Skip to main content

Transforming the understanding
and treatment of mental illnesses.

Transgenic Core Facility Transgenic Core Facility

Publications

SELECTED PUBLICATIONS USING TRANSGENICS CORE RESOURCES  2021-2019

2021

Goertsen, D., Flytzanis, N.C., Goeden, N. et al. AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset. Nat Neurosci (2021). https://doi.org/10.1038/s41593-021-00969-4

Ajiro M, et al. Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nat Comm (2021) https://doi.org/10.1038/s41467-021-24705-5

Briones BA,et al. Adult-born granule cell mossy fibers preferentially target parvalbumin-positive interneurons surrounded by perineuronal nets. Hippocampus 31(4):375-388 (2021) doi: 10.1002/hipo.23296

Wright AM, et al. Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons Expressing Cre recombinase: Sex-Dependent Changes in Neuronal Function and Unaltered Serotonin Signaling. eNeuro, (2021)

Sieb D, et al. Hippocampal neurogenesis promotes preference for future rewards. Mol Psych (2021) https://doi.org/10.1038/s41380-021-01165-3

SIeb D, et al. A role for neurogenesis in probabilistic reward learning. (2020) Behav Neurosci https://doi.org/10.1037/bne0000370

Schoenfeld T, et al. Adult neurogenesis alters response to an aversive distractor in labyrinth maze without affecting special learing or memory. Hippocampus 31(1):102-144 (2021) 10.1002/hipo.23267

2020

Flytzanis N, Goeden N, Goertsen D, Cummins A, Pickel J, Graniaru V. Broad gene expression throughout the mouse and marmoset brain after engineered AAV capsids (2020) BioRXiv https://www.BiorRXiv.org/content/10.1101/2020.06.16.152975v1.

SIeb D, et al. A role for neurogenesis in probabilistic reward learning. (2020) Behav Neurosci https://doi.org/10.1037/bne0000370

Prasad A, et al. An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats. eLife, 9 , pp. e59716 (2020) ISSN: 2050-084X.

McNally JM and Gaven P. Complementary Roles for Ventral Pallidum Cell Types and Their Projections in Relapse. J Neurosci 40 (4), pp. 880–893 (2020) ISSN: 0270-6474.

Strong CE, et al. Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats. Scientific Reports, 10 (1), pp. 19178 (2020) ISBN: 2045-2322.

Báez-Cordero AS, et al. Unbalanced Inhibitory/Excitatory Responses in the Substantia Nigra Pars Reticulata Underlie Cannabinoid-Related Slowness of Movements. J Neurosci 40 (30), pp. 5769,(2020)

Garcia-Keller C, et al. Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons. J Neurosci 40 (44), pp. 8463–8477 (2020) ISSN: 0270-6474.

Pardo-Garcia TR, et al. Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking. J Neurosci 39 (11), pp. 2041–2051, 2019, ISSN: 1529-2401 (Electronic); 0270-6474 (2020)

Strong, CE, et al.Chemogenetic selective manipulation of nucleus accumbens medium spiny neurons bidirectionally controls alcohol intake in male and female rats. Scientific Reports 10 (1), p19178 (2020) ISBN: 2045-2322.

Luo TZ, et al. An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats. eLife 9 , pp. e59716 (2020) ISSN: 2050-084X.

López-Madrona, et al. Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks. eLife 9 pp. e573132 (2020) ISSN: 2050-084X.

Prasada AA, et al. Complementary Roles for Ventral Pallidum Cell Types and Their Projections in Relapse. J Neurosci 40 (4), pp. 880–893 (2020) ISSN: 0270-6474.

2019

Cougnoux A, Drummond RA, Fellmeth M, Navid F, Collar AL, Iben J, Kulkarni AB, Pickel J, Schiffmann R, Wassif CA, Cawley NX, Lionakis MS, Porter FD. Unique molecular signature in mucolipidosis type IV microglia. J Neuroinflammation 16(1):276 (2019) doi: 10.1186/s12974-019-1672-4

Kavarthapu R, Anbazhangan R, Raju R, Morris CT, Pickel J, Dufau ML. Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatatid development during spermatogenesis. Hum Mol Genet 28(15):2561-2572 (2019) doi: 10.1093/hmg/ddz079

Pardo-Garcia TR, Garcia-Keller C, Penaloza T, Richie. CT, Pickel J, Hope BT, Harvey BK, Kalivas PW, Heinsbroek JA. Ventral pallidum is the primary target for accumbens D1 projections driving cocaine seeking. J Neurosci 39(11) 2014-2051 (2019) doi: 10.1523/JNEUROSCI.2822-18.2018

Demaestri C, et al. 22 kHz and 55 kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat. Behav Brain Res 360 pp. 134 - 145, (2019) ISSN: 0166-4328.

Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendrauscolo LF, Harvey BK, Leggio L. Development and initial characterization of a novel ghrelin Receptor CRISPR/Cas9 knockout rat model. Int J Obes (Lond) 43(2):344-354 (2019) doi: 10.1038/s41366-018-0013-5.

Schoenfeld T, et al. New neurons restore structural and behavioral abnormalities in a rat model of PTSD. Hippocampus 29(9):848-861 (2019) DOI: 10.1002/hipo.23087

Weeden CSS, et al. A role for hippocampal adult neurogenesis in shifting attention toward novel stimuli. Behav Brain Res 376:112152 (2019) doi: 10.1016/j.bbr.2019.112152

Bäck S et al. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron 102 (1), pp. 105–119, (2019) ISSN: 1097-4199.

Yu RQ, et al. Adult neurogenesis promotes efficient, nonspecific search strategies in spatial alternation water maze task. Behav Brain Res (2019) doi: 10.1016/j.bbr.2019.112151

OLDER SELECTED PUBLICATIONS USING TRANSGENICS CORE RESOURCES

Pothayee N, Maric D, Sharer K, Tao-Cheng JH, Calac A, Bouraoud N, Pickel J, Dodd S, Koretsky A. Neuronal precursor cells form integrated brain-like tissue when implanted into rat cerebrospinal fluid. Commun Biol 1:114 (2018) doi: 101038/s42003-018-0113-8

Wu Y, Luna MJ, Bonilla LS, Ryba NJP, Pickel J. Characterization of knock in mice at the ROSA26, Tac1 and Piekhg1 loci generated by homologous recombination in oocytes. PLoS One 13(2) (2018) doi: 10.1371/journal.pone.0193128.

Sharpe MJ, Marchant NJ, Whtiaker LR, Richie CT, Zhang YJ, Campbell EJ, Koivula PP, Necarsulmer JC, Mejias-Aponte C, Morales M, Pickel J, Smith JC, Niv Y, Shaham Y, Harvey BK, Shoenbaum G, Lateral hypothalamic GABA-ergic neurons encode reward predication that are relayed to the ventral tegmental area to regulate learning. Curr Biol 27(14):2089-2100 (2017) doi: 10.1016/j.cub.2017.06.024

Richie CT, Whitaker LR, Whitaker KW, Necarsulmer J, Baldwin HA, Zhang Y, Fortuno L, Hinkle JJ, Koivula P, Henderson MJ, Sun W, Wang K, Smith JC, Pickel J, Ji N, Hope BT, Harvey BK. J Neurosci Methods 284:1-4. (2017) doi: 10.1016-/j.jneumeth.2017.03.020

Carr CV, Chen J, Yang F, Ren M, Yuan P, Tian Q, Bebensee A, Zhang GY, Du J, Glinburg P, Xun R, Akhile O, Akuma D, Pickel J, Barrow JC, Papaleo F, Weinberger DR. KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia. Mol Psychiatry 21(11):1517-1526 (2016) doi: 10.1038/mp.2015.219.

Snyder JS, Grigeriet L, Russo A, Seib DR, Brewer M, Pickel J, Cameron HA. A transgenic rat for specifically inhibiting adult neurogenesis. eNeuro 3(13) (2016) doi: 10.1523/ENEURO.0064-16.2016.

Nieto-Estévez V, Oueslati-Morales CO, Li L, Pickel J, Morales AV, Viario-Abejón C. Brain insulin-like growth factor-I directs the transition of stem cells to mature neurons during postnatal / adult hippocampal neurogenesis. Stem Cells 34(8):2194-2209 (2016) doi: 10.1002/stem.2397.

Johnson RF, Via LE, Kumar MR, Cornish JP, Yellayi S, Huzella L, PostnikovaE, Oberlander N, Bartos C, Ork BL, Mazur S, Allan C, Holbrook MR, Solomon J, Johnson JC, Pickel J, Hensley LE, Jahrling PB. Intrathecal exposure of common marmosets to MERS-CoV Jordan ne/2012 or MERS EMC/2012 isolates does not result in lethal disease. Virology 485:422-430 (2015) doi: 10-.1016/j.virol.2015.07.013.

Jinde S, Zsiros V, Jiang Z, Nakao K, Pickel J, Kohno K, Belforte JE, Nakazawa K.
Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation.
Neuron. 2012 Dec20;76(6):1189-200. doi:10.1016/j.neuron.2012.10.036. PubMed PMID: 23259953;PubMed Central PMCID .

Bharti K, Gasper M, Ou J, Brucato M, Clore-Gronenborn K, Pickel J, Arnheiter H.
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.
PLoS Genet. 2012 Jul;8(7):e1002757. doi: 10.1371/journal.pgen.1002757. Epub 2012 Jul 5. PubMed PMID: 22792072; PubMed

Cifani C, Koya E, Navarre BM, Calu DJ, Baumann MH, Marchant NJ, Liu QR, Khuc T, Pickel J, Lupica CR, Shaham Y, Hope BT.
Medial prefrontal cortex neuronal activation and synaptic alterations after stress-induced reinstatement of palatable food seeking: a study using c-fos-GFP transgenic female rats.
J Neurosci. 2012 Jun 20;32(25):8480-90. doi: 10.1523/JNEUROSCI.5895-11.2012. PubMed PMID: 22723688;

Liu J, Zhou L, Xiong K, Godlewski G, Mukhopadhyay B, Tam J, Yin S, Gao P, Shan X, Pickel J, Bataller R, O'Hare J, Scherer T, Buettner C, Kunos G.
Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. Gastroenterology. 2012 May;142(5):1218-1228.e1. doi: 10.1053/j.gastro.2012.01.032. Epub 2012 Jan 31. PubMed PMID: 22307032; PubMed Central PMCID: PMC3482511

Debbache J, Zaidi MR, Davis S, Guo T, Bismuth K, Wang X, Skuntz S, Maric D, Pickel J, Meltzer P, Merlino G, Arnheiter H.
In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor.
Genetics. 2012 May;191(1):133-44. doi: 10.1534/genetics.111.135996. Epub 2012 Feb 23. PubMed PMID: 22367038; PubMed Central PMCID: PMC3338255.

Choi KY, Chang K, Pickel JM, Badger JD 2nd, Roche KW.
Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15219-24. doi: 10.1073/pnas.1107304108. Epub 2011 Sep 6. PubMed PMID: 21896768; PubMed Central PMCID: PMC3174576.

Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA.
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature. 2011 Aug 3;476(7361):458-61. doi: 10.1038/nature10287. PubMed PMID: 21814201; PubMed Central PMCID: PMC3162077.

Tam J, Vemuri VK, Liu J, B√°tkai S, Mukhopadhyay B, Godlewski G, Osei-Hyiaman D, Ohnuma S, Ambudkar SV, Pickel J, Makriyannis A, Kunos G.
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest. 2010 Aug;120(8):2953-66. doi: 10.1172/JCI42551. Epub 2010 Jul 26. Erratum in: J Clin Invest. 2010 Oct 1;120(10):3735. PubMed PMID: 20664173; PubMed Central PMCID: PMC2912197.

Chon-Hwa Tsai Morris. Sheng Y, Gutti R, Li J, Pickel J, Dafau M.
Gonadotropin regulated testicular RNA helicase (GRTH/DDX25) gene: cell specific expression and transcriptional regulation by androgen in transgenic mouse testis.
J Cell Biochem. 2010 Apr 15;109(6):1142-7. doi: 10.1002/jcb.22493. PubMed PMID: 20108248.

Jiang Z, Belforte J, Lu Y, Yabe Y, Pickel J, Smith C, Je H-S, Lu B, Nakazawa K
Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.
J Neurosci. 30(7):2582-2594. (2010)

Shneider NA, Brown MN, Smith CA, Pickel J, Alvarez FJ
Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival.
Neural Dev. 2;4:42. (2009)

Atkin S, Patel S, Kocharyan, A, Holzclaw L, Weerth S, Schram V, Pickel J, Russell J
Transgenic mice expressing a chameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo.
J Neuroci Meth 181: 212-226. (2009)

Micseny MC, Dobrenis K, Stepheny G, Pickel J, Vanier MT, Slaugenhaupt SA, Walkley SU (2009) Neuropathology of the Mcoln1 -/- knockout mouse model of mucolipidosis type IV.
J Neuropath Exp Neurol 68(2): 125-135. (2009)

Fegley DB, Holmes A, Riordan T, Faber CA, Weiss JR, Ma S, Batkai S, Pacher P, Murphy A, Sleeman MW, Usdin TB
Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues
Genes Brain Behav 7(8):933-42. (2008)

Papaleo F, Crawley JN, Song J, Lipska BK, Pickel J, Weinberger ER, Chen J
Genetic dissection of the role of catechol-O-methlytransferase in cognition and stress reactivity in mice.
J Neurosci 28:8709-23. (2008)

Venugopal B, Browning MF, Curcio-Morelli C, Varro A, Michaud N, Wlakley SU, Pickel J, Slaugenhaupt SA
Neruologic, gastric and ophthalmologic pathologies of a murine model of mucolipidosis type IV.
Am J Hum Genet. 81:1070-83. (2007)

Bratiincsak A, Brownstein MJ, Cassiani-Ignoni R, Pastorino S, Szalayova I, Toth ZE, Key S, Nemeth K, Pickel J, Mezey E
CD45-positive blood cells give rise to uterine epithelial cells in mice.
Stem Cells 25:2820-6. (2007)

Hims MM, Shetty RS, Pickel J, Mull J, Leyne M, Liu L, Gusella JF, Slaugenhaupt SA
A humanized IKBKAP transgenic mouse models a tissue-specific human splice defect.
Genomics 90: 389-396. (2007)

Kim T, Zhang C-f, Sun Z, Wu H and Loh P
Chromogranin A deficiency iin transgenic mice leads to aberrant chromoffin granule biogenesis
J Neurosci 25: 6958-6961 (2005)

Orlic D, Kajstua J, Chimeniti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A and Anversa P.
Bone marrow cells regenerate infracted myocardium
Nature 410(6829):701-5 (2001)

Panchision DM, Pickel JM, Studer, L, Lee SH, Turner PA, Hazel TG and McKay RD
Sequential action of BMP receptors control neural precursor cell production and fate.
Genes Dev. 15 (16):2094-110 (2001)
http://www.genesdev.org/cgi/content/full/15/16/2094

Josephson R, Muller T, Pickel J, Okabe S, Reynolds K, Turner PA, Zimmer A and McKay RD
POU transcription factors control expression of CNS stem cell-specific genes
Development 125(16):3087-100 (1998)
http://dev.biologists.org/content/125/16/3087