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Subconstruct: Inhibition and Termination

RDoC Classification

Domain: Sensorimotor Systems > Construct: Motor Actions

Description

Processes involved in the inhibition of motor plans, either before or after an action is initiated, and the sense that a motor plan has been successfully completed. The inhibition sub-construct is commonly operationalized as motor response inhibition and has conceptual overlaps with the Inhibition/Suppression subconstruct of the Cognitive Control construct within the Cognitive Systems domain.

Molecules

Dopamine GABA Norepinephrine

Cells

Intracortical Inhibitory Interneurons Striatal Interneurons

Circuits

Basal Ganglia Cerebellum Dorsolateral Prefrontal Cortex Frontal Eyefields Inferior Frontal Gyrus Inferior Parietal Cortex Lateral Premotor Cortex Medial Prefrontal Cortex Mid-Cingulate Gyrus Posterior Cingulate Gyrus Pre-Supplementary Motor Area Superior Parietal Cortex Supplementary Motor Area

Physiology

Measurements of Cortical Inhibition Oscillatory Rhythms Prepulse Inhibition

Behavior

Activity Level Automatic Obedience Catatonic Immobility Catatonic Rituals Negativism Perseveration Stereotypic behaviors Tics Utilization Behavior

Paradigms

Stop-Signal Reaction Time