HEAL (Helping to End Addiction Long-term) Initiative
In April 2018, NIH launched the HEAL (Helping to End Addiction Long-termSM) Initiative, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. The NIH HEAL Initiative will bolster research across NIH to:
- Improve Treatments for Opioid Misuse and Addiction
More than 2 million Americans have OUD. Millions more misuse opioids, taking opioid medications longer or in higher doses than prescribed. NIH will support research to provide new strategies for the prevention and treatment of opioid misuse and addiction, that will help people with OUD achieve and maintain a meaningful and sustained recovery.
- Enhance Pain Management
More than 25 million Americans suffer from daily chronic pain. NIH will support research to understand how chronic pain develops, making patients susceptible to risks associated with opioid use. NIH will work with partners from the biopharmaceutical industry to develop a data sharing collaborative, new biomarkers for pain, and a clinical trials network for testing new pain therapies. NIH will also enhance the pipeline of treatments for pain and enhance clinical practice for pain management.
NIMH’s Role in the HEAL Initiative
In response to this initiative, the National Institute of Mental Health (NIMH), in partnership with other NIH Institutes, proposes research to adapt collaborative care – a specific service delivery model for treating mental/behavioral health conditions in primary care settings – to meet the needs of individuals with opioid use disorders (OUDs) and co-occurring mental health conditions. Hybrid effectiveness-implementation clinical trials are envisioned to develop, optimize, and test collaborative models that offer Medication-Assisted Treatment (MAT) for OUD alongside indicated treatment for mental health conditions frequently encountered in primary care such as mood and anxiety disorders.
NIMH-Supported NIH HEAL Initiative Projects
NIMH supports the following NIH HEAL-related projects:
- HEAL Initiative: Effectiveness Trials to Optimize, Implement, Scale, and Sustain the Collaborative Care Model for Individuals with Opioid Use Disorders and Mental Health Conditions (U01 Clinical Trial Required) RFA-MH-19-525
- HEAL Initiative: Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 16–30) (UG3/UH3 Clinical Trial Required RFA-DA-19-035
- HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional) RFA-AT-19-006
- HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) RFA-NS-19-021
- HEAL Initiative: Translational Devices to Treat Pain (UG3/UH3 Clinical Trial Optional) RFA-NS-19-016
- HEAL Initiative: Translational Devices to Treat Pain (U44 Clinical Trial Optional) RFA-NS-19-017
- HEAL Initiative: Coordinating Center to Support NIDA Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 16–30) Initiative (U24 Clinical Trial Not Allowed) RFA-DA-19-034
- HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional) RFA-NS-19-018
- HEAL Initiative: Back Pain Consortium (BACPAC) Research Program: Phase 2 Clinical Trials (UG3/UH3 Clinical Trial Required) RFA-AR-19-029
- HEAL Initiative: Back Pain Consortium (BACPAC) Research Program: Mechanistic Research Centers (U19 Clinical Trial Optional) RFA-AR_19-026
- HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Technology Research Sites (UH2/UH3 Clinical Trial Optional) RFA-AR-19-028
- HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center (U24 Clinical Trial Not Allowed) RFA-AR-19-027
- HEAL Initiative Limited Competition: Behavioral Research to Improve MAT: Ancillary Studies to Enhance Behavioral or Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R01 Clinical Trial Optional) RFA-AT-19-007
- HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) (Collaborative R34 Clinical Trial Not Allowed) RFA-DA-19-029
- HEAL Initiative: HEALthy Brain and Child Development Study (HEALthy BCD) (R34 Clinical Trial Not Allowed) RFA-DA-19-036
For additional information on the HEAL Initiative at NIMH, please contact Megan Kinnane at email@example.com. For general inquiries about the HEAL Initiative, please contact HEALquestion@od.nih.gov.
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Last Revised: December 2018