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An adult CD-1 B5eGFP mouse

Adult mouse

An adult C57BL6 B5eGFP mouse ubiquitously expresses the green fluorescent protein

Adult mouse

The chimera has produced offspring that carry the agouti coat color gene from the embryonic stem cells.

Chimera mouse produced offspring

A chimeric mouse in which the albino (white skin and pink eye) and brown skin (and black eye) are derived from either the host embryo or embryonic stem cells

Chimeric mouse

This is a map of a vector, or DNA molecule that will be used to make a transgenic mouse.

DNA molecule

Two-cell embryos are aligned in a weak electric field before a stronger pulse forces the two cells to fuse to make a tetrapoloid embryo. These embryos can then be use to make mice that are derived from ES cells alone

Embryo fusion

DNA prepared from mice is screened for the presence of the transgene. The first two lanes are controls, a positive and a negative. The next four lanes show a negative, two positive and another negative mouse sample in order.

Mice DNA

mouse embryo

Mouse embryo

Mouse embryonic stem cells form tightly associated clusters that maintain their totipotency.

Mouse embryonic stem cells

Mouse embryos of different ages that express beta-galatosidase (here indicated by a blue reaction) in a neural stem cells.

Mouse embryos of different ages

Neural stem cells express markers of neural progenitors in culture.

Multi-color neural stem cells

Neural stem cells express markers of neural progenitors in culture.

Neural stem cells

A newborn mouse pup. This is a chimera formed host cells and ES cells that express the green fluorescent protein

Newborn mouse pup

Orange Fluorescent Protein expressed in one of several littermates.

Orange Fluorescent littermates

Orange Fluorescent Protein expressed in C57BL6 mouse pups.

Orange Fluorescent Protein

Tetraploid embryos aggregated with GFP expressing ES cells. The ES cells are contained in the inner cell mass which will give rise to the mouse, the rest of the embryo will form the placenta and extra-embryonic membranes

Tetraploid embryos

transgenic mice agouti coat color

Transgenic mice agouti coat color

To make a transgenic mouse DNA is injected into one of the two pronuclei from a recently fertilized mouse egg.

Transgenic mouse DNA

Transgenic vectors are verified by determining the DNA sequence of the components.

Transgenic vectors