Skip to content

Science News About Depression

Study Reveals Sex-Based Differences in the Development of Brain Hubs Involved in Memory and Emotion

Press Release

Researchers have uncovered sex-based differences in the development of the hippocampus and amygdala—brain areas that have been implicated in the biology of several mental disorders that impact males and females differently.

Read More

Mental Health Research Centers Forge Collaborations – with ALACRITY

Institute Update

Mental health research center directors emerged from a recent meeting with a renewed commitment to help each other achieve their common mission – to transform care of children, adolescents and adults with severe psychiatric disorders.

Read More

Release of “13 Reasons Why” Associated with Increase in Youth Suicide Rates

Press Release

A study conducted by researchers at several universities, hospitals, and the National Institute of Mental Health (NIMH) found that the Netflix show “13 Reasons Why” was associated with a 28.9% increase in suicide rates among U.S. youth ages 10-17 in the month (April 2017) following the shows release, after accounting for ongoing trends in suicide rates.

Read More

Nationwide Essay Contest Challenges High Schoolers to be Frank About Mental Health

Press Release

The National Institutes of Health invites students ages 16 to 18 years old to participate in the “Speaking Up About Mental Health!” essay contest to explore ways to address the stigma and social barriers that adolescents from racial and ethnic minority populations may face when seeking mental health treatment.

Read More

Ketamine Reverses Neural Changes Underlying Depression-Related Behaviors in Mice

Press Release

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice — findings that may help researchers develop interventions that promote lasting remission of depression in humans.

Read More

Bench-to-Bedside: NIMH Research Leading to Brexanolone, First-Ever Drug Specifically for Postpartum Depression

Press Release

FDA approval of the postpartum depression treatment brexanolone represents the final phase of a bench-to-bedside journey for this drug — a journey that began in the NIMH Intramural Research Program. NIMH experts are available to provide information on postpartum depression and the importance of, and the science underlying, this new drug.

Read More

NIH Study Reveals Differences in Brain Activity in Children with Anhedonia

Press Release

Researchers have identified changes in brain connectivity and brain activity during rest and reward anticipation in children with anhedonia, a condition where people lose interest and pleasure in activities they used to enjoy.

Read More

NIH Study Shows Many Preteens Screen Positive for Suicide Risk During ER Visits

Press Release

A research team found nearly one-third of youth ages 10 to 12 years screened positive for suicide risk in emergency department settings, including those seeking help for physical concerns only.

Read More

Dynamic Associations Among Motor Activity, Sleep, Energy, and Mood Could Suggest New Focus for Depression Treatment

Science Update

A new study looking at interactions among sleep, energy, activity level, and mood suggests that instability in activity and sleep systems could lead to mood changes. The findings suggest new targets for depression treatment.

Read More

Intervention Shows Promise for Treating Depression in Preschool-Aged Children

Press Release

Researchers funded by the National Institutes of Health have shown that a therapy-based treatment for disruptive behavioral disorders can be adapted and used as an effective treatment option for early childhood depression.

Read More

NIMH to Host Twitter Chat on Teen Depression

Institute Update

On May 3, 2018, join NIMH for a Twitter chat on teen depression with experts Dr. Argyris Stringaris and Dr. Ken Towbin.

Read More

Suspect Molecules Overlap in Autism, Schizophrenia, Bipolar Disorder

Science Update

Depression, schizophrenia and autism spectrum disorder share some of the same patterns of suspect gene expression – molecular signatures.

Read More

NIMH Twitter Chat on Seasonal Affective Disorder

Science Update

On February 20, 2018, join NIMH for a Twitter chat on Seasonal Affective Disorder with expert Dr. Matthew Rudorfer.

Read More

Brain’s Alertness Circuitry Conserved Through Evolution

Press Release

Using a molecular method likely to become widely adopted by the field, researchers have discovered brain circuitry essential for alertness – and for brain states more generally.

Read More

Depression’s “Transcriptional Signatures” Differ in Men vs. Women

Science Update

Brain gene expression associated with depression differed markedly between men and women. Such divergent “transcriptional signatures” may signal divergent underlying illness processes requiring sex-specific treatments.

Read More

Webinar: RDoC - Fear & Anxiety: From Mechanisms to Implementation

Institute Update

This November 2016 RDoC webinar highlights the role of fear and anxiety in disorders such as phobias and depression.

Read More

Pediatrics-based Brief Therapy Outdoes Referral for Youths with Anxiety and Depression

Science Update

A streamlined behavioral therapy delivered in a pediatrics practice offered much greater benefit to youth with anxiety and depression than a more standard referral to mental health care with follow-up in a clinical trial comparing the two approaches.

Read More

NIMH Grantee Wins One of Science’s Most Coveted Prizes

Science Update

NIMH grantee Karl Deisseroth, M.D., Ph.D., of Stanford University, has been awarded one of science’s most generous prizes. A German foundation presented the inventor of technologies that are transforming neuroscience with its 4 million euros Fresenius Prize.

Read More

Estrogen Alters Memory Circuit Function in Women with Gene Variant

Science Update

Brain scans reveal that fluctuations in estrogen can trigger atypical functioning in a key brain memory circuit in women with a common version of a gene. Since working memory function is often disturbed in mental disorders, such gene-hormone interactions are suspect mechanisms that may confer risk.

Read More

Tapping Crowd-Sourced Data Unearths a Trove of Depression Genes

Press Release

Scientists have discovered 15 genome sites – the first ever – linked to depression in people of European ancestry. But – in a twist – the researchers didn’t have to sequence anyone’s genes! Instead, they analyzed data already shared by people who had purchased their own genetic profiles via an online service and elected to participate in its research option.

Read More

Electroconvulsive Therapy Lifts Depression, Sustains Remission in Older Adults

Science Update

An individualized program of follow-up treatment with electroconvulsive therapy (ECT) combined with an antidepressant was effective in preventing relapse in patients 60 years and older who had had a successful initial course of treatment for severe depression.

Read More

Ketamine Lifts Depression via a Byproduct of its Metabolism

Press Release

A chemical byproduct, or metabolite, created as the body breaks down likely holds the secret to its rapid antidepressant action .

Read More

Facebook Q&A on Electroconvulsive Therapy

Science Update

On March 17, 2016, NIMH hosts a Facebook Q&A on electroconvulsive therapy with expert Dr. Sarah Lisanby.

Read More

A BRIGHT Technological Future for Mental Health Trials

Science Update

Is mobile mental health research the next frontier for smartphones? Based on Dr. Patricia Areán’s pioneering BRIGHTEN study, research via smartphone app is already a reality.

Read More

Webinar Series – Office for Research on Disparities and Global Mental Health

Science Update

View the archived webinars with NIMH experts and grantees, which focus on training, research, and methodology

Read More

NIH Joins with Women’s Organization to Debut Postpartum Depression Video

Science Update

A new video about postpartum depression marks the launch of a mental health education collaboration by two NIH Institutes and one of the nation’s largest African-American women’s organizations.

Read More

Disorders Share Risk Gene Pathways for Immune, Epigenetic Regulation

Science Update

Risk genes for different mental disorders work through same pathways

Read More

Rapid Agent Restores Pleasure-seeking Ahead of Other Antidepressant Action

Press Release

A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of – and ahead of – its other antidepressant effects.

Read More

NIMH Twitter Chat on Depression and the Development of Novel Medications

Science Update

NIMH Twitter Chat on Depression and the Development of Novel Medications

Read More

NIMH Twitter Chat on Premenstrual Dysphoric Disorder

Science Update

NIMH Twitter Chat on Premenstrual Dysphoric Disorder

Read More

NIMH Twitter Chat on Men and Depression

Science Update

NIMH Twitter Chat on Men and Depression

Read More

NIMH Twitter Chat on Postpartum Depression

Science Update

NIMH Twitter Chat on Postpartum Depression

Read More

Jump-starting Natural Resilience Reverses Stress Susceptibility

Press Release

Scientists have traced vulnerability to depression-like behaviors to out-of-balance neuronal electrical activity and made mice resilient by reversing it.

Read More

Girls Thrive Emotionally, Boys Falter After Move to Better Neighborhood

Science Update

Girls in public housing benefited emotionally from a move to a better neighborhood while boys fared worse than if they’d stayed in the poor neighborhood. Rates of depression and conduct disorder markedly increased in boys and decreased in girls. Boys also experienced significantly increased rates of post-traumatic stress disorder (PTSD), complicating housing policy decision-making.

Read More