Fujita, R.B. Innis, and V.W. Pike. Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET. J Med Chem. 52: 688-699, 2009.
260. T. Itoh, K. Abe, S.S. Zoghbi, O. Inoue, J. Hong, M. Imaizumi, V.W. Pike, R.B. Innis, and M. Fujita. Positron emission tomographic measurement of the in vivo affinity of 11C-(R)-rolipram and the density of its target, phosphodiesterase-4, in brain of conscious and anesthetized rats. J. Nucl. Med. 50: 749-756, 2009.
261. Y. Fujimura, S.S. Zoghbi, F.G. Simeon, A. Taku, V.W. Pike, R.B. Innis, and M. Fujita. Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, 18F-PBR06. J. Nucl. Med. 50: 1047-1053, 2009.
262. S. Li, Y. Zhang, S. Wang, J. Yang, M. Ferraris Araneta, A. Farris, C. Johnson, S. Fox, R. Innis, and J. Shen. In vivo 13C magnetic resonance spectroscopy of human brain on a clinical 3 Tesla scanner using [2-13C]glucose infusion. Magnetic Resonance in Medicine. 62: 565-563, 2009.
263. W.C. Kreisl, G. Mbeo, M. Fujita, S.S. Zoghbi, V.W. Pike, R.B. Innis, and J.C. McArthur. Stroke incidentally identified with improved positron emission tomography for microglia activation. Arch. Neurol. 66: 1288-1289, 2009.
264. G. Terry, J.-S. Liow, S.S. Zoghbi, J. Hirvonen, A. Farris, A. Lerner, J. Tauscher, J. Schaus, L. Phebus, C. Felder, C. Morse, J. Hong, V.W. Pike, C. Halldin, and R.B. Innis. Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand. NeuroImage. 48: 362-370, 2009.
265. T. Itoh, K. Abe, J. Hong, O. Inoue, V.W. Pike, R.B. Innis, and M. Fujita. Effects of cAMP dependent protein kinase activator and inhibitor on in vivo PET rolipram binding to phosphodiesterase 4 in conscious rats. Synapse. 64: 172-176, 2010.
266. S. Lu, J-S. Liow, S.S. Zoghbi, J. Hong, R.B. Innis, and V.W. Pike. Evaluation of [11C]S14506 and [18F]S14506 in rat and monkey as agonist PET radioligands for brain 5-HT1A receptors. Current Radiopharmaceuticals. 3: 9-18, 2010.
267. G.E. Terry, J. Hirvonen, J-S. Liow, S.S. Zoghbi, R. Gladding, J.T. Tauscher, J.M. Schaus, L. Phebus, C.C. Felder, C.L. Morse, S.R. Donohue, V.W. Pike, C. Halldin, and R.B. Innis. Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands. J. Nucl. Med., 51: 112-120, 2010.
268. W.C. Kreisl, M. Fujita, Y. Fujimura, N. Kimura, K.J. Jenko, P. Kannan, J. Hong, C.L. Morse, S.S. Zoghbi, R.L. Gladding, S. Jacobson, U. Oh, V.W. Pike, and R.B. Innis. Comparison of
     [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission tomographic imaging of this inflammation biomarker. NeuroImage. 49: 2924-2932, 2010.
269. Y. Fujimura, Y. Kimura, F.G. Simeon, L.P. Dickstein, V.W. Pike, R.B. Innis, and M. Fujita. Biodistribution and radiation dosimetry in humans of a new PET ligand, 18F-PBR06, to image translocator protein (18 kDa). J. Nucl. Med. 51: 145-149, 2010.
270. G.E. Terry, J. Hirvonen, J.-S. Liow, N. Seneca, J.T. Tauscher, J.M. Schaus, L. Phebus, C.C. Felder, C.L. Morse, V.W. Pike, C. Halldin, and R.B. Innis. Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography. Eur. J. Nucl. Med. Mol. Imaging. 37: 1499-1506, 2010.
271. W.C. Kreisl, J.-S. Liow, N. Kimura, N. Seneca, S.S. Zoghbi, P. Herscovitch, V.W. Pike, and R.B. Innis. P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide. J. Nucl. Med. 51: 559-566, 2010.
272. M. Skinbjerg, J.-S. Liow, N. Seneca, J. Hong, S. Lu, A. Thorsell, M. Heilig, V.W. Pike, C. Halldin, D.R. Sibley, and R.B. Innis. D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model. NeuroImage. 50: 1402-1407, 2010.
273. M. Skinbjerg, N. Seneca, J.-S. Liow, J. Hong, D. Weinschenker, V.W. Pike, C. Halldin, D.R. Sibley, and R.B. Innis. Dopamine β-hydroxylase-deficient mice have normal densities of D2 dopamine receptors in the high affinity state based on in vivo PET and in vitro radioligand binding. Synapse. 64: 699-704, 2010.
274. H. Ozaki, S.S. Zoghbi, J. Hong, A. Verma, V.W. Pike, R.B. Innis, and M. Fujita. In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomography. Synapse. 64: 649-653, 2010.
275. Y. Kimura, F.G. Siméon, A.K. Brown, J.-S. Liow, R.L. Gladding, J. Hatazawa, M. G. Stabin, P.D. Mozley, V.W. Pike, R.B. Innis, and M. Fujita. Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humans. Eur. J. Nucl. Med. Mol. Imaging. 37: 1943-1949, 2010.
276. P. Kannan, K.R. Brimacombe, J.S. Liow, S.S. Zoghbi, C. Morse, A. Taku, V.W. Pike, C. Halldin, R.B. Innis, M.M. Gottesman, and M.D. Hall. N-Desmethyl-loperamide is selective for P- glycoprotein among three efflux transporters at the blood-brain barrier. Drug Metab. Disposition. 38: 917-922, 2010.
277. J. Hirvonen, G. Terry, C. Halldin, V. Pike, and R.B. Innis. Approaches to quantify radioligands that wash out slowly from target organs. Eur. J. Nucl. Med. Mol. Imaging. 37: 917-919, 2010.
278. S. Li, Y. Zhang, S. Wang, M. Ferraris Araneta, C.S. Johnson, Y. Xiang, R.B. Innis, and J. Shen. 13C MRS of occipital and frontal lobes at 3 T using a volume coil for stochastic proton decoupling. NMR in Biomedicine. 23: 977-985, 2010.
279. N. Seneca, S.S. Zoghbi, H.U. Shetty, E. Tuan, P. Kannan, A. Taku, R.B. Innis, and V.W. Pike. Effects of ketaconazole on biodistribution and metabolism of [11C]loperamide and [11C]N- desmethyl-loperamide in wild-type and P-gp knockout mice. Nucl. Med. Biol. 37: 335-345, 2010.
280. S. Lu, J. Hong, T. Itoh, M. Fujita, O. Inoue, R.B. Innis, and V.W. Pike. [carbonyl-11C]Benzyl acetate: automated radiosynthesis via Pd-mediated [11C]carbon monoxide chemistry and PET measurement of brain uptake in monkey. J. Labelled Compounds & Radiopharmaceuticals. 53: 548-551, 2010.
281. D.R. Owen, R.N. Gunn, E.A. Rabiner, I. Bennacef, M. Fujita, W.C. Kreisl, R.B. Innis, V.W. Pike, R. Reynolds, P.M. Matthews, and C.A. Parker. Mixed affinity binding in humans with 18 kDa translocator protein (TSPO) ligands. J. Nucl. Med. 52: 24-32, 2011.
282. L.P. Dickstein, S.S. Zoghbi, Y. Fujimura, M. Imaizumi, Y. Zhang, V.W. Pike, R.B. Innis, and M. Fujita. Comparison of 18F- and 11C-labelled aryloxyanilide analogs to measure translocator protein in human brain using positron emission tomography. Eur. J. Nucl. Med. Mol. Imaging. 38: 352-357, 2011.
283. P. Zanotti Fregonara, S.S. Zoghbi, J.-S. Liow, E. Luong, R. Boellaard, R.L. Gladding, V.W. Pike, R.B. Innis, and M. Fujita. Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function. NeuroImage, 283: 1903-1909, 2011.
284. P. Zanotti Fregonara, J.-S. Liow, M. Fujita, E. Dusch, S.S. Zoghbi, E. Luong, R. Boellaard, V.W. Pike, C. Comtat, and R.B. Innis. Image-derived input function for human brain using a high- resolution positron emission tomograph. PLOS ONE, 6(2): e17056, 2011.
285. V.W. Pike, S. Taliani, T.G. Lohith, D.R. Owen, I. Pugliesi, E. DaPozzo, J. Hong, S.S. Zoghbi, E.A. Rabiner, M. Fujita, R.B. Innis, C. Martini, and F. DaSettimo. Evaluation of novel N1- methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of TSPO-selective ligand suitable for the development of PET radioligands. J. Med. Chem. 54: 366-373, 2011.
286. U. Oh, M. Fujita, V.N. Ikonomidou, I.E. Evangelou, E. Matsuura, E. O’Keefe, J. Ohayon, N. Richert, V. Pike, Y. Zhang, S.S. Zoghbi, R. Innis, and S. Jacobson. Translocator protein positron emission tomography to image neuroinflammation in multiple sclerosis. J. Neuroimmune Pharmacol. 6: 354-361, 2011.
287. P. Kannan, S. Telu, S. Shukla, S.V. Ambudkar, V.W. Pike, C. Halldin, M.M. Gottesman, R.B. Innis, and M.D. Hall. The “specific” ABCB1 inhibitor tariquidar is also a substrate and an inhibitor for ABCG2. ACS Chemical Neuroscience. 2: 82-89, 2011.
288. P. Kannan, K.R. Brimacombe, W.C. Kreisl, J.-S. Liow, S.S. Zoghbi, S. Telu, Y. Zhang, V.W. Pike, C. Halldin, M.M. Gottesman, R.B. Innis, and M.D. Hall. Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET. Proc. Natl. Acad. Sci. USA. 108: 2593–2598, 2011.
289. V.W. Pike, K.S. Rash, Z. Chen, C. Pedregal, M.A. Statnick, Y. Kimura, J. Hong, S.S. Zoghbi, M. Fujita, S.L. Gackenheimer, J.A. Tauscher, V.N. Barth, and R.B. Innis. Synthesis and evaluation of radioligands for imaging brain NOP receptors with positron emission tomography. J. Med. Chem. 54: 2687-2700, 2011.
290. J. Hirvonen, R.S. Goodwin, C.-T. Li, G.E. Terry, S.S. Zoghbi, C. Morse, V.W. Pike, N.D. Volkow, M.A. Huestis, and R.B. Innis. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in heavy cannabis users. Mol. Psychiatry. 17: 642-649, 2012.
291. Y. Kimura, M. Fujita, J. Hong, T.G. Lohith, R. Gladding, S.S. Zoghbi, J.A. Tauscher, K.S. Rash, Z. Chen, C. Pedregal, V.N. Barth, V.W. Pike, and R.B. Innis. Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide (NOP) receptors. J. Nucl. Med. 52: 1638-1645, 2011.
292. P. Zanotti-Fregonara, K. Chen, J.-S. Liow, M. Fujita, and R. Innis. Image-derived input function for neuroreceptor PET studies: many challenges and few opportunities. J. Cerebral Blood Flow Metab. 31: 1986-1998, 2011.
293. J. Hirvonen, W.C. Kreisl, M. Fujita, I. Dustin, S. Miranda, Y. Zhang, C. Morse, V.W. Pike, R.B. Innis, and W.H. Theodore. Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. J. Nucl. Med. 53: 234-240, 2012.
294. N. Seneca, S.J. Finnema, I. Laszlovszky, B. Kiss, A. Horvath, G. Pasztor, M. Kapas, I. Gyertyan, S. Farkas, R.B. Innis, C. Halldin, and B. Gulyas. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology. 218: 579- 587, 2011.
295. T.G. Lohith, S.S. Zoghbi, C.L. Morse, M.F. Araneta, V.N. Barth, N.A. Goebl, J.A. Tauscher, V.W. Pike, R.B. Innis, and M. Fujita. Brain and whole-body imaging of nociceptin/orphanin FQ peptide (NOP) receptors in humans using a novel PET ligand 11C-NOP-1A. J. Nucl. Med. 53: 385-392, 2012.
296. C.S. Hines, J.-S. Liow, P. Zanotti Fregonara, J. Hirvonen, C. Morse, V.W. Pike, and R.B. Innis. Human biodistribution and dosimetry of 11C-CUMI-101, an agonist radioligand for serotonin-1A receptors in brain. PLOS ONE, 6:e25309, 2011.
297. Y. Kimura, F.G. Simeon, S.S. Zoghbi, Y. Zhang, J. Hatazawa, V.W. Pike, R.B. Innis, and M. Fujita. Quantification of metabotropic glutamate subtype 5 receptors in brain by an equilibrium method using 18F-SP203. NeuroImage. 59: 2124–2130, 2012.
298. S.S. Zoghbi, K.B. Anderson, K.J. Jenko, D.A. Luckenbaugh, R.B. Innis, and V.W. Pike. On quantitative relationships between PET radiotracer lipophilicity and plasma free fraction in monkey and human. J. Pharmaceutical Sci. 101: 1028-1039, 2012.
299. X. Bao, S. Lu, J.-S. Liow, S.S. Zoghbi, K.J. Jenko, D.T. Clark, C.L. Morse, R.L. Gladding, R.B. Innis, and V.W. Pike. Radiosynthesis and evaluation of an 18F-labeled non-imidazole 2- aminoethylbenzofuran-based histamine receptor subtype-3 PET radioligand. J. Med. Chem. 55: 2406 – 2415, 2012.
300. P. Zanotti Fregonara and R.B. Innis. Suggested pathway to assess radiation safety of 11C-labeled PET tracers for first-in-human studies. Eur. J. Nucl. Med. Mol. Biol. 39: 396-398, 2012.
301. S. Li, Y. Zhang, M. Ferraris Araneta, Y. Xiang, C. Johnson, R. B. Innis, and J. Shen. In vivo detection of 13C isotopomer turnover in the human brain by sequential infusion of 13C labeled substrates. J. Magnetic Resonance. 218: 16-21, 2012.
302. X. Bao, S. Lu, J.-S. Liow, C.L. Morse, K.B. Anderson, S.S. Zoghbi, R.B. Innis, and V.W. Pike. [11C]Rhodamine-123: synthesis and biodistribution in rodents. Nucl. Med. Biol. 39: 1128-1136, 2012.
303. P. Zanotti-Fregonara, J.-S. Liow, C. Comtat, S.S. Zoghbi, Y. Zhang, V.W. Pike, M. Fujita, and R.B. Innis. Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts. Nucl. Med. Comm. 33(9): 982-989, 2012.
304. M. Fujita, C.S. Hines, S.S. Zoghbi, A.G. Mallinger, L.P. Dickstein, J.-S. Liow, Y. Zhang, V.W. Pike, W.C. Drevets, R.B. Innis, and C.A. Zarate Jr. Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder. Biol. Psych. 72: 548-554, 2012.
305. J. Hirvonen, P. Zanotti Fregonara, J.C. Umhau, D.T. George, D. Rallis-Frutos, C.H. Lyoo, C.-T. Li, C.S. Hines, H. Sun, G.E. Terry, C. Morse, S.S. Zoghbi, V.W. Pike, R.B. Innis, and M. Heilig. Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. Mol. Psychiatry 18: 916-921, 2013.
306. J. Tam, R. Cinar, J. Liu, G. Godlewski, D. Wesley, T. Jourdan, G. Szanda, B. Mukhopadhyay, L. Chedester, J.-S. Liow, R.B. Innis, K. Cheng, K.C. Rice, J.R. Deschamps, R.J. Chorvat, J.F. McElroy, and G. Kunos. Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. Cell Metabolism 16: 167-179, 2012.
307. P. Zanotti-Fregonara, C.S. Hines, S.S. Zoghbi, J.-S. Liow, Y. Zhang, V.W. Pike, W.C. Drevets, A.G. Mallinger, C.A. Zarate Jr., M. Fujita, and R.B. Innis. Population-based input function and image-derived input function for [11C](R)-rolipram PET imaging: methodology, validation and application to the study of major depressive disorder. NeuroImage. 63: 1532-1541, 2012.
308. F.G. Simeon, J.-S. Liow, Y. Zhang, J. Hong, R.L. Gladding, S.S. Zoghbi, R.B. Innis, and V.W. Pike. Synthesis and characterization in monkey of [11C]SP203 as a radioligand for imaging brain metabotropic glutamate 5 receptors. Eur. J. Nucl. Med. Mol. Imaging. 39: 1949-1958, 2012.
309. K.J. Jenko, J. Hirvonen, I.D. Henter, K.B. Anderson, S.S. Zoghbi, T.M. Hyde, A. Deep-Soboslay, R.B. Innis, and J.E. Kleinman. Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia. Schizophrenia Research. 141: 185-188, 2012.
310. W.C. Kreisl, K.J. Jenko, C.S. Hines, C.H. Lyoo, W. Corona, C.L. Morse, S.S. Zoghbi, T. Hyde, J.E. Kleinman, V.W. Pike, F.J. McMahon, and R.B. Innis. A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J. Cereb. Blood Flow Metab. 33: 53-58, 2013.
311. P. Zanotti-Fregonara, V. Barth, J.-S. Liow, S.S. Zoghbi, D. Clark, E. Rhoads, E. Siuda, B.A. Heinz, E. Nisenbaum, B. Dressman, E. Joshi, D. Luffer-Atlas, M.J. Fisher, J. Master, N. Goebl, S. Kuklish, C. Morse, J. Tauscher, V.W. Pike, and R.B. Innis. Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for the metabotropic glutamate receptor 1 in brain. Eur. J. Nucl. Med. Mol. Imaging. 40: 245-253, 2013.
312. C.S. Hines, M. Fujita, S.S. Zoghbi, J.S. Kim, Z. Quezado, N. Miao, M.D. Ferraris Araneta, C. Morse, P. Herscovitch, V.W. Pike, J. Labovsky, and R.B. Innis. Propofol decreases in vivo binding of [11C]PBR28 to translocator protein (18kDa) in the human brain. J. Nucl. Med. 54: 64- 69, 2013.
313. T.G. Lohith, E.K. Osterweil, M. Fujita, K.J. Jenko, M.F. Bear, and R.B. Innis. Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? Molecular Autism. 4:15. http://www.molecularautism.com/content/4/1/15 
314. P. Kannan, V.W. Pike, C. Halldin, O. Langer, M.M. Gottesman, R.B. Innis, and M.D. Hall. Factors that limit positron emission tomography imaging of P-glycoprotein density at the blood- brain barrier. Mol. Pharmaceutics. 10: 2222-2229, 2013.
315. P. Zanotti-Fregonara, J. Hirvonen, C.H. Lyoo, S.S. Zoghbi, D. Rallis-Frutos, M.A. Huestis, C. Morse, V.W. Pike, and R.B. Innis. Population-based input function modeling for [18F]FMPEP-d2, an inverse agonist radioligand for cannabinoid CB1 receptors: validation in clinical studies. PLOS ONE, 8(4): 360231, 2013.
316. W.C. Kreisl, C.H. Lyoo, M. McGwier, J. Snow, K.J. Jenko, N. Kimura, W. Corona, C.L. Morse, S.S. Zoghbi, V.W. Pike, F.J. McMahon, R.S. Turner, R.B. Innis, and the Biomarkers Consortium PET Radioligand Project Team. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease. Brain, 136: 2228-2238, 2013.
317. W.M. Bosker, E.L. Karschner, D. Lee, R.S. Goodwin, J. Hirvonen, R.B. Innis, E.L. Theunissen, K.P.C. Kuypers, M.A. Huestis, and J.G. Ramaekers. Psychomotor function in chronic daily cannabis smokers during sustained abstinence. PLOS ONE, 8(1): e53127, 2013.
318. P. Zanotti-Fregonara, V.N. Barth, S.S. Zoghbi, J.-S. Liow, E. Nisenbaum, E.Siuda, R.L. Gladding, D. Rallis-Frutos, C. Morse, J. Tauscher, V.W. Pike, and R.B. Innis. 11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brain. EJNMMI Res. 3:47, 2013.
319. P. Zanotti-Fregonara, A.A. Lammertsma, and R.B. Innis. Suggested pathway to assess radiation safety of 18F-labeled PET tracers for first-in-human studies. Eur. J. Nucl. Med. Mol. Imaging. 40: 1781-1783, 2013.
320. R. Xu, P. Zanotti-Fregonara, S.S. Zoghbi, R.L. Gladding, A.E. Woock, R.B. Innis and V.W. Pike. Synthesis and evaluation in monkey of [18F]4-Fluoro-N-methyl-N-(4-(6- (methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([18F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1). J Med. Chem. 56: 9146- 9155, 2013.
321. M. Fujita, S. Mahanty, S.S. Zoghbi, M.D.F. Araneta, J. Hong, V.W. Pike, R.B. Innis, and T.E. Nash. PET reveals inflammation around calcified taenia solium granulomas with perilesional edema. PLOS ONE, 8(9): e74052, 2013.
322. S. Shrestha, E.E. Nelson, J.-S. Liow, R. Gladding, C.H. Lyoo, P.L. Noble, C. Morse, I.D. Henter, J. Kruger, B. Zhang, S.J. Suomi, P. Svenningsson, V.W. Pike, J.T. Winslow, E. Leibenluft, D.S. Pine, and R.B Innis. Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior. Am. J. Psychiatry. 171: 323-331, 2014.
323. S. Shrestha, J.-S. Liow, S. Lu, K. Jenko, R.L. Gladding, P. Svenningsson, C.L. Morse, S.S. Zoghbi, V.W. Pike, and R.B. Innis. [11C]CUMI-101, a positron emission tomographic radioligand, behaves as a serotonin 1A receptor antagonist and also binds to α1-adrenoceptors in brain. J. Nucl. Med. 55: 141-146, 2014.
324. T.G. Lohith, S.S. Zoghbi, C.L. Morse, M.F. Araneta, V.N. Barth, N.A. Goebl, J.A. Tauscher, V.W. Pike, R.B. Innis, and M. Fujita. Retest imaging of [11C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans. NeuroImage 87: 89-95, 2014.
325. T. Tsujikawa, S.S. Zoghbi, J. Hong, S.R. Donohue, K.J. Jenko, Robert L. Gladding, C. Halldin V.W. Pike, R.B. Innis and M. Fujita. In vitro and in vivo evaluation of 11C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors. NeuroImage 84: 733-741, 2014.
326. S.S. Shrestha, D.S. Pine, D.A. Luckenbaugh, K. Varnas, I.D. Henter, R.B. Innis, A.A. Mathe, and P. Svenningsson. Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model. Neurosci Letts. 559: 163-168, 2014.
327. C.H. Lyoo, P. Zanotti-Fregonara, S.S. Zoghbi, J.-S. Liow, R. Xu, V.W. Pike, C.A. Zarate, Jr., M. Fujita, and R.B. Innis. Image-derived input function derived from a supervised clustering algorithm: methodology and validation in a clinical protocol using [11C](R)-rolipram. PLOS ONE, 9(2): e89101, 2014.
328. N.J. Lodge, Y.-W. Li, F.T. Chin, D.D. Dischino, S.S. Zoghbi, J.A. Deskus, R.J. Mattson, M. Imaizumi, R. Pieschl, T.F. Molski, M. Fujita, H. Dulac, R. Zaczek, J.J. Bronson, J.E. Macor, R.B. Innis, V.W. Pike. Synthesis and evaluation of candidate PET radioligands for corticotrophin- releasing factor type-1 receptors. Nucl. Med. Biol. 41: 524-535, 2014.
329. C. Brouwer, K. Jenko, S.S. Zoghbi, R.B. Innis, and V.W. Pike. Development of N-methyl-(2- arylquinolin-4-yl)oxypropanamides as leads to PET radioligands for translocator protein (18 kDa). J. Med. Chem. 57: 6240-4251, 2014.
330. P. Zanotti-Fregonara, C.H. Lyoo, A. Bar-Hen, J.-S. Liow, S.S. Zoghbi, M. Fujita, R.B. Innis. Application of calibrated image derived input function to a clinical protocol. Nucl. Med. Comm., 35: 1188-1190, 2014.
331. P. Zanotti-Fregonara, Y. Zhang, K.J. Jenko, R.L. Gladding, S.S. Zoghbi, M. Fujita, G. Sbardella, S. Castellano, S. Taliani, C. Martini, R.B. Innis, F. Da Settimo, and V.W. Pike. Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single nucleotide polymorphism rs6971. ACS Chemical Neuroscience, 10: 963-971, 2014.
332. T.G. Lohith, R. Xu, T. Tsujikawa, C.L. Morse, K.B. Anderson, R.L. Gladding, S.S. Zoghbi, M. Fujita, R.B. Innis, and V.W. Pike. Evaluation in monkey of two candidate PET radioligands, [11C]RX-1 and [18F]RX-2, for imaging brain 5-HT4 receptors. Synapse, 68: 613-623, 2014.
333. W.C. Kreisl, R. Bhatia, C.L. Morse, A.E. Woock, S.S. Zoghbi, H.U. Shetty, V.W. Pike, and R.B. Innis. Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar. J. Nucl Med. 56: 82-87, 2015. doi: 10.2967/jnumed.114.146894
334. L.D. Gershen, P. Zanotti-Fregonara, I.H. Dustin, J.-S. Liow, J. Hirvonen, W.C. Kreisl, K.J. Jenko, S.K. Inati, M. Fujita, C.L. Morse, C. Brouwer, J.S. Hong, V.W. Pike, S.S. Zoghbi, R.B. Innis, and W.H. Theodore. Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein. JAMA Neurol., 72: 882-888, 2015. doi: 10.1001/jamaneurol.2015.0941
335. C.H. Lyoo, M. Ikawa, J.-S. Liow, S.S. Zoghbi, C.L. Morse, V.W. Pike, M. Fujita, R.B. Innis, and W.C. Kreisl. Cerebellum can serve as a pseudo-reference region in Alzheimer’s disease to detect neuroinflammation measured with PET radioligand binding to translocator protein. J Nucl. Med. 56: 701-706, 2015. doi: 10.2967/jnumed.114.146027
336. L.D. Weidner, S.S. Zoghbi, S. Lu, S. Shukla, S.V. Ambudkar, V.W. Pike, J. Mulder, M.M. Gottesman, R.B. Innis, and M.D. Hall. The inhibitor Ko143 is not specific for ABCG2. J. Pharmacol. Exp. Therap., 354: 384-93, 2015. doi: 10.1124/jpet.115.225482
337. J. Hong, S. Lu, R. Xu, J.-S. Liow, A.E. Woock, K.J. Jenko, R.L. Gladding, S.S. Zoghbi, R.B. Innis, and V.W. Pike. [carbonyl-11C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4- yl)thiazol-2-yl)benzamide ([11C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain. Nucl. Med. Biol., 42: 967-974, 2015. doi: 10.1016/j.nucmedbio.2015.07.006
338. G.R. Naumiec, K.J. Jenko, S.S. Zoghbi, R.B. Innis, L. Cai, V.W. Pike. N’-3- (Trifluoromethyl)phenyl derivatives of N-aryl –N’-methylguanidines as prospective PET radioligands for the open channel of the N-Methyl-D-asparate (NMDA) receptor: synthesis and structure-affinity relationships. J. Med. Chem., 58: 9722-9730, 2015. doi: 10.1021/acs.jmedchem.5b01510
339. P. Zanotti-Fregonara, R. Xu, S.S. Zoghbi, J.-S. Liow, M. Fujita, M. Veronese, R.L. Gladding, D. Rallis-Frutos, J. Hong, V.W. Pike, and R.B. Innis. The PET radioligand 18F-FIMX images and quantifies metabotropic glutamate receptor 1 in proportion to the regional density of its gene transcript in human brain. J. Nucl. Med., 57: 242-247, 2016. doi: 10.2967/jnumed.115.162461
340. L.D. Weidner, K.-L. Fung, P. Kannan, J. Moen, J. Kumar, J. Mulder, R.B. Innis, M.M. Gottesman, and M.D. Hall. Tariquidar is an inhibitor and not a substrate of human and mouse P- glycoprotein. Drug Metab. Dispos., 44: 275-282, 2016. doi: 10.1124/dmd.115.067785
341. M. Veronese, P. Zanotti-Fregonara, G. Rizzo, A. Bertoldo, R.B. Innis, and F.E. Turkheimer. Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: the genomic plot. NeuroImage, 130: 1-12, 2016. doi: 10.1016/j.neuroimage.2016.01.058
342. W.C. Kreisl, C.H. Lyoo, J.-S. Liow, M. Wei, J. Snow, E. Page, K.J. Jenko, C.L. Morse, S.S. Zoghbi, V.W. Pike, R.S. Turner, and R.B. Innis. 11C-PBR28 binding to translocator protein increases with progression of Alzheimer’s disease. Neurobiol. Aging, 44: 53-61, 2016. doi: 10.1016/j.neurobiolaging.2016.04.011
343. R. Cinar, M.R. Iyer, Z. Liu, Z. Cao, T. Jourdan, K. Erdelyi, G. Godlewski, G. Szanda, J. Liu, J.K. Park, B. Mukhopadhyay, A.Z. Rosenberg, J.-S. Liow, R.G. Lorenz, P. Pacher, R.B. Innis, and G. Kunos. Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis. JCI Insight, 1: pii:387336, 2016. doi:10.1172/jci.insight.87336
344. S.S. Shrestha, J.-S. Liow, K. Jenko, M. Ikawa, S.S. Zoghbi, and R.B. Innis. The 5-HT1A receptor PET radioligand 11C-CUMI-101 has significant binding to α1-adrenoceptors in human cerebellum, limiting its use as a reference region. J. Nucl. Med., 57:1945-1948, 2016. doi: 10.2967/jnumed.116.174151
345. J.-S. Liow, S.S. Zoghbi, S. Hu, M.D. Hall, C.S. Hines, H.U. Shetty, M.D. Araneta, E.M. Page, V.W. Pike, W.C. Kreisl, P. Hersocovitch, M.M. Gottesman, W.H. Theodore, and R.B. Innis.
     18F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier. NeuroImage 138: 134-140, 2016. doi: 10.1016/j.neuroimage.2016.05.045
346. C. Brouwer, K.J. Jenko, S.S. Zoghbi, C.L. Morse, R.B. Innis, and V.W. Pike. Translocator protein ligands based on N-methyl-(quinolin-4-yl)oxypropanamides with properties suitable for PET radioligand development. Eur. J. Med. Chem. 124: 677-688, 2016. doi: 10.1016/j.ejmech.2016.08.046
347. P. Kannan, M. Schain, W. Kretzschmar, L. Deuitch, N. Mitsios, B. Gulyas, H. Blom, M. Gottesman, R.B. Innis, M.D. Hall, and J. Mulder. An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter. J. Cereb. Blood Flow Metab. 37: 2062-2075, 2017. doi: 10.1177/0271678X16660984
348. M. Fujita, E.M. Richards, M. Niciu, S.S. Zoghbi, J. Hong, S. Telu, C.S. Hines, V.W. Pike, C.A. Zarate Jr, and R.B. Innis. cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor. Mol. Psychiatry, 22: 754-759, 2017. doi: 10.1038/mp.2016.171
349. T.G. Lohith, T. Tsujikawa, F.G. Simeon, M. Veronese, S.S. Zoghbi, C.H. Lyoo, Y. Kimura, C.L., Morse, V.W. Pike, M. Fujita, and R.B. Innis. Comparison of two PET radioligands, [11C]FPEB and [11C]SP203, for quantification of metabotropic glutamate receptor 5 in human brain. J. Cereb. Blood Flow Metab. 37: 2458-2470, 2017. doi: 10.1177/0271678X16668891
350. W.C. Kreisl, C.H. Lyoo, J.-S. Liow, J. Snow, E. Page, K.J. Jenko, C.L. Morse, S.S. Zoghbi, V.W. Pike, R.S. Turner, R.B. Innis. Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer’s disease. Neurobiol Aging, 51: 132-140, 2017. doi: 10.1016/j.neurobiolaging.2016.12.006
351. M. Ikawa, T.G. Lohith, S. Shrestha, S. Telu, S.S. Zoghbi, S. Castellano, S. Taliani, F. Da Settimo, M. Fujita, V.W. Pike R.B. Innis, and the Biomarkers Consortium PET Radioligand Project Team. 11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain. J. Nucl. Med. 58:320-325, 2017. doi: 10.2967/jnumed.116.178996
352. W.C. Kreisl, R. Lawrence, E. Page, A.F. Teich, D.S. Subramaniam, R.B. Innis, and R.S. Turner. 11C-PBR28 PET detects translocator protein in a patient with astrocytoma and Alzheimer’s disease. Neurology. 88: 1001-1004, 2017. doi: 10.1212/WNL.0000000000003693
353. F.A. Schroeder, T.M. Gilbert, N. Feng, B.D. Taillon, N.D. Volkow, R.B. Innis, J.M. Hooker, and B.K. Lipska. Expression of HDAC2 but not HDAC1 transcript is reduced in dorsolateral prefrontal cortex of patients with schizophrenia. ACS Chemical Neuroscience. 8: 662-668, 2017. doi: 10.1021/acschemneuro.6b00372
354. M. Fujita, M. Kobayashi, M. Ikawa, R.N. Gunn, E.A. Rabiner, D.R. Owen, S.S. Zoghbi, M.B. Haskali, S. Telu, V.W. Pike, and R.B. Innis. Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176. EJNMMI Res. 7:84, 2017. doi: 10.1186/s13550-017-0334-8
355. M.J. Fisher, L. McMurray, S. Lu, C.L. Morse, J.-S. Liow, S.S. Zoghbi, A. Kowalski, G.L. Tye, R.B. Innis, F.I. Aigbirhio, and V.W. Pike. [Carboxyl-11C]-labelling of four high-affinity cPLA2α inhibitors and their evaluation as radioligands in mice by positron emission tomography. ChemMedChem. 13: 138-146, 2018. doi: 10.1002/cmdc.201700697
356. M. Kobayashi, T. Jiang, S. Telu, S.S. Zoghbi, R.N. Gunn, E.A. Rabiner, D.R. Owen, Q. Guo, V.W. Pike, R.B. Innis, and M. Fujita. 11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-(R)-PK11195. J. Cereb. Blood Flow Metab. 38 (3): 393-403, 2018. doi: 10.1177/0271678X17699223
357. S.W. Kim, C.E. Wiers, R. Tyler, E. Shokri-Kojori, Y.J. Jang, A. Zehra, C. Freeman, V. Ramirez, E. Lindgren, G. Miller, E. Cabrera, T. Stodden, M. Guo, S.B. Demiral, N. Diazgranados, L. Park, J.-S. Liow, V. Pike, C. Morse, L. Vendruscolo, R.B. Innis, G.F. Koob, D. Tomasi, G.-J. Wang, N.D. Volkow. Translocator protein expression in alcoholism and the role of cholesterol: brain [11C]PBR28 PET study in humans and rodents. Neuropsychopharmacology 43:1832-1839, 2018. doi: 10.1038/s41386-018-0085-x
358. M. Ooms, T. Tsujikawa, T.G. Lohith, S.N. Mabins, S.S. Zoghbi, A. Sumitomo, H. Jaaro-Peled, Y. Kimura, S. Telu, V.W. Pike, T. Tomoda, R.B. Innis, A. Sawa, and M. Fujita. [11C](R)- Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice. J. Cereb. Blood Flow Metab. 39:1138-1147, 2019. doi: 10.1177/0271678X18758997
359. P. Singh, S.S. Shrestha, M.Y. Cortes-Salva, K.J. Jenko, S.S. Zoghbi, C.L. Morse, R.B. Innis, and V.W. Pike. 3-substituted 1-5-Diaryl H-1,2,4-triazoles as prospective PET radioligands for imaging brain COX-1 in monkey. Part 1: Synthesis and Pharmacology. ACS Chem. Neurosci. 9: 2610-2619, 2018. doi: 10.1021/acschemneuro.8b00102
360. S. Shrestha, P. Singh, M.Y. Cortes-Salva, K.J. Jenko, M. Ikawa, M.-J. Kim, M. Kobayashi, C.L. Morse, R.L. Gladding, J.S. Liow, S.S. Zoghbi, M. Fujita, R.B. Innis, and V.W. Pike. 3- Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as PET radioligands for imaging brain COX-1 in monkey. Part 2: Selection and evaluation of [11C]PS13 for quantitative imaging. ACS Chem. Neurosci. 9: 2620-2627, 2018. doi: 10.1021/acschemneuro.8b00103
361. M.-J. Kim, S.S.Shrestha, M. Cortes, P. Singh, C. Morse, J.-S. Liow, R.L. Gladding, C. Brouwer, K. Henry, E. Gallagher, G.L. Tye, S.S. Zoghbi, M. Fujita, V.W. Pike, and R.B. Innis. Evaluation of two potent and selective PET radioligands to image COX-1 and COX-2 in rhesus monkeys J. Nucl. Med., 59: 1907-1912, 2018. doi: 10.2967/jnumed.118.211144
362. L.D. Weidner, P. Kannan, N. Mitsios, S.J. Kang, M.D. Hall, W.H. Theodore, R.B. Innis, J. Mulder. The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue. Epilepsia 59: 1507-1517, 2018. doi: 10.1111/epi.14505
363. E.M. Richards, P. Zanotti-Fregonara, M. Fujita, L. Newma, C. Farmer, E.D. Ballard, R. Machado-Vieira, P. Yuan, M.J. Niciu, I.D. Henter, G. Salvadore, W.C. Drevets, H. Kolb, R.B. Innis, and C.A. Zarate. PET radioligand binding to translocator protein (TSPO), is increased in unmedicated depressed subjects. EJNMMI Res, 8: 57, 2018. doi: 10.1186/s13550-018-0401-9
364. S. Paul, M.B. Haskali, J.-S. Liow, S.S. Zoghbi, S. Dubois, V.N. Barth, M. Comly Kolodrubetz, M.R. Bond, C.L. Morse, R.L. Gladding, N. Kant, S. Shcherbinin, H.N. Nuthall, J.A. Hanover, C. Jesudason, V.W. Pike, and R.B. Innis. Evaluation of a novel PET radioligand to image O- GlcNAcase in brain and periphery of rhesus monkey and knock out mouse. J. Nucl. Med. 60: 129-134, 2019. doi: 10.1177/0271678X18771250
365. J. Hirvonen, P. Zanotti-Fregonara, D.A. Gorelick, C.H. Lyoo, D. Rallis-Frutos, C. Morse, S.S. Zoghbi, V.W. Pike, N.D. Volkow, M.A. Huestis, and R.B. Innis. Decreased cannabinoid CB1 receptors in male tobacco smokers examined with positron emission tomography. Biol. Psychiatry 84: 715-721, 2018. doi: 10.1016/j.biopsych.2018.07.009
366. M.Y. Cortes-Salva, S. Shrestha, P. Singh, C.L. Morse, K.J. Jenko, J.A. Montero Santamaria, S.S. Zoghbi, R.B. Innis, and V.W. Pike. 2-(4-Methylsulfonylphenyl)pyrimidines as prospective radioligands for imaging cyclooxygenase-2 with PET--Synthesis, triage, and radiolabeling. Molecules 23: pii: E2850, 2018. doi: 10.3390/molecules23112850
367. A. Lindberg, S. Lu, S. Nag, M. Schou, J.-S. Liow, S.S. Zoghbi, M.P. Frankland, R.L. Gladding, C.L. Morse, C.S. Elmore, Y.S. Lee, R.B. Innis, C. Halldin, and V.W. Pike. Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors. Nucl Med Biol. 70: 1-13, 2019. doi: 10.1016/j.nucmedbio.2019.01.005
368. J.-S. Liow, C.L. Morse, S.Y. Lu, M. Frankland, G.L. Tye, S.S. Zoghbi, R.L. Gladding, A.B. Shaik, R.B. Innis, A.H. Newman, V.W. Pike. [O-methyl-11C]N-(4-(4-(3-Chloro-2- methoxyphenyl) piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([11C]BAK4-51) is an efflux transporter substrate and ineffective for PET imaging of brain D3 receptors in rodents and monkey. Molecules, 23: 2737. 2018. doi: 10.3390/molecules23112737.
369. P. Zanotti-Fregonara, W.C. Kreisl, R.B. Innis, and C.H. Lyoo. Automatic extraction of a reference region for the noninvasive quantification of translocator protein in brain using 11C- PBR28. J. Nucl. Med. 60: 978-984, 2019. doi: 10.2967/jnumed.118.222927
370. M.J. Kim, M. McGwier, K.J. Jenko, J. Snow, C. Morse, S.S. Zoghbi, V.W. Pike, R.B. Innis, W.C. Kreisl. Neuroinflammation in frontotemporal lobar degeneration revealed by 11C-PBR28 PET. Ann. Clin. Transl. Neurol. 6: 1327-1331, 2019. doi: 10.1002/acn3.50802
371. S. Paul, E. Gallagher, J.S. Liow, S. Mabins, K. Henry, S.S. Zoghbi, R.N. Gunn, W.C. Kreisl, E.M. Richards, P. Zanotti-Fregonara, C.L. Morse, J. Hong, A. Kowalski, V.W. Pike, R.B. Innis, Fujita. Building a database for 18 kDa translocator protein imaged using [11C]PBR28 in healthy subjects. J. Cereb. Blood Flow Metab. 39: 1138-1147, 2019. doi: 10.1177/0271678X18771250
372. G.M. Knudsen, 42 middle authors, and R.B. Innis. Guidelines for the content and format of PET brain data in publications and archives: A consensus paper. J. Cereb. Blood Flow Metab. Feb 17, 2020 [epub ahead of print] doi: https://doi.org/10.1177/0271678X20905433.
373. L. Cai, J.-S. Liow, C.L. Morse, S. Telu, R. Davies, M.P. Frankland, S.S. Zoghbi, K. Cheng, M.D. Hall, R.B. Innis, and V.W. Pike. Evaluation of [11C]NR2B-SMe and its enantiomers as radioligands for imaging the NR2B subunit within the NMDA receptor complex in rats. J. Nucl. Med. Jan 10, 2020 [epub ahead of print] doi: 10.2967/jnumed.119.235143.
374. L.D. Weidner, Y. Wakabayashi, L.A. Stolz, M.T. Collins, L. Guthrie, M. Victorino, J. Chung, W. Miller, S.S. Zoghbi, V.W. Pike, M. Fujita, R.B. Innis, and A.M. Boyce. PET imaging of phosphodiesterase-4 identifies affected dysplastic bone in McCune-Albright syndrome, a genetic mosaic disorder. J. Nucl. Med. April 13, 2020 [epub ahead of print] doi: 10.2967/jnumed.120.241976.
375. J.-H. Lee, J.-S. Liow, S. Paul, C.L. Morse, M.B. Haskali, L. Manly, S. Shcherbinin, J.C. Ruble,
376. Kant, E.C. Collins, H.N. Nuthall, P. Zanotti-Fregonara, S.S. Zoghbi, V.W. Pike, and R.B. Innis. PET quantification of brain O-GlcNAcase with [18F]LSN3316612 in healthy human volunteers EJNMMI Research. March 14, 2020 [epub ahead of print] doi:10.1186/s13550-020- 0616-4.
377. Y. Wakabayashi, S. Telu, R.M. Dick, M. Fujita, M. Ooms, C.L. Morse, J.-S. Liow, J.S. Hong, R.L. Gladding, L.S. Manly, S.S. Zoghbi, X. Mo, E.C. D’Amato, J.A. Sindac, R.A. Nugent, B.E. Marron, M.E. Gurney, R.B. Innis, and V.W. Pike. Discovery, radiolabeling, and evaluation of subtype-selective inhibitors for positron emission tomography imaging of brain phosphodiesterase-4D. ACS Chem. Neurosci. April 8, 2020 [epub ahead of print] doi: 10.1021/acschemneuro.0c00077
378. J. Meyer, S. Cervenka, M.-J. Kim, W.C. Kreisl, I.D. Henter, and R.B. Innis. Neuroinflammation in psychiatric disorders: PET imaging and promising new targets. Lancet Psychiatry. In press
379. S. Shrestha, M.-J. Kim, M. Eldridge, M.L. Lehmann, M. Frankland, J.-S. Liow, Z.-X. Yu, M. Cortes-Salve, S. Telu, I.D. Henter, E. Gallagher, J.-H. Lee, J.M. Fredericks, C. Poffenberger, G. Tye, Y. Ruiz-Perdomo, F. Juarez Anaya, J.A. Montero Santamaria, R.L. Gladding, S.S. Zoghbi, M. Fujita, J.D. Katz, V.W. Pike, and R.B. Innis. PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study. J. Neuroinflammation. In press.
380. M.-J. Kim, J.-H. Lee, F. Juarez Anaya, J. Hong, W. Miller, S. Telu, P. Singh, M.Y. Cortes, K. Henry, G.L. Tye, F.P. Frankland, J.A. Montero Santamaria, J.-S. Liow, S.S. Zoghbi, M. Fujita, V.W. Pike, and R.B. Innis. First-in human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in brain. EJNMMI. In Press.
381. H.U. Shetty, S.S. Zoghbi, C.L. Morse, A. Kowalski, J. Hirvonen, R.B. Innis, and V.W. Pike. Development of a non-radiometric method for measuring arterial input function of a 11C-labeled PET radiotracer. Scientific Reports. Submitted.
382. W.C. Kreisl, M.-J. Kim, J. Coughlin, I.D. Henter, D.R. Owen, and R.B. Innis. PET imaging of neuroinflammation in neurologic disorders. Lancet Neurology. Submitted.

REVIEWS AND BOOK CHAPTERS:
C1. S.H. Snyder, and R.B. Innis. Peptide neurotransmitters. Ann. Rev. Biochem., 48: 755-788, 1979.
C2. S.H. Snyder, R.B. Innis, and F.M.A. Correa. Distribution of cholecystokinin and bradykinin in rat brain. In: Role of Peptides in Neuronal Function, J. Baker and T.G. Smith, Jr. (eds.). Marcel Dekker, New York, pp. 375-388, 1980.
C3. R.B. Innis, and S.H. Snyder. Radioreceptor assay: techniques and applications to psychiatry. In: Clinical Pharmacology in Psychiatry, J. Davis and E. Usdin (eds.), Elsevier/North Holland, New York, pp. 103-120, 1980.
C4. R.B. Innis, and S.H. Snyder. Psychotropic drugs and neurotransmitter receptors: a) radioreceptor assays for neuroleptics and tricyclic antidepressants, b) antidepressants and neurotransmitter receptors, c) 3H-imipramine binding sites. In: Neuroreceptors: Basic and Clinical Aspects, E. Usdin, W.E. Bunney, and J.M. Davis (eds.), Wiley, New York, pp. 141-164, 1981.
C5. R.B. Innis, and S.H. Snyder. Cholecystokinin and bradykinin: putative peptide neurotransmitters.
In: Hormones and the Brain. D. de Wied and P. van Keep (eds.), MIT Press, London, 1980, pp. 53-62.
C6. R.B. Innis, and G.K. Aghajanian. Cholecystokinin: electrophysiologic and receptor auto- radiographic studies in rodent brain. In: Mechanism of Drug Action, Ondaraza, R.N. and Singer,
T.P. (eds.), Academic Press, pp. 375-386, 1983.
C7. R.B. Innis, M.A. Zarbin, M.J. Kuhar, and S.H. Snyder. Central and peripheral cholecystokinin receptors. In: Methods in Neurobiology, P.J. Marangos, I. Campbell, and R.H. Cohen, (eds.), Academic Press, New York, pp. 111-127, 1984.
C8. R.B. Innis, and G.K. Aghajanian. Cholecystokinin: Electrophysiologic and receptor autoradiographic studies in rodent brain. In: Mechanism of Drug Action, T.P. Singer,T.E.Mansour, and R.N. Ondarza (eds.) Academic Press, New York, pp. 375-386, 1983
C9. R.B. Innis, M.A. Zarbin, M.J. Kuhar, and S. Snyder. Central and peripheral CCK receptors. In: Brain Receptor Methodologies. Academic Press, New York, pp. 111-127, 1984.
C10. R.B. Innis, and G.K. Aghajanian. Integrated anatomical and physiological studies of neuronal cholecystokinin receptors. In: Neuronal Cholecystokinin, J.J. Vanderhaeghen and J.N. Crawley (eds.), Annals New York Academy of Sciences, 448:188-197, 1985.
C11. J.P. Seibyl, W.M. Glazer, and R.B. Innis. Serotonin function in tardive dyskinesia, Psychiatric Annals, 19: 310-314, 1989.
C12. R.B. Innis, E. Johnson, S. Woods, S. Zoghbi, P. Hoffer, G. Heninger. Evaluation of 123I-Ro16- 0154 as a SPECT Radioligand of the benzodiazepine (BZ) receptor in primate brain. Bottstein Colloquium: Iomazenil and other brain receptor tracers for SPECT, P. Schubiger and P. Hasler (eds.), F. Hoffmann-La Roche Ltd., Basel, pp. 31-32, 1990.
C13. M. Laruelle, E. Sybirska, M. Al-Tikriti, R.M. Baldwin, and R.B. Innis. SPECT imaging of the benzodiazepine receptor. In: Imaging in Alcohol Research, NIAAA Research Monograph 21, S. Zakhari and E. Witt (eds.), DHHS publication No. (ADM)92-18909, pp. 305-332, 1992.
C14. R.B. Innis. Neuroreceptor imaging with SPECT. J. Clin. Psychiatry, 53 (supplement): 29-34, 1992.
C15. M. Laruelle, R.M. Baldwin, and R.B. Innis. SPECT imaging of dopamine and serotonin transporters in nonhuman primate brain. In: NIDA Res. Monographs, 138: 131-159, 1994.
C16. R.T. Malison, and R.B. Innis. Principles of Neuroimaging, in Comprehensive Textbook of Psychiatry (6th edition), Kaplan, H.I. and Sadock, B.J. (eds), Williams and Wilkins, Baltimore, MD, 89-103, 1995.
C17. R.B. Innis. Principles of Neural Transmission Applied in Brain Imaging, in Principles of Nuclear Medicine, 2nd edition, H.N. Wagner, Z. Szabo, and J.W. Buchanan (eds), Saunders, Philadephia, PA, 497-504, 1995.
C18. R.T. Malison, M. Laruelle, and R.B. Innis. Positron and single photon emission computed tomography: principles and applications. In: Psychopharmacology: The Fourth Generation of Progress, Bloom, F.E and Kupfer, D.J. (eds.) Raven Press, pp. 865 - 880, 1994.
C19. R.B. Innis. SPECT imaging of dopamine terminal innervation: potential clinical tool in Parkinson’s disease. Eur. J. Nucl. Med., 21: 1-5, 1994.
C20. N.P.L.G. Verhoeff, J. Booij, R.B. Innis, and E.A. van Royen. Neuroreceptor ligand imaging by single photon emission computed tomography (SPECT) in Parkinsonian syndromes. In: A Textbook of SPECT in Neurology and Psychiatry, De Deyn PP, Dierckx RA, Alavi A, Pickut BA, (eds.). John Libbey Publishers, London, pp.149-165, 1997.
C21. R.B. Innis. SPECT imaging of dopaminergic function: presynaptic transporter, postsynaptic receptor, and "intrasynaptic” transmitter. Advances in Pharmacology, Vol 42: 215-218, 1998.
C22. J. P. Seibyl, E. Scanley, J. H. Krystal, and R. B. Innis. Neuroimaging Methodologies Utilizing Radiotracers or Nuclear Magnetic Resonance. In: Neurobiology Mental Illness, D.S. Charney,
E.J. Nestler, and B.S. Bunney (eds), Oxford University Press, New York, 170-194, 1999.
C23. R.T. Malison and R.B. Innis. Neuroimaging: Radiotracer Techniques, in Comprehensive Textbook of Psychiatry (7th edition), Kaplan, H.I. and Sadock, B.J. (eds), Williams and Wilkins, Baltimore, MD, 154-161, 1999.
C24. M. Laruelle, A. Abi-Dargham, and R.B. Innis. Imaging receptor occupancy by endogenous transmitters in humans. In: Quantitative Functional Brain Imaging with Positron Emission Tomography , R. Carson, M. Daube-Witherspoon, and P. Herscovitch (eds), Academic Press, San Diego, in press.
C25. J.K. Staley, R.T. Malison, and R.B. Innis. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biol. Psychiatry, 44: 534-549, 1998.
C26. J.C. Soares and R.B. Innis. Neurochemical brain imaging investigations of schizophrenia. Biol.
Psychiatry, 46: 600-615, 1999.
C27. J.C. Soares and R.B. Innis. Brain imaging findings in bipolar disorder. In: Bipolar Disorders: Basic Mechanisms and Therapeutic Implicatioins. J.C. Soares and S. Gershon (eds), Marcel Dekker, New York, pp. 227-252, 2000.
C28. M. Fujita and R.B. Innis. Nuclear Psychiatry: Specialty for the Twenty-first Century? Eur. J. Nucl. Med., 27: S39-S42, 2000.
C29. A. Kugaya, M. Fujita, and R.B. Innis. Applications of SPECT imaging of dopaminergic neurotransmission in neuropsychiatric disorders. Ann. Nucl. Med., 14: 1-9, 2000.
C30. M. Fujita, and R.B. Innis. In Vivo molecular imaging: ligand development and research applications. In: Psychopharmacology: The Fifth Generation of Progress. D. Charney, J.Coyle, K. Davis, and C. Nemeroff (eds), Raven Press, pp. 411-425, 2002.
C31 M. Fujita, D.S. Charney, and R.B. Innis. Imaging serotoninergic neurotransmission in depression: hippocampal pathophysiology may mirror global brain alterations. Biol. Psychiatry. 48: 801-812, 2000.
C32 R. Innis, S Ferguson, L Brady, R Esmond, and R Frank . Positron-emission tomography tracers as intellectual property. J. Clin. Pharmcology. 41: 107S-117S, 2001.
C33 J.P. Seibyl, B.E. Scanley, J.H. Krystal, and R.B. Innis. Neuroimaging methodologies utilizing radiotracers or nuclear magnetic resonance. In: Neurobiology of Mental Illness. D. Charney and
E. Nestler (eds), Oxford University Press, New York. pp. 190-209, 2004.
C34 M. Fujita, A. Kugaya, and R.B. Innis. Radiotracer Imaging: Basic Principles and Exemplary Findings in Neuropsychiatric Disorders. In Comprehensive Textbook of Psychiatry (8th edition), Kaplan, H.I. and Sadock, B.J. (eds), Williams and Wilkins, Baltimore, MD. pp. 222-235, 2005.
C35 M. Vythilingam, J. Shen, W. Drevets, and R.B. Innis. Nuclear Magnetic Resonance Imaging: Basic Principles and Exemplary Findings in Neuropsychiatric Disorders. In Comprehensive Textbook of Psychiatry (8th edition), Kaplan, H.I. and Sadock, B.J. (eds), Williams and Wilkins, Baltimore, MD. pp 201-221, 2005.
C36 R.B. Innis. Imaging dopamine neurotransmission in Parkinson's disease: biomarker versus surrogate endpoint. Dialogues in Clinical Neuroscience, 6: 312-313, 2004.
C37 B. Ravina et al. The role of radiotracer imaging in Parkinson disease Neurology 64: 208-215, 2005.
C38 L. Nichols, V.W. Pike, L. Cai, and R.B. Innis. In vivo imaging and quantitation of ß-amyloid in brain: An exemplary biomarker for Alzheimer's disease? Biol. Psychiatry. 59: 940-947, 2006.
C39 V.L. Cropley, M. Fujita, R.B. Innis, and P.J. Nathan. Molecular imaging of the dopaminergic system and its association with human cognitive function. Biol. Psychiatry. 59: 898-907, 2006.
C40 L. Cai, R.B. Innis, and V.W.Pike. Radioligand development for PET imaging of ß-amyloid (Aß)
– current status. Current Medicinal Chemistry, 14: 19-52, 2007.
C41 P. Kannan, C. John, S.S. Zoghbi, C. Halldin, M.M. Gottesman, R.B. Innis, and M.D. Hall.
Imaging the function of P-glycoprotein with radiolabeled substrates: pharmacokinetics and in vivo applications. Clin Pharmacology and Therapeutics, 86: 368-376, 2009.
C42 S. Shrestha, J. Hirvonen, C. Hines, I. Henter, V.W. Pike, P. Svenningsson, and R.B. Innis.
Serotonin-1A receptors in major depression quantified using PET: controversies, confounds, and recommendations. NeuroImage, 59: 3243-3251, 2012.
C43 W.C. Kreisl, I.D. Henter, R.B. Innis. Imaging translocator protein as a biomarker of neuroinflammation in dementia. In Gavril W. Pasternak, Joseph T. Coyle, editors: Apprentices to Genius: A tribute to Solomon H. Snyder, Vol 82, APHA, UK: Academic Press, 2018, pp. 163- 185.

GRANTS & CONTRACTS: Active at time of departure from Yale University (2001)

"Serotonin 5-HT2A Receptors in Depression.” NIMH R01 MH58620. PI: R. Innis. Annual direct costs:
$216,000. Total period (direct & indirect): $818,343; Expected funded period: 1/1/00 – 12/31/02. "Neuroimaging of Dopamine Transporters in Parkinson's Disease.” VA Merit Review. PI: R. Innis. Annual
direct costs: $129,900. Total period (direct & indirect): $447,700; 10/1/99- 8/31/02.
"VA Schizophrenia Research Center," PI: R. Innis. Annual direct costs: $400,000. Total period (direct & indirect): $1,700,000; 1/1/00-12/31/04.
"Neuroimaging Sciences Training Program.” NINDS T32 NS07416. PI: R. Innis. This institutional training grant will support 4 postdoctoral fellows per year for up to 2-3 years in areas of methodology and research imaging using nuclear magnetic resonance and radiotracer techniques. First year direct costs approximately $156,000. Total period (direct & indirect): $890,630; 7/1/97-6/30/02.
"SPECT Benzodiazepine Receptor and MR Imaging in PTSD.” VA Research Service. PI: R. Innis. Annual direct costs: $100,000. Total period (direct & indirect): $300,000; 4/1/99- 3/31/02.
"Neuronal Mechanisms and Treatment Response in Depression.” VA Research Enhancement Award Program (REAP). PI: R. Innis. Annual direct costs: $300,000. Total period (direct & indirect): $1,600,000; 1/1/99- 12/31/04.
"Mental Health Clinical Research Center." NIMH P30-MH30929. PI: G. Heninger. Dr. Innis directs the Laboratory of Neuroimaging on this competitive renewal. Annual direct costs for Laboratory: $100,000. Total period (direct & indirect): $490,500; 9/1/98-8/31/01.
"Transdisciplinary Tobacco Use Research Center." NIDA & NCI P50 DA84733. PI: S. O'Malley. Dr. Innis directs a project entitled "Imaging of Serotonergic and Cholinergic Markers in Smokers." Project annual direct: $220,000. Project total period (direct & indirect): $1,520,000; 10/1/99-9/30/04.
"Clinical Neuroscience Division for the National Center for Post-Traumatic Stress Disorder." VA. PI: J. Krystal.
Annual direct costs approx. $1.2M; total period (direct & indirect) ~$9M. Dr. Innis is Director of the Laboratory of Brain Imaging, annual direct costs, approx. $140,000; 5/1/89-without term;
"Epilepsy Research Center Program Project." NINDS P50 NS06208. PI: R. Mattson. Director of Imaging Project: R. Innis. Annual direct costs for imaging: $15,000. Total period (direct & indirect): $122,625; 9/1/97-8/31/02.
"VA Alcohol Research Center." Co-PI's: B. Rounsaville and J. Krystal. As Investigator, Dr. Innis directs the brain imaging studies, with an annual budget of $20,000. Total period (direct & indirect) $100,000; 2/1/99-1/31/04.
"Mental Illness: Research, Education, and Clinical Center" (MIRECC). VA. PI: B. Rounsaville. Dr. Innis directs a SPECT imaging project of dopaminergic transmission in dual diagnosis (cocaine addiction and schizophrenia). Project annual direct costs: $95,000. Total period (direct & indirect): $475,000; 9/1/97 - 8/31/02.
"Striatal and Extrastriatal Dopaminergic Neurotransmission in Schizophrenia." NIMH P50 MH44866. This project is directed by Dr. Innis and is part of the CNMD (Center for Neuroscience of Mental Disorders; PI: P.Goldman-Rakic). Project annual direct costs: $100,000. Project total period (direct & indirect):
$817,500; 9/1/98 - 8/31/03.
"Center for the Study of Borderline Personality Disorder." PI: T. McGlashan. Source: Swiss Foundation. Dr. Innis directs the PET neuroimaging Core. Annual direct costs for Core: ~$100,000. 1/1/00 – 1/1/05.
"Iodinated Imaging Agents for the Serotonin Transporter." Phase I SBIR (Small Business Innovative Research) application from RadioTracer, Inc. to NIMH. PI: R. Baldwin. Dr. Innis will direct the subcontract to Yale. Subcontract (6 mos.) direct costs: $10,716. Total period (direct & indirect): $15,548; 9/1/99 – 3/31/00.
"Technetium Radiotracers for the Dopamine Transporter." Phase II SBIR (Small Business Innovative Research) application from Department of Energy to RadioTracer, Inc. PI: R. Baldwin. Dr. Innis is President of RadioTracer, Inc. and will also direct the subcontract to Yale. Subcontract annual direct costs: $13,280.
Total period (direct and indirect): $38,514; 10/1/99-9/30/01.