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Science News About Depression

Tapping Crowd-Sourced Data Unearths a Trove of Depression Genes

Press Release

Scientists have discovered 15 genome sites – the first ever – linked to depression in people of European ancestry. But – in a twist – the researchers didn’t have to sequence anyone’s genes! Instead, they analyzed data already shared by people who had purchased their own genetic profiles via an online service and elected to participate in its research option.

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Electroconvulsive Therapy Lifts Depression, Sustains Remission in Older Adults

Science Update

An individualized program of follow-up treatment with electroconvulsive therapy (ECT) combined with an antidepressant was effective in preventing relapse in patients 60 years and older who had had a successful initial course of treatment for severe depression.

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Ketamine Lifts Depression via a Byproduct of its Metabolism

Press Release

A chemical byproduct, or metabolite, created as the body breaks down likely holds the secret to its rapid antidepressant action .

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Facebook Q&A on Electroconvulsive Therapy

Science Update

On March 17, 2016, NIMH hosts a Facebook Q&A on electroconvulsive therapy with expert Dr. Sarah Lisanby.

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A BRIGHT Technological Future for Mental Health Trials

Science Update

Is mobile mental health research the next frontier for smartphones? Based on Dr. Patricia Areán’s pioneering BRIGHTEN study, research via smartphone app is already a reality.

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Webinar Series – Office for Research on Disparities and Global Mental Health

Science Update

View the archived webinars with NIMH experts and grantees, which focus on training, research, and methodology

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NIH Joins with Women’s Organization to Debut Postpartum Depression Video

Science Update

A new video about postpartum depression marks the launch of a mental health education collaboration by two NIH Institutes and one of the nation’s largest African-American women’s organizations.

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Disorders Share Risk Gene Pathways for Immune, Epigenetic Regulation

Science Update

Risk genes for different mental disorders work through same pathways

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Rapid Agent Restores Pleasure-seeking Ahead of Other Antidepressant Action

Press Release

A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of – and ahead of – its other antidepressant effects.

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NIMH Twitter Chat on Depression and the Development of Novel Medications

Science Update

NIMH Twitter Chat on Depression and the Development of Novel Medications

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NIMH Twitter Chat on Premenstrual Dysphoric Disorder

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NIMH Twitter Chat on Premenstrual Dysphoric Disorder

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NIMH Twitter Chat on Men and Depression

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NIMH Twitter Chat on Men and Depression

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NIMH Twitter Chat on Postpartum Depression

Science Update

NIMH Twitter Chat on Postpartum Depression

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Jump-starting Natural Resilience Reverses Stress Susceptibility

Press Release

Scientists have traced vulnerability to depression-like behaviors to out-of-balance neuronal electrical activity and made mice resilient by reversing it.

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Girls Thrive Emotionally, Boys Falter After Move to Better Neighborhood

Science Update

Girls in public housing benefited emotionally from a move to a better neighborhood while boys fared worse than if they’d stayed in the poor neighborhood. Rates of depression and conduct disorder markedly increased in boys and decreased in girls. Boys also experienced significantly increased rates of post-traumatic stress disorder (PTSD), complicating housing policy decision-making.

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NIMH Twitter Chat on Depression and Older Adults

Science Update

Join NIMH’s Jovier Evans, Ph.D., Chief of the Geriatric Translational Neuroscience Program, for a Twitter Chat on depression and older adults.

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NeuroBioBank Gives Researchers One-stop Access to Post-mortem Brains

Press Release

The NIH NeuroBioBank provides researchers with one-stop access to post-mortem brains.

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New Data Reveal Extent of Genetic Overlap Between Major Mental Disorders

Press Release

The largest genome-wide study of its kind has determined how much five major mental illnesses are traceable to the same common inherited genetic variations.

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Webinar on Ketamine and Next Generation Therapies Featuring NIMH’s Carlos A. Zarate, M.D.

Science Update

On August 13, 2013, Carlos A. Zarate, M.D., from the National Institute of Mental Health will give a live presentation titled “Ketamine & Next Generation Therapies,” where he will discuss his research on novel medications for treatment-resistant depression and bipolar disorder at the Brain and Behavior Research Foundation.

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Scan Predicts Whether Therapy or Meds Will Best Lift Depression

Press Release

Pre-treatment scans of brain activity predicted whether depressed patients would best achieve remission with an antidepressant medication or psychotherapy, in a study that may help mental health treatment decision-making move beyond trial-and-error. The study sought to identify a biomarker that could predict which type of treatment a patient would benefit from based on the state of his or her brain.

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Bullying Exerts Psychiatric Effects Into Adulthood

Science Update

Once considered a childhood rite of passage, bullying lingers well into adulthood. Bullies and victims alike are at risk for psychiatric problems such as anxiety, depression, substance abuse, and suicide when they become adults, reported a study partially funded by the National Institute of Mental Health (NIMH) that was published in the April issue of JAMA Psychiatry.

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Ketamine Cousin Rapidly Lifts Depression Without Side Effects

Science Update

NMDA or glutamate receptor modulators as antidepressants have come of age. Human clinical studies demonstrated that ketamine can ward off depressive symptoms within 2 hours of administration and last for several days. Yet serious side effects are attached to this drug, including excessive sleepiness, hallucinations, and substance abuse behavior.

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NIH Study Shows People with Serious Mental Illnesses Can Lose Weight

Press Release

Losing weight is challenging for everyone. It can be particularly difficult for someone with a serious mental illness. An NIMH-funded clinical study proves that a modified diet and exercise program can work for people with serious mental illnesses. Participants lost 7 pounds more than controls—and continued to lose weight.

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Five Major Mental Disorders Share Genetic Roots

Science Update

Five major mental disorders share some of the same genetic risk factors, the largest genome-wide study of its kind has found.

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Imaging Biomarker Predicts Response to Rapid Antidepressant

Press Release

A boost of activity in visual cortex at the back of the brain, triggered by the processing of emotional information, predicted depressed patients’ responses to a rapid-acting antidepressant.

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Stress-Resilience/Susceptibility Traced to Neurons in Reward Circuit

Press Release

Researchers, for the first time, have instantly switched depression-like states on-and-off in mice by tweaking the firing pattern of neurons in the brain’s reward circuit.

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Experimental Agent Briefly Eases Depression Rapidly in Test

Press Release

Ketamine-like agent lifts depression briefly in treatment-resistant patients, with few side effects.

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Genetic Switch Involved in Depression

Science Update

Researchers have discovered a gene regulator that is over-expressed in brains of both depressed patients and rats that show depression-like behaviors. Boosting expression of the regulator, Gata1, decreased expression of genes that code for the connections between neurons in rats’ thinking and feeling circuitry, as well as the number of such synapses.

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Brain Signal ID’s Responders to Fast-Acting Antidepressant

Press Release

Biomarkers identified in research on a fast-acting antidepressant can signal who will respond to the medication and are providing clues to how it works to lift depression.

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Pattern Recognition Technology May Help Predict Future Mental Illness in Teens

Science Update

Computer programs that automatically spot patterns in data may help predict a person’s risk for future mental disorders.

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Ethnic Disparities Persist in Depression Diagnosis and Treatment Among Older Americans

Science Update

Older racial and ethnic minorities living in the community are less likely to be diagnosed with depression than their white counterparts, but are also less likely to get treated, according to a recent NIMH-funded analysis published online ahead of print December 15, 2011, in the American Journal of Public Health.

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