Transforming the understanding
and treatment of mental illnesses.

Transgenic Core Facility Transgenic Core Facility

Menu

Photo Gallery

Click the thumbnail to see a full size version of the picture.

An adult CD-1 B5eGFP mouse
Adult mouse
An adult C57BL6 B5eGFP mouse ubiquitously expresses the green fluorescent protein
Adult mouse
The chimera has produced offspring that carry the agouti coat color gene from the embryonic stem cells.
Chimera mouse produced offspring
A chimeric mouse in which the albino (white skin and pink eye) and brown skin (and black eye) are derived from either the host embryo or embryonic stem cells
Chimeric mouse
This is a map of a vector, or DNA molecule that will be used to make a transgenic mouse.
DNA molecule
Two-cell embryos are aligned in a weak electric field before a stronger pulse forces the two cells to fuse to make a tetrapoloid embryo. These embryos can then be use to make mice that are derived from ES cells alone
Embryo fusion
DNA prepared from mice is screened for the presence of the transgene. The first two lanes are controls, a positive and a negative. The next four lanes show a negative, two positive and another negative mouse sample in order.
Mice DNA
mouse embryo
Mouse embryo
Mouse embryonic stem cells form tightly associated clusters that maintain their totipotency.
Mouse embryonic stem cells
Mouse embryos of different ages that express beta-galatosidase (here indicated by a blue reaction) in a neural stem cells.
Mouse embryos of different ages
Neural stem cells express markers of neural progenitors in culture.
Multi-color neural stem cells
Neural stem cells express markers of neural progenitors in culture.
Neural stem cells
A newborn mouse pup. This is a chimera formed host cells and ES cells that express the green fluorescent protein
Newborn mouse pup
Orange Fluorescent Protein expressed in one of several littermates.
Orange Fluorescent littermates
Orange Fluorescent Protein expressed in C57BL6 mouse pups.
Orange Fluorescent Protein
Tetraploid embryos aggregated with GFP expressing ES cells. The ES cells are contained in the inner cell mass which will give rise to the mouse, the rest of the embryo will form the placenta and extra-embryonic membranes
Tetraploid embryos
transgenic mice agouti coat color
Transgenic mice agouti coat color
To make a transgenic mouse DNA is injected into one of the two pronuclei from a recently fertilized mouse egg.
Transgenic mouse DNA
Transgenic vectors are verified by determining the DNA sequence of the components.
Transgenic vectors

NIMH Information Resource Center

Available in English and español

Phone:  1-866-615-6464
Live Online Chat:  Talk to a representative
Email:  nimhinfo@nih.gov
Hours: 8:30 a.m. – 5 p.m. ET, M-F

Mail:  National Institute of Mental Health
Office of Science Policy, Planning, and Communications
6001 Executive Boulevard, Room 6200, MSC 9663
Bethesda, MD 20892-9663