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Molecular Imaging Branch

Fabrice Simeon, PhD

Fabrice Simeon, PhDDr. Fabrice Simeon, PhD is a Staff Scientist who joined the PET Radiopharmaceutical Sciences Section, Molecular Imaging Branch, National Institute of Mental Health as a Visiting Fellow in March 2003. He received his BSc (Organic Chemistry, 1993) and PhD (Synthetic Organic Chemistry, 1998) from the University of Caen, France. Dr. Simeon’s early research focused on the fast methods for the synthesis of organic molecules using either microwave irradiation or organometallic catalytic systems. Before joining the MIB in Bethesda, MD, he spent two years at the department of Life Sciences of the French Energy Atomic Commission (Cyceron, Caen) as a postdoctoral Chemist Engineer. During this period he was introduced to PET radiochemistry for imaging brain receptors. One of his first targets was the preparation and labeling with [11C]KCN of a high affinity ligand to the trypsine plasminogen activator (tPA) which is involved in the processes leading to cerebral ischemia.

At NIMH Dr. Simeon’s major research topic is focused on the development of new ligands and radioligands for imaging the Metabotropic Glutamate Receptor, Subtype 5 (mGluR5) in vivo with PET. He is also engaged in other radioligand developments and some more fundamentally oriented research. His current other topics of research include (1) the radiolabeling of iodonium salts with fluorine-18 under microwave conditions; (2) the synthesis and evaluation of the molecular and biologic properties of ligands for the Peripheral Benzodiazepines Receptors (PBR); (3) the preparation of documentation (e-INDs) to be submitted to FDA for use of new ligands in human studies.