Science News About Brain Anatomy and Physiology

New research supported by NIMH used mathematical approaches to explain how neurons in the brain communicate over time to support information processing.

A subset of white blood cells, known as myeloid cells, can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy, according to findings from a small study supported by the National Institutes of Health.

An NIMH-supported study suggests that adolescents living through the COVID-19 pandemic may be experiencing more anxiety and depression symptoms and accelerated brain aging.

The NIMH Healthy Research Volunteer Study aims to build a comprehensive, publicly accessible resource with a range of brain and behavioral data from healthy volunteers.

Scientists have developed a research method that allows for a much more detailed examination of the brain processes involved in some neurological and mental disorders.

The National Institutes of Health has launched two transformative projects supported by the Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative: The BRAIN Initiative® Cell Atlas Network and the Armamentarium for Precision Brain Cell Access.

A recent NIMH-supported study investigated whether deep brain stimulation could be personalized for individuals with treatment-resistant depression.

The NIH Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative Cell Census Network (BICCN) has unveiled an atlas of cell types and an anatomical neuronal wiring diagram for the mammalian primary motor cortex, derived from detailed studies of mice, monkeys, and humans.

A new NIMH-supported study found that eating disorder behaviors alter the brain’s reward response process and food intake control circuitry, which can reinforce the behaviors.

Researchers in the NIMH Intramural Research Program have developed a new way to measure the degree to which the proportions of an individual person’s brain differ from the proportions typically seen in the broader population. This technique yields new insights into brain development and offers tools for further study.

A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain’s hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies.

A genetic study has identified neuronal abnormalities in the electrical activity of cortical cells derived from people with a rare genetic disorder called 22q11.2 deletion syndrome.

A scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain.

Researchers funded by NIMH have found that astrocytes, a type of brain cell, can harbor HIV and then spread the virus to immune cells that traffic out of the brain and into other organs.

In a study published in 2019 in the journal Nature Neuroscience, researchers funded by the National Institute of Mental Health investigated the neurobiological changes that occur in the brain circuits of mice when contextual fear memories — fear of a place where an aversive event occurred — are formed and extinguished.

An innovative NIMH-funded trial shows that a receptor involved in the brain’s reward system may be a viable target for treating anhedonia (or lack of pleasure), a key symptom of several mood and anxiety disorders.

NIH-funded research uses machine learning algorithm to predict individual response to a commonly-prescribed antidepressant.

NIH-supported study finds that spatial “replay” in neurons may help rats learn how to navigate toward goals.

The NIH has announced its continued support for the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative by funding more than 180 new BRAIN Initiative awards, bringing the total 2019 budget for the program to more than $424 million.

Researchers have uncovered sex-based differences in the development of the hippocampus and amygdala—brain areas that have been implicated in the biology of several mental disorders that impact males and females differently.

On April 11-13, 2019, approximately 1,500 scientists from many disciplines will attend the fifth annual Brain Research through Advancing Innovative Neurotechnologies (BRAIN)® Initiative Investigators Meeting in Washington, DC. This open meeting provides a forum for discussing scientific developments and potential new directions, and to identify areas for collaboration and research coordination.

Researchers have identified changes in brain connectivity and brain activity during rest and reward anticipation in children with anhedonia, a condition where people lose interest and pleasure in activities they used to enjoy.

Researchers have shown that a type of magnetic resonance imaging — called neuromelanin-sensitive MRI (NM-MRI) — is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness.

A new study in rodents has demonstrated, for the first time, that the brain’s cerebellum plays a role in controlling reward and social preference behavior—findings that shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders.