Armin Raznahan, M.D., Ph.D.Chief
Developmental Neurogenomics Unit
Armin Raznahan, MD, PhD, is a Lasker Clinical Research Scholar and Chief of the Developmental Neurogenomics Unit. His research combines neuroimaging, genomic and bioinformatic techniques to better understand the architecture of human brain development in health, and in neurogenetic disorders that increase risk for psychiatric symptoms. Clinically, Dr. Raznahan works as a Child Psychiatrist within the NIH Clinical Center Psychiatry Consultation Liaison Service. He has a degree in Medicine and a PhD in Biological Psychiatry from King¹s College University London, UK. He has completed residencies in pediatrics and psychiatry, and a specialist fellowship in child and adolescent psychiatry at the Maudsley Hospital, London, UK.
The Developmental Neurogenomics Unit (DNU) is dedicated to better understanding the biology of childhood-onset neuropsychiatric disorders in ways that might ultimately help to improve disease prediction, detection and treatment. Together with our collaborators, we work towards this goal in two mutually-informative ways.
First, we use large-scale longitudinal neuroimaging datasets to study the architecture of brain development in healthy volunteers. By modeling how neuroimaging measures of the human brain vary with age, sex and behavior in health, we hope to advance basic developmental neuroscience while also providing a data-driven way of selecting neuroimaging measures that should be prioritized for study in atypically developing groups.
Second, we use a “genetics-first” strategy to study the relationship between atypical brain development and neuropsychiatric symptoms. This effort involves gathering “deep-phenotypic” data (spanning measures of gene expression, brain structure/function, psychophysiology, cognition and behavior) in diverse genetic disorders which all increase risk for neuropsychiatric impairment. Guided by knowledge of typical development, we harness these clinical data to empirically dissect the diverse biological pathways that can contribute to the emergence of neuropsychiatric syndromes.
Cross-cutting themes of special interest within our Unit include sex-differences, allometry, and structure-function relationships within the central nervous system.
Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies. Raznahan A, Lue Y, Probst F, Greenstein D, Giedd J, Wang C, Lerch J, Swerdloff R . Brain Struct Funct. (2014) PMID: 25146308.
Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development. Raznahan A, Lee NR, Greenstein D, Wallace GL, Blumenthal JD, Clasen LS, Giedd JN. Cereb Cortex. (2014) PMID: 25146371.
Longitudinal four-dimensional mapping of subcortical anatomy in human development. Raznahan A, Shaw PW, Lerch JP, Clasen LS, Greenstein D, Berman R, Pipitone J, Chakravarty MM, Giedd JN. Proc Natl Acad Sci USA . 111:1592–1597 (2014) PMID: 24474784.
Compared to what? Early brain overgrowth in autism and the perils of population norms. Raznahan A, Wallace GL, Antezana L, Greenstein D, Lenroot R, Thurm A, Gozzi M, Spence S, Martin A, Swedo SE, Giedd JN. Biol Psychiatry. 74:563–575 (2013) PMID: 23706681.
Prenatal growth in humans and postnatal brain maturation into late adolescence. Raznahan A, Greenstein D, Lee NR, Clasen LS, Giedd JN. Proc Natl Acad Sci U S A. 109:11366–11371 (2012) PMID: 22689983.
Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling. Raznahan A, Lerch JP, Lee N, Greenstein D, Wallace GL, Stockman M, Clasen L, Shaw PW, Giedd JN. Neuron. 72:873–884 (2011) PMID: 22153381.
How does your cortex grow?. Raznahan A, Shaw P, Lalonde F, Stockman M, Wallace GL, Greenstein D, Clasen L, Gogtay N, Giedd JN. J Neurosci. 31:7174–7177 (2011) PMID: 21562281.
Sex-chromosome dosage effects on gene expression in humans. Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH. Proc Natl Acad Sci U S A. 115(28):7398-7403 PMID: 29946024.
Normative brain size variation and brain shape diversity in humans. Reardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTM, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, Chakravarty MM, Satterthwaite TD, Shinohara RT, Raznahan A. Science. 360(6394):1222-1227 PMID: 29853553.
Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive Variation. Seidlitz J, Váša F, Shinn M, Romero-Garcia R, Whitaker KJ, Vértes PE, Wagstyl K, Kirkpatrick Reardon P, Clasen L, Liu S, Messinger A, Leopold DA, Fonagy P, Dolan RJ, Jones PB, Goodyer IM; NSPN Consortium, Raznahan A, Bullmore ET. Neuron. 97(1):231-247.e7 PMID: 29276055.
Magnuson Clinical Center, Room 4D18, MSC 1367
BETHESDA, MD 20814
Phone: +1 301 435 7927
Fax: +1 301 402 0296