Approved Concepts for Requests for Applications (RFAs), Program Announcements (PAs), and Requests for Proposals (RFPs)
Specific information on each initiative, including receipt date, will be available once the once the RFA, PA, or RFP has been published. This page provides links to recently cleared concepts for solicitations and presents key information, including the objectives and descriptions of potential future solicitations and a direct link to NIMH staff contacts. The NIMH staff contacts can provide additional information on specific concepts, where available and appropriate.
This listing of potential future initiatives is meant to provide the earliest possible alert to potential applicants in order to maximize application preparation time. While the NIMH plans to proceed with these initiatives, their publication and timing is not certain and depends on sufficient funds being available. The titles and brief descriptions are consistent with the information available at the time of concept clearance. The resultant RFAs, PAs, RFPs may differ from the concepts in the final wording of the titles or other aspects.
The National Advisory Mental Health Council also conducts NIMH concept clearances.
Submit comments to Tracy Waldeck at email@example.com.
- Novel Strategies for Targeting HIV-CNS Reservoirs without Reactivation
The goal of this initiative is to stimulate research to identify latently infected cells in the central nervous system (CNS) and developing strategies for viral silencing without pro-viral reactivation.
- NIMH’s New Focus in Clinical Trials
The goal of this effort is to transform the manner in which NIMH solicits and conducts clinical trial research, and to focus applications towards an emphasis on the experimental therapeutics approach to the treatment and prevention of mental disorders in adults and children.
- Research to Improve the Care of Persons at Clinical High Risk for Psychotic Disorders
The goals of this initiative are to (1) test the effectiveness of interventions that target symptomatic and functional difficulties associated with clinical risk states for psychosis; (2) create an evidence base to inform stepped-care models of early psychosis treatment; and, (3) determine the feasibility for implementing such approaches in community treatment settings within the United States.
- Reducing the Duration of Untreated Psychosis in the United States
The goal of this initiative is to support research to identify gaps and bottlenecks in the identification and referral of individuals experiencing first episode psychosis (FEP) in order to develop and test strategies for substantially reducing the duration of untreated psychosis among these individuals.
- Integration and Analysis of Diverse HIV-Associated Data
The aim of this initiative is to maximize and realize the full value of previously collected data to increase our knowledge of etiology and trajectories of HIV-associated consequences on daily functioning and to guide the development of novel, high quality, effective interventions for their prevention and treatment.
- Methodologies and Formative Work for Combination Prevention Approaches
This initiative aims to encourage formative work and methodological innovations to address the complexities of combined HIV prevention intervention approaches.
- Assessing the Role of HIV Stigma in HIV Prevention and Care
This initiative aims to expand the understanding of the role HIV-associated stigma plays in the HIV testing, care, and treatment continuum, and to examine potential effects of interventions on HIV-associated stigma.
- Genomic Risk and Resilience in 22q11 Deletion Syndrome: A Window into the Genetic Architecture of Mental Disorders
The goal of this initiative is to use 22q11 deletion syndrome (DS) as a model to study and discover genetic risk and resilience factors and pathways for neurodevelopmental disorders, including schizophrenia and autism spectrum disorder.
- Advancing Community-level Approaches to Reduce HIV Infection in Highly Impacted Communities
To advance community-level HIV prevention interventions among geographic locations and populations highly impacted by HIV in the United States (US).
- Research to Improve Treatment Engagement for Mental Health Care across Diverse Groups
To fill critical gaps in the treatment engagement (TE) evidence base for people who are members of racial/ethnic minority groups and for people with serious mental illness (SMI), regardless of race/ethnicity; and, to facilitate implementation and uptake of evidence-based TE interventions across diverse groups to increase the public health impact of mental health care.
- Grand Challenges in Global Mental Health: Integrating Mental Health into Chronic Care Provision in Low- and Middle-Income Countries
To promote the establishment of an evidence base on contextually relevant, cost-effective integrated care interventions for the treatment of co-morbid mental and chronic illnesses in resource-poor low- and middle-income countries (LMICs).
- Implementation Science for the Mental Health Gap Action Program
To conduct comparative research on the implementation and scale-up of evidence-based mental health interventions in low- and middle-income settings.
- Study of Health Outcomes in Autistic Children and Their Families
The goal of this initiative is to describe the health and health care trajectories of individuals with autism spectrum disorders (ASD) and their families, and to evaluate the feasibility of using a large population-based database for research on risk factors for ASD.
- Development of a Clinically Useful Classification of Mental Disorders for Global Primary Care
The goal of this initiative is to develop a clinically useful classification of mental disorders to identify people in need of mental health services in primary care settings, particularly in low- and middle-income countries.
- Blueprint Undergraduate Neuroscience Research Training Initiative: Increasing Diversity
The goal of this initiative is to support the development of collaborative undergraduate research education/training programs with the purpose of increasing the pool of students who are well-prepared and motivated to enter Ph.D. programs in the neurosciences. This initiative will target undergraduate students who are from diverse backgrounds (i.e., students from backgrounds historically underrepresented in the biomedical sciences). This initiative will be supported through the NIH Blueprint for Neuroscience Research, consisting of 16 NIH Institutes, Centers, and Offices that collectively support neuroscience research.
- Seeding National Mentoring Networks to Enhance Diversity of the Mental Health Research Workforce
The goal of this initiative is to enable the conceptualization, planning, and piloting of prototypes for national infrastructures to mentor individuals from diverse backgrounds who are conducting research relevant to the mission of the NIMH.
- Identifying Modifiable Risk Factors for Suicidality
This initiative will evaluate selected samples of soldiers across all phases of United States Army Service, both cross-sectionally and longitudinally, to identify modifiable risk factors, mediators, and moderators of suicide-related behaviors, as well as protective factors. The goal of this research is to evaluate multiple determinants of suicide related-events, for the purpose of developing effective strategies for mitigating suicide risk and preventing suicide behaviors.
- Development of Innovative Interventions for Adult Anorexia Nervosa
This initiative would encourage pilot intervention studies to develop novel, innovative treatments for Anorexia Nervosa (AN) in older adolescents and adults.