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Negative Valence Systems: Potential Threat (Anxiety) - NIMH Research Domain Criteria (RDoC)

Domain: Negative Valence Systems
Construct: Potential Threat ("Anxiety")
————— Units of Analysis —————
Genes Molecules Cells Circuits Physiology Behavior Self-Reports Paradigms


CRF family, cortisol

Pituitary cells

Bed nucleus of stria terminalis

Average cortisol levels, ACTH, potentiated startle



Contextual threat, darkness (in humans), light (in rodents)