Mark H Histed, Ph.D.Chief
Unit on Neural Computation and Behavior (Histed group)
Dr. Histed received a Ph.D. from the Massachusetts Institute of Technology, where with Earl K. Miller he studied how frontal and basal ganglia neuronal activity underlies complex behaviors. He did postdoctoral work at Harvard and the University of Chicago, with R. Clay Reid and John H.R. Maunsell, studying how the cerebral cortex represents the sensory world and developing psychophysical methods to measure perceptual behavior in rodents. Dr. Histed joined NIMH as an principal investigator in 2016.
A single sensory stimulus or motor action changes the activity of thousands or more neurons in the mammalian cerebral cortex. Dr. Histed’s group uses sensory behavior in the mouse, combined with in vivo electrophysiology, optogenetics, and two-photon imaging, to understand how the brain interprets the activity of many cells --- how the brain decodes neurons’ spikes to make decisions.
Cortical neuronal networks can integrate inputs linearly, independent of synchrony. Histed MH, Maunsell JHR. Proc Natl Acad Sci USA. 2014 Jan 7;111(1):E178-87. PMID: 24367105.
Mouse primary visual cortex is used to detect both orientation and contrast changes. Glickfeld LL*, Histed MH*, Maunsell JHR. J Neurosci. 2013 Dec 11;33(50):19416-22 PMID: 24336708.
Psychophysical measurement of contrast thresholds in the behaving mouse. Histed MH, Carvalho LA, Maunsell JHR. J Neurophysiol. 2012 Feb. 107(3):758-65 PMID: 22049334.
Insights into the cortical mechanisms of behavior from microstimulation experiments. Histed MH, Ni AM, Maunsell JHR. Prog Neurobiol. 2012 Jan 28 PMID: 22307059.
Similarity of visual selectivity among clonally related neurons in visual cortex. Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed MH, Lois C, Ohki K. Neuron. 2012 Jul 12; 75(1):65-72 PMID: 22794261.
Local diversity and fine-scale organization of receptive fields in mouse visual cortex. Bonin V, Histed MH, Yurgenson S, and Reid RC. J Neurosci. 2011 Dec 14;31(50):18506-21 PMID: 22171051.
Direct activation of sparse, distributed sets of cortical neurons with electrical microstimulation. Histed MH, Bonin V, and Reid RC. Neuron. 2009 Aug 27; 63(4): 508-22 PMID: 19709632.
Learning substrates in the primate prefrontal cortex and striatum: sustained activity related to successful actions.. Histed MH*, Pasupathy A*, and Miller EK. Neuron. 2009 Jul 30;63(2):244-53 PMID: 19640482.
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