Lasker Clinical Research Scholar
Armin Raznahan, M.D., Ph.D.
Armin Raznahan, MD, PhD, is a Lasker Clinical Research Scholar and Chief of the Developmental Neurogenomics Unit. His research combines neuroimaging, genomic and bioinformatic techniques to better understand the architecture of human brain development in health, and in neurogenetic disorders that increase risk for psychiatric symptoms. Clinically, Dr. Raznahan has a degree in Medicine and a PhD in Biological Psychiatry from King’s College University London, UK. He has completed residencies in pediatrics and psychiatry, and a specialist fellowship in child and adolescent psychiatry at the Maudsley Hospital, London, UK. Dr. Raznahan is a member of the Royal College of Pediatrics and Child Health, and the Royal College of Psychiatrists in the U.K. He is also an elected member of the American College of Neuropsychopharmacology. Dr. Raznahan recently received the NIMH Director’s Award for Outstanding Mentorship, and has also been the recipient of awards from the American Psychopathological Association and the International Society for Autism Research.
The Developmental Neurogenomics Unit (DNU) is dedicated to better understanding the biology of childhood-onset neuropsychiatric disorders in ways that might ultimately help to improve disease prediction, detection and treatment. Together with our collaborators, we work towards this goal in two mutually-informative ways.
First, we use large-scale longitudinal neuroimaging datasets to study the architecture of brain development in healthy volunteers. By modeling how neuroimaging measures of the human brain vary with age, sex and behavior in health, we hope to advance basic developmental neuroscience while also providing a data-driven way of selecting neuroimaging measures that should be prioritized for study in atypically developing groups.
Second, we use a “genetics-first” strategy to study the relationship between atypical brain development and neuropsychiatric symptoms. This effort involves gathering “deep-phenotypic” data (spanning measures of gene expression, brain structure/function, psychophysiology, cognition and behavior) in diverse genetic disorders which all increase risk for neuropsychiatric impairment. Guided by knowledge of typical development, we harness these clinical data to empirically dissect the diverse biological pathways that can contribute to the emergence of neuropsychiatric syndromes.
Cross-cutting themes of special interest within our Unit include sex-differences, allometry, and structure-function relationships within the central nervous system.
Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH (2018). Sex-chromosome dosage effects on gene expression in humans. Proc Natl Acad Sci U S A 115, 7398-7403. https://doi.org/10.1073/pnas.1802889115. [Pubmed Link]
Reardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTM, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, Chakravarty MM, Satterthwaite TD, Shinohara RT, Raznahan A (2018). Normative brain size variation and brain shape diversity in humans. Science 360, 1222-1227. https://doi.org/10.1126/science.aar2578. [Pubmed Link]
Seidlitz J, VÃ¡Å¡a F, Shinn M, Romero-Garcia R, Whitaker KJ, VÃ©rtes PE, Wagstyl K, Kirkpatrick Reardon P, Clasen L, Liu S, Messinger A, Leopold DA, Fonagy P, Dolan RJ, Jones PB, Goodyer IM, NSPN Consortium, Raznahan A, Bullmore ET (2018). Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive Variation. Neuron 97, 231-247.e7. https://doi.org/10.1016/j.neuron.2017.11.039. [Pubmed Link]
Mankiw C, Park MTM, Reardon PK, Fish AM, Clasen LS, Greenstein D, Giedd JN, Blumenthal JD, Lerch JP, Chakravarty MM, Raznahan A (2017). Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization. J Neurosci 37, 5221-5231. https://doi.org/10.1523/JNEUROSCI.2158-16.2017. [Pubmed Link]
Raznahan A, Lue Y, Probst F, Greenstein D, Giedd J, Wang C, Lerch J, Swerdloff R (2015). Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies. Brain Struct Funct 220, 3581-93. https://doi.org/10.1007/s00429-014-0875-9. [Pubmed Link]
Magnuson Clinical Center, Room 4D18, MSC 1367
BETHESDA, MD 20814
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