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Principal Investigator

Alex Martin

Alex Martin, Ph.D.

Biography

Dr. Martin received his B.A. from the City College of New York and his Ph.D. from the City University of New York. He did his post-doctoral work at the National Institute of Neurological Disorders and Stroke on the breakdown of language and memory processes in Alzheimer's disease. In 1985 he joined the faculty of the Uniformed Services University of the Health Sciences where he studied cognitive dysfunction associated with HIV infection. In 1990 he moved to the NIMH where he continued his work on cognitive abnormalities in neurological and neuropsychiatric disorders. In 1997 Dr. Martin became the Chief of the Cognitive Neuropsychology Section, Laboratory of Brain and Cognition. Dr. Martin is an elected Fellow of the American Association for the Advancement of Science, the American Psychological Society, and the American Psychological Association.

Research Interests

Our goal is to elucidate the neural circuitry associated with specific perceptual, memory, and social functions.  Functional brain imaging technologies - functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) - are used to evaluate these functions in typically developing individuals and patients with neurological and neuropsychiatric disorders.  A major focus of our research is on semantic memory, the part of long-term memory composed of general information, such as facts, ideas, and the meaning of objects and words. We are particularly interested in characterizing the neural circuits mediating object recognition and how this circuitry is modified by experience and learning. We are also interested in understanding how abstract forms of knowledge, such as information about social interactions, are represented in autism spectrum disorders and related conditions.

Selected Publications

Gotts SJ, Simmons WK, Milbury LA, Wallace GL, Cox RW, Martin A (2012) Fractionation of social brain circuits in autism spectrum disorders. Brain 135:2711-25. [Pubmed Link]

Simmons WK, Rapuano KM, Kallman SJ, Ingeholm JE, Miller B, Gotts SJ, Avery JA, Hall KD, Martin A (2013). Category-specific integration of homeostatic signals in caudal but not rostral human insula. Nat Neurosci 16, 1551-2. [Pubmed Link]

Gotts SJ, Jo HJ, Wallace GL, Saad ZS, Cox RW, Martin A (2013) Two distinct forms of functional lateralization in the human brain. Proc Natl Acad Sci U S A 110:E3435-44. [Pubmed Link]

Martin A (2016) GRAPES-Grounding representations in action, perception, and emotion systems: How object properties and categories are represented in the human brain. Psychon Bull Rev 23:979-90. [Pubmed Link]

Plitt M, Barnes KA, Wallace GL, Kenworthy L, Martin A (2015) Resting-state functional connectivity predicts longitudinal change in autistic traits and adaptive functioning in autism. Proc Natl Acad Sci U S A 112:E6699-706. [Pubmed Link]


Magnuson Clinical Center, Room 4C103, MSC 1366
BETHESDA, MD 20814

Phone: +1 301 435 4926
Fax: +1 301 402 0921

alexmartin@mail.nih.gov