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Transforming the understanding
and treatment of mental illnesses.

Section on Neurobiology of Fear and Anxiety Section on Neurobiology of Fear and Anxiety

Selected Publications

Balderston, N. L., Beydler, E. M., Roberts, C., Deng, Z. D., Radman, T., Lago, T., Luber, B., Lisanby, S. H., Ernst, M., & Grillon, C. (2020). Mechanistic link between right prefrontal cortical activity and anxious arousal revealed using transcranial magnetic stimulation in healthy subjects. Neuropsychopharmacology, 45(4), 694–702. https://doi.org/10.1038/s41386-019-0583-5

Grillon, C., Robinson, O. J., Cornwell, B., & Ernst, M. (2019). Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences. Neuropsychopharmacology, 44(12), 1999–2010. https://doi.org/10.1038/s41386-019-0445-1

Ernst, M., Benson, B., Artiges, E., Gorka, A. X., Lemaitre, H., Lago, T. et al. (2019). Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation. Translational psychiatry, 9(1), 1-14. https://doi.org/10.1038/s41398-019-0433-6

Ernst, M., Gowin, J. L., Gaillard, C., Philips, R. T., & Grillon, C. (2019). Sketching the Power of Machine Learning to Decrypt a Neural Systems Model of Behavior. Brain sciences9(3), 67. https://doi.org/10.3390/brainsci9030067

Torrisi, S., Alvarez, G. M., Gorka, A. X., Fuchs, B., Geraci, M., Grillon, C., & Ernst, M. (2019). Resting-state connectivity of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in clinical anxiety. Journal of psychiatry & neuroscience, 44(5), 313–323. https://doi.org/10.1503/jpn.180150

Torrisi, S., Gorka, A. X., Gonzalez-Castillo, J., O’Connell, K., Balderston, N., Grillon, C., & Ernst, M. (2018). Extended amygdala connectivity changes during sustained shock anticipation. Translational psychiatry8(1), 1-12. https://doi.org/10.1038/s41398-017-0074-6

Gorka, A. X., Fuchs, B., Grillon, C., & Ernst, M. (2018). Impact of induced anxiety on neural responses to monetary incentives. Social cognitive and affective neuroscience13(11), 1111-1119. https://doi.org/10.1093/scan/nsy082

Kundu, P., Benson, B. E., Rosen, D., Frangou, S., Leibenluft, E., Luh, W. M., Bandettini, P. A., Pine, D. S., & Ernst, M. (2018). The Integration of Functional Brain Activity from Adolescence to Adulthood. Journal of neuroscience, 38(14), 3559–3570. https://doi.org/10.1523/JNEUROSCI.1864-17.2018

Ernst M. (2016). Commentary on the special issue on the adolescent brain: A tribute to the adolescent brain. Neuroscience and biobehavioral reviews70, 334–338. https://doi.org/10.1016/j.neubiorev.2016.06.017

Gorka, A. X., Torrisi, S., Shackman, A. J., Grillon, C., & Ernst, M. (2018). Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis. NeuroImage168, 392–402. https://doi.org/10.1016/j.neuroimage.2017.03.007

Grillon, C., Robinson, O. J., O'Connell, K., Davis, A., Alvarez, G., Pine, D. S., & Ernst, M. (2017). Clinical anxiety promotes excessive response inhibition. Psychological medicine, 47(3), 484–494. https://doi.org/10.1017/S0033291716002555

Balderston, N. L., Hsiung, A., Ernst, M., & Grillon, C. (2017). Effect of Threat on Right dlPFC Activity during Behavioral Pattern Separation. The Journal of neuroscience, 37(38), 9160–9171. https://doi.org/10.1523/JNEUROSCI.0717-17.2017

Balderston, N. L., Liu, J., Roberson-Nay, R., Ernst, M., & Grillon, C. (2017). The relationship between dlPFC activity during unpredictable threat and CO2-induced panic symptoms. Translational psychiatry, 7(12), 1-11. https://doi.org/10.1038/s41398-017-0006-5

Balderston, N. L., Hsiung, A., Liu, J., Ernst, M., & Grillon, C. (2017). Reducing State Anxiety Using Working Memory Maintenance. Journal of visualized experiments: JoVE, (125), 55727. https://doi.org/10.3791/55727

Balderston, N. L., Hale, E., Hsiung, A., Torrisi, S., Holroyd, T., Carver, F. W., Coppola, R., Ernst, M., & Grillon, C. (2017). Threat of shock increases excitability and connectivity of the intraparietal sulcus. eLife6, e23608. https://doi.org/10.7554/eLife.23608

Cornwell, B. R., Garrido, M. I., Overstreet, C., Pine, D. S., & Grillon, C. (2017). The Unpredictive Brain Under Threat: A Neurocomputational Account of Anxious Hypervigilance. Biological psychiatry82(6), 447–454. https://doi.org/10.1016/j.biopsych.2017.06.031

Grillon, C., O’Connell, K., Lieberman, L., Alvarez, G., Geraci, M., Pine, D. S., & Ernst, M. (2017). Distinct responses to predictable and unpredictable threat in anxiety pathologies: effect of panic attack. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging2(7), 575-581. https://doi.org/10.1016/j.bpsc.2016.08.005

Torrisi, S., Nord, C. L., Balderston, N. L., Roiser, J. P., Grillon, C., & Ernst, M. (2017). Resting state connectivity of the human habenula at ultra-high field. NeuroImage147, 872–879. https://doi.org/10.1016/j.neuroimage.2016.10.034

Lago, T., Davis, A., Grillon, C., & Ernst, M. (2017). Striatum on the anxiety map: Small detours into adolescence. Brain research1654, 177–184. https://doi.org/10.1016/j.brainres.2016.06.006

Torrisi, S., Robinson, O., O'Connell, K., Davis, A., Balderston, N., Ernst, M., & Grillon, C. (2016). The neural basis of improved cognitive performance by threat of shock. Social cognitive and affective neuroscience11(11), 1677–1686. https://doi.org/10.1093/scan/nsw088

Balderston, N. L., Vytal, K. E., O'Connell, K., Torrisi, S., Letkiewicz, A., Ernst, M., & Grillon, C. (2017). Anxiety Patients Show Reduced Working Memory Related dlPFC Activation During Safety and Threat. Depression and anxiety34(1), 25–36. https://doi.org/10.1002/da.22518

Ernst, M., Torrisi, S., Balderston, N., Grillon, C., & Hale, E. A. (2015). fMRI functional connectivity applied to adolescent neurodevelopment. Annual review of clinical psychology11, 361–377. https://doi.org/10.1146/annurev-clinpsy-032814-112753

Torrisi, S., O'Connell, K., Davis, A., Reynolds, R., Balderston, N., Fudge, J. L., Grillon, C., & Ernst, M. (2015). Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field. Human brain mapping36(10), 4076–4088. https://doi.org/10.1002/hbm.22899

Vytal, K. E., Overstreet, C., Charney, D. R., Robinson, O. J., & Grillon, C. (2014). Sustained anxiety increases amygdala-dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults. Journal of psychiatry & neuroscience: JPN39(5), 321–329. https://doi.org/10.1503/jpn.130145

Robinson, O. J., Vytal, K., Cornwell, B. R., & Grillon, C. (2013). The impact of anxiety upon cognition: perspectives from human threat of shock studies. Frontiers in human neuroscience7, 203. https://doi.org/10.3389/fnhum.2013.00203

Schmitz, A., & Grillon, C. (2012). Assessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test). Nature protocols7(3), 527–532. https://doi.org/10.1038/nprot.2012.001

Alvarez, R. P., Chen, G., Bodurka, J., Kaplan, R., & Grillon, C. (2011). Phasic and sustained fear in humans elicits distinct patterns of brain activity. NeuroImage55(1), 389–400. https://doi.org/10.1016/j.neuroimage.2010.11.057

Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010). Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology, 35(1), 105–135. https://doi.org/10.1038/npp.2009.109