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Science News from 2023

Image of brain using color to show the strength of electric field generated through MST.
Magnetic Seizure Therapy as Effective as Electroconvulsive Therapy for Treating Depression

This clinical trial found that MST is equally effective at reducing depression symptoms as ECT, but with fewer side effects.

Spatial distribution of diverse cell types in the mouse brain. Here, MERFISH was used to measure 500 genes in the mouse brain to reveal the complex distribution of cell types throughout the brain. Courtesy of Yao/van Velthoven/Zeng, Allen Institute.
Scientists Unveil Complete Cell Map of a Whole Mammalian Brain

For the first time ever, an international team of researchers has created a complete cell atlas of a whole mammalian brain.

Dressed in a white shirt and red tie, Josh Santana smiles with the Boston cityscape behind him.
The Ups and Downs of Bipolar Disorder

75th Anniversary

Josh Santana shares his story of growing up with ADHD and bipolar disorder.

Kristina Saffran sitting on a chair smiling.
Life Beyond Anorexia Nervosa

75th Anniversary

An in-depth look at Kristina Saffran's journey with Anorexia Nervosa.

National Essay Contest for High School Students Ages 16-18. Speaking Up About Mental Health. Cash prizes! Entries due January 16, 2024. A high school student in a wheelchair using her laptop. Three teens collaborating on a writing project.
High School Students Invited to Reflect on Mental Health Stigma in National Essay Contest

The National Institutes of Health is inviting high school students ages 16-18 to participate in an essay contest on the topic of mental health stigma.

An organization chart featuring brightly colored icons of people standing in squares.
NIMH Creates Division of Data Science and Technology

On October 23, the National Institute of Mental Health (NIMH) announced the creation of a new Division of Data Science and Technology (DST).

Photo of a pair of woman’s hands holding another woman’s hand on a table.
Saving Lives Through the Science of Suicide Prevention

75th Anniversary

Evidence-based efforts to improve suicide risk screening, assessment, and intervention are helping to save lives, thanks to research supported by NIMH.

Diverse group of doctors and nurses looking together at a tablet in a doctor's hand.
Emergency Department Intervention Reduces Adult Suicide Risk

Evidence-based practices for suicide prevention effectively reduced suicidal behaviors among adults seen for care in emergency departments.

Scrabble pieces spelling out "Ketamine."
Cracking the Ketamine Code

75th Anniversary

NIMH supported science and NIMH researchers helped pave the way for the development of ketamine—a groundbreaking treatment that has improved the lives of those who are impacted by treatment-resistant depression.

Woman holding a burning cigarette.
Helping People With Serious Mental Illness Quit Smoking

In a study funded by the National Institute of Mental Health and published in JAMA Psychiatry, Gail Daumit, M.D., of Johns Hopkins University, A. Eden Evins, M.D., of Massachusetts General Hospital and Harvard Medical School, and colleagues developed a tobacco smoking cessation intervention for people with serious mental illness.

Illustration of abstract brain on blue background.
Scientists Unveil Detailed Cell Maps of the Human Brain and the Nonhuman Primate Brain

A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain, allowing for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.

NIH Common Fund Community Partnerships to Advance Science for Society (ComPASS) program
NIH Launches Community-Led Research Program to Advance Health Equity

NIH is funding a first-of-its-kind community-led research program to study ways to address the underlying structural factors within communities that affect health, such as access to safe spaces, healthy food, employment opportunities, transportation, and quality health care.

Worried pregnant woman sitting at home with protective face mask, looking through the window and holding stomach.
Combined, High Maternal Stress and Prenatal COVID-19 Infection May Affect Attention Span in Infants

Prenatal COVID-19 infection increased the risk for impaired attention and delayed socioemotional and cognitive functioning among infants of mothers who experienced high psychosocial stress during their pregnancy.

Professional looking young woman standing in a conference room while smiling and holding a tablet, with a group of people working in the background.
RAISE-ing the Standard of Care for Schizophrenia: The Rapid Adoption of Coordinated Specialty Care in the United States

75th Anniversary

The Recovery After an Initial Schizophrenia Episode research initiative, launched by NIMH to test the effectiveness of coordinated specialty care to treat first-episode psychosis, has transformed the mental health landscape in the United States and helped thousands of people with schizophrenia achieve better outcomes.

A headshot of Dr. Patricia A. Areán.
Dr. Patricia A. Areán Named New Director of NIMH’s Division of Services and Intervention Research

Patricia A. Areán, Ph.D., has been selected as the new director of the National Institute of Mental Health’s (NIMH) Division of Services and Intervention Research (DSIR).

Headshot of Dr. Lisa Bowleg.
Dr. Lisa Bowleg Named James S. Jackson Memorial Award Winner

The National Institute of Mental Health (NIMH) has named applied Social Psychologist Lisa Bowleg, Ph.D., M.A., the 2023 James S. Jackson Memorial Award winner.

Swarm of human immunodeficiency virus.
Blocking HIV Enzyme Reduces Infectivity and Slows Viral Rebound

In this NIMH-funded study, researchers developed a compound that blocked an enzyme critical for forming HIV particles, which stopped the virus from correctly forming and becoming infectious.

Emergency department sign at a hospital
Youth Emergency Department Visits for Mental Health Increased During Pandemic

Hospital visits for urgent mental health care increased among children and teens in the second year of the COVID-19 pandemic, according to an NIMH-supported study.

Model showing glycine (teal) docking on the receptor GPR158. The dotted lines show contacts glycine molecule forms with GPR158. Courtesy of the Martemyanov lab, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology.
Researchers Solve the Puzzle of a Brain Receptor’s Activation

Researchers in a NIMH-supported study identified a new receptor for glycine that helps enhance communication between nerve cells in the brain and offers a potential new target for treating mental disorders.

A mother tightly hugging her young daughter.
Mothers' Difficult Childhoods Impact Their Children’s Mental Health

In this NIMH-funded study, researchers examined how trauma gets passed from one generation to the next.

Illustration of communication between neurons.
Newly Discovered Brain Connection Affects Reward Behavior in Mice

NIMH-funded research sheds light on how negative early life experiences may impact how we act in response to rewards, which is often disrupted in people with mental illnesses.

Concept of neurons communicating with an explosion of activity between two neurons.
Researchers Find Order in the Language of the Brain

New research supported by NIMH used mathematical approaches to explain how neurons in the brain communicate over time to support information processing.

Illustration of a group of young people of different genders, races, and ethnicities standing in a row and wearing face masks.
Youth Suicide Rates Increased During the COVID-19 Pandemic

In one of the first studies to examine national youth suicide rates during the COVID-19 pandemic, researchers showed that the pandemic increased youth suicide rates and the impact varied by sex, age, and race and ethnicity.

Portrait of Dr. Susan Daniels
NIMH’s Dr. Susan Daniels Designated National Autism Coordinator

Susan A. Daniels, Ph.D. has been appointed as the HHS National Autism Coordinator and Director of the Office of National Autism Coordination (ONAC).

Pregnant woman holds her baby bump while a therapist in the background takes notes.
Population Study Finds Depression Is Different Before, During, and After Pregnancy

New NIMH-funded research tracked population-level rates of postpartum depression among new mothers before, during, and after pregnancy.

A smiling parent sits in an exam room holding her happy child and talking with a health care provider
Infants’ Health Record Data May Improve Early Autism Screening

Research supported by NIMH suggests that children’s health records may yield some promising insights that could improve the accuracy of early autism screening.

Hands resting on the front of a laptop computer keyboard.
Chatbot Encourages People With Eating Disorders to Seek Care

In a new NIMH-funded study, Ellen Fitzsimmons-Craft, Ph.D., an associate professor of psychiatry at Washington University School of Medicine, and colleagues developed a chatbot to encourage people with eating disorders to connect with care.

Multi-colored brain in space with a dotted background. Courtesy of the Gleeson Lab for Pediatric Brain Disease, University of California San Diego and Rady Children's Institute for Genomic Medicine.
Researchers Unlock Genetic Mutations Contributing to Disorders in the Brain

Researchers identified novel genes with mosaic mutations contributing to treatment-resistant pediatric epilepsy and pointing to specific disrupted pathways in cortical development.

Illustration of white blood cells and red blood cells
HIV Can Persist for Years in Myeloid Cells of People on Antiretroviral Therapy

A subset of white blood cells, known as myeloid cells, can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy, according to findings from a small study supported by the National Institutes of Health.

Notebook with the word “Medicaid” written on the front, surrounded by a pen, notebook, stethoscope, and glasses.
Medicaid Data Show Wide Differences in Mental Health Care in the United States

A new NIMH-supported study revealed differences in rates of mental health care among Medicaid enrollees based on where they live in the United States.

Overhead shot of crowd watching a sports event.
New NIH Study Reveals Shared Genetic Markers Underlying Substance Use Disorders

Analyzing genomic data from more than 1 million people, researchers have identified genes that are commonly inherited across substance use disorders, regardless of the substance being used.

Arrow breaking through wall-like barrier.
Breaking Down Barriers to HIV Medication Access

Researchers investigated whether home delivery of ART for a modest fee could help improve ART access and use, finding it resulted in increased viral suppression in participants compared with clinic-based medication distribution.

Illustration of silhouettes against a cityscape background
Long-acting antiretroviral therapy suppresses HIV among people with unstable housing, mental illnesses, substance use disorder

A long-acting antiretroviral treatment given every four to eight weeks, and delivered with comprehensive support services, suppressed HIV in people who were previously not virologically suppressed.

Toddlers playing with blocks
Attention to Geometric Images May Offer Biomarker for Some Toddlers with Autism

An NIMH-supported study shows that preference for geometric images may be robust enough to serve as a biomarker for identifying some young children with autism.

A headshot of Karen Berman, M.D.
NIMH Researcher Karen Berman Elected as AAAS Fellow

Karen Berman, M.D., a senior investigator at the National Institute of Mental Health (NIMH), has been elected as a 2022 American Association for the Advancement of Science (AAAS) Fellow.

Diverse group of adolescents standing together while wearing face masks.
COVID-19 Pandemic Associated With Worse Mental Health and Accelerated Brain Development in Adolescents

An NIMH-supported study suggests that adolescents living through the COVID-19 pandemic may be experiencing more anxiety and depression symptoms and accelerated brain aging.

A health care provider talking with a patient
Brief Cognitive Training May Extend the Antidepressant Effects of Ketamine

An NIMH-supported study suggests that a brief self-association training program can extend the effects of a single ketamine infusion by shifting people’s negative self-beliefs.

Illustration of multiethnic group of people
NIMH Creates Publicly Accessible Resource With Data From Healthy Volunteers

The NIMH Healthy Research Volunteer Study aims to build a comprehensive, publicly accessible resource with a range of brain and behavioral data from healthy volunteers.