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and treatment of mental illnesses.

Major Depression

Definitions

Major depression is one of the most common mental disorders in the United States. For some individuals, major depression can result in severe impairments that interfere with or limit one’s ability to carry out major life activities.

Additional information can be found on the NIMH Health Topics page on Depression.

The past year prevalence data presented here for major depressive episode are from the 2019 National Survey on Drug Use and Health (NSDUH). The NSDUH study definition of major depressive episode is based mainly on the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5):

  • A period of at least two weeks when a person experienced a depressed mood or loss of interest or pleasure in daily activities, and had a majority of specified symptoms, such as problems with sleep, eating, energy, concentration, or self-worth.
  • No exclusions were made for major depressive episode symptoms caused by medical illness, substance use disorders, or medication.

Prevalence of Major Depressive Episode Among Adults

  • Figure 1 shows the past year prevalence of major depressive episode among U.S. adults aged 18 or older in 2019.
      • An estimated 19.4 million adults in the United States had at least one major depressive episode. This number represented 7.8% of all U.S. adults.
      • The prevalence of major depressive episode was higher among adult females (9.6%) compared to males (6.0%).
      • The prevalence of adults with a major depressive episode was highest among individuals aged 18-25 (15.2%).
    • The prevalence of major depressive episode was highest among those who report having multiple (two or more) races (13.7%).

Figure 1

Past Year Prevalence of Major Depressive Episode Among U.S. Adults (2017)
Demographic Percent
Overall 7.8
Sex Female 9.6
Male 6.0
Age 18-25 15.2
26-49 8.9
50+ 4.7
Race/Ethnicity Hispanic or Latino* 6.8
White 8.5
Black or African American  6.3
Asian 4.7
NH/OPI 3.5
AI/AN 9.4
2 or More 13.7

*Persons of Hispanic origin may be of any race; all other racial/ethnic groups are non-Hispanic |
NH/OPI = Native Hawaiian / Other Pacific Islander | AI/AN = American Indian / Alaskan Native

Major Depressive Episode with Impairment Among Adults

  • In 2019, an estimated 13.1 million U.S. adults aged 18 or older had at least one major depressive episode with severe impairment in the past year. This number represented 5.3% of all U.S. adults.

Treatment of Major Depressive Episode Among Adults

  • In 2019, an estimated 66.3% U.S. adults aged 18 or older with major depressive episode received treatment in the past year.
  • Among those individuals with major depressive episode with severe impairment, an estimated 72.2% received treatment in the past year.

Prevalence of Major Depressive Episode Among Adolescents

  • Figure 2 shows the past year prevalence of major depressive episode among U.S. adolescents in 2019.
    • An estimated 3.8 million adolescents aged 12 to 17 in the United States had at least one major depressive episode. This number represented 15.7% of the U.S. population aged 12 to 17.
    • The prevalence of major depressive episode was higher among adolescent females (23.0%) compared to males (8.8%).
    • The prevalence of major depressive episode was highest among adolescents reporting two or more races (20.9%).

Figure 2

Persons of Hispanic origin may be of any race; all other racial/ethnic groups are non-Hispanic | AI/AN = American Indian/Alaska Native. Note: Estimates for Native Hawaiian / Other Pacific Islander groups are not reported in the above table due to low precision.
Demographic Percent
Overall 15.7
Sex Female 23.0
Male 8.8
Age 12-13 10.5
14-15 16.4
16-17 20.1
Race/Ethnicity Hispanic* 17.3
White 15.9
Black or African American 11.4
Asian 15.1
AI/AN 12.2
2 or more Races 20.9

*Persons of Hispanic origin may be of any race; all other racial/ethnic groups are non-Hispanic | AI/AN = American Indian/Alaska Native.
Note: Estimates for Native Hawaiian / Other Pacific Islander groups are not reported in the above table due to low precision.

Major Depressive Episode with Impairment Among Adolescents

  • In 2019, an estimated 2.7 million adolescents aged 12 to 17 in the United States had at least one major depressive episode with severe impairment in the past year. This number represented 11.1% of the U.S. population aged 12 to 17.

Treatment of Major Depressive Episode Among Adolescents

  • In 2019, an estimated 43.3% of U.S. adolescents with major depressive episode received treatment in the past year.
  • Among adolescents with major depressive episode with severe impairment, an estimated 49.7% received treatment in the past year.

Data Sources

Statistical Methods and Measurement Caveats

Diagnostic Assessment:

  • For the NSDUH survey — no exclusions were made for major depressive episode symptoms caused by medical illness, substance use disorders, or medication.
  • For the NSDUH survey, methodology developed prior to the 2013 publication of the current DSM-5 was used to facilitate year-to-year comparisons.
  • The adult and adolescent questions were adapted from the depression module in the National Comorbidity Survey Replication (NCS-R). Revisions to the questions in the modules were made primarily to reduce their length and to modify the NCS-R questions, which are interviewer-administered, to the audio computer-assisted self-interviewing (ACASI) format used in NSDUH. In addition, some revisions, based on cognitive testing, were made to improve comprehension. Furthermore, even though titles similar to those used in the NCS-R were used for the NSDUH modules, the results of these items may not be directly comparable. This is mainly due to differing modes of administration in each survey (ACASI in NSDUH vs. computer-assisted personal interviewing in NCS-R), revisions to wording necessary to maintain the logical processes of the ACASI environment, and possible context effects resulting from deleting questions not explicitly pertinent to major depression.
  • Some questions in the adult depression module differ slightly from questions in the adolescent depression module; as such, major depressive episode data for adults aged 18 or older should not be compared to or combined with major depressive episode data for youths aged 12 to 17.
  • The Sheehan Disability Scale (SDS) was used to assess the impact of major depressive episode on a person’s life. The SDS is a brief self-report tool with ratings from 0 to 10 (with 10 being the highest) for the level of impairment caused by the disorder in each of four role domains: home management, work, close relationships with others, and social life. A rating of ≥7 in at least one domain is considered to be severe impairment. Respondents were excluded if SDS role impairment severity was unknown, or if particular activities listed in the SDS were not applicable. For SDS level of impairment, the role domains for adolescents aged 12 to 17 were slightly modified from those for adults to be made age appropriate.

Population:

  • The entirety of NSDUH respondents for the major depressive episode estimates is the civilian, non-institutionalized population aged 12-17 (adolescents) and 18 years old or older (adults) residing within the United States.
  • The survey covers residents of households (persons living in houses/townhouses, apartments, condominiums; civilians living in housing on military bases, etc.) and persons in non-institutional group quarters (e.g., shelters, rooming/boarding houses, college dormitories, migratory workers' camps, and halfway houses).
  • The survey does not cover persons who, for the entire year, had no fixed address (e.g., homeless and/or transient persons not in shelters); were on active military duty; or who resided in institutional group quarters (e.g., correctional facilities, nursing homes, mental institutions, long-term hospitals).
  • Some adults and adolescents in these excluded categories may have had a major depressive episode in the past year, but they are not accounted for in the NSDUH major depressive episode estimates.
  • Sex (i.e., male and female) was recorded by the interviewer.

Interview Response and Completion:

  • In 2019, 35.1% of the selected NSDUH sample did not complete the interview.
  • Reasons for non-response to interviewing include: refusal to participate (23.9%); respondent unavailable or no one at home (6.2%); and other reasons such as physical/mental incompetence or language barriers (5.0%).
  • Adults and adolescents with major depressive episode may disproportionately fall into these non-response categories. While NSDUH weighting includes non-response adjustments to reduce bias, these adjustments may not fully account for differential non-response by mental illness status.

Please see the 2019 National Survey on Drug Use and Health Methodological Summary and Definitions report for further information on how these data were collected and calculated.

Last Updated: October 2021