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Principal Investigator

Armin Raznahan, MD, PhD

Armin Raznahan, M.D., Ph.D.

Chief
Developmental Neurogenomics Unit

Biography

Armin Raznahan, MD, PhD, is a Lasker Clinical Research Scholar and Chief of the Developmental Neurogenomics Unit. His research combines neuroimaging, genomic and bioinformatic techniques to better understand the architecture of human brain development in health, and in neurogenetic disorders that increase risk for psychiatric symptoms. Clinically, Dr. Raznahan has a degree in Medicine and a PhD in Biological Psychiatry from King’s College University London, UK. He has completed residencies in pediatrics and psychiatry, and a specialist fellowship in child and adolescent psychiatry at the Maudsley Hospital, London, UK. Dr. Raznahan is a member of the Royal College of Pediatrics and Child Health, and the Royal College of Psychiatrists in the U.K. He is also an elected member of the American College of Neuropsychopharmacology. Dr. Raznahan recently received the NIMH Director’s Award for Outstanding Mentorship, and has also been the recipient of awards from the American Psychopathological Association and the International Society for Autism Research.

Research Interests

The Developmental Neurogenomics Unit (DNU) is dedicated to better understanding the biology of childhood-onset neuropsychiatric disorders in ways that might ultimately help to improve disease prediction, detection and treatment. Together with our collaborators, we work towards this goal in two mutually-informative ways.

First, we use large-scale longitudinal neuroimaging datasets to study the architecture of brain development in healthy volunteers. By modeling how neuroimaging measures of the human brain vary with age, sex and behavior in health, we hope to advance basic developmental neuroscience while also providing a data-driven way of selecting neuroimaging measures that should be prioritized for study in atypically developing groups.

Second, we use a “genetics-first” strategy to study the relationship between atypical brain development and neuropsychiatric symptoms. This effort involves gathering “deep-phenotypic” data (spanning measures of gene expression, brain structure/function, psychophysiology, cognition and behavior) in diverse genetic disorders which all increase risk for neuropsychiatric impairment. Guided by knowledge of typical development, we harness these clinical data to empirically dissect the diverse biological pathways that can contribute to the emergence of neuropsychiatric syndromes.

Cross-cutting themes of special interest within our Unit include sex-differences, allometry, and structure-function relationships within the central nervous system.

Selected Publications

A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Area in Youth. Schmitt, J.E., Neale, M.C., Clasen, L.S., Liu, S., Seidlitz, J., Pritikin, J.N., Chu, A., Wallace, G.L., Lee, N.R., Giedd, J.N., Raznahan, A., 2019a. J. Neurosci. 39, 3028–3040. PMID: 30833512.

Genetics-First Approaches in Biological Psychiatry. Raznahan, A., 2018. Biol. Psychiatry. PMID: 30071946.

Studying neuroanatomy using MRI. Lerch, J.P., van der Kouwe, A.J.W., Raznahan, A., Paus, T., Johansen-Berg, H., Miller, K.L., Smith, S.M., Fischl, B., Sotiropoulos, S.N., 2017. Nat. Neurosci. 20, 314–326. PMID: 28230838.

Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization. Mankiw, C., Park, M.T.M., Reardon, P.K., Fish, A.M., Clasen, L.S., Greenstein, D., Giedd, J.N., Blumenthal, J.D., Lerch, J.P., Chakravarty, M.M., Raznahan, A., 2017. J. Neurosci. 37, 5221–5231. PMID: 28314818.

Influences of Brain Size, Sex, and Sex Chromosome Complement on the Architecture of Human Cortical Folding. Fish AM, Cachia A, Fischer C, Mankiw C, Reardon PK, Clasen LS, Blumenthal JD, Greenstein D, Giedd JN, Mangin JF, Raznahan A. Cereb Cortex. 2017 Dec 1;27(12):5557-5567. PMID: 27799275.

Longitudinally Mapping Childhood Socioeconomic Status Associations with Cortical and Subcortical Morphology. McDermott CL, Seidlitz J, Nadig A, Liu S, Clasen LS, Blumenthal JD, Reardon PK, Lalonde F, Greenstein D, Patel R, Chakravarty MM, Lerch JP, Raznahan A.. J Neurosci. 2019 Feb 20;39(8):1365-1373. PMID: 30587541.

Carriage of Supernumerary Sex Chromosomes Decreases the Volume and Alters the Shape of Limbic Structures. Nadig A, Reardon PK, Seidlitz J, McDermott CL, Blumenthal JD, Clasen LS, Lalonde F, Lerch JP, Chakravarty MM, Raznahan A. eNeuro. 2018 Nov 29;5(5). pii: ENEURO.0265-18.2018. PMID: 30713992.

Characterization of autism spectrum disorder and neurodevelopmental profiles in youth with XYY syndrome. Joseph L, Farmer C, Chlebowski C, Henry L, Fish A, Mankiw C, Xenophontos A, Clasen L, Sauls B, Seidlitz J, Blumenthal J, Torres E, Thurm A, Raznahan A. J Neurodev Disord. 2018 Oct 22;10(1):30. PMID: 30348076.

On testing for spatial correspondence between maps of human brain structure and function. Alexander-Bloch AF, Shou H, Liu S, Satterthwaite TD, Glahn DC, Shinohara RT, Vandekar SN, Raznahan A. Neuroimage. 2018 Sep;178:540-551. PMID: 29860082.

Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies. Raznahan A, Lue Y, Probst F, Greenstein D, Giedd J, Wang C, Lerch J, Swerdloff R. Brain Struct Funct. (2014) PMID: 25146308.

Globally Divergent but Locally Convergent X- and Y-Chromosome Influences on Cortical Development. Raznahan A, Lee NR, Greenstein D, Wallace GL, Blumenthal JD, Clasen LS, Giedd JN. Cereb Cortex. (2014) PMID: 25146371.

Longitudinal four-dimensional mapping of subcortical anatomy in human development. Raznahan A, Shaw PW, Lerch JP, Clasen LS, Greenstein D, Berman R, Pipitone J, Chakravarty MM, Giedd JN. Proc Natl Acad Sci. 111:1592–1597 (2014) PMID: 24474784.

Compared to what? Early brain overgrowth in autism and the perils of population norms. Raznahan A, Wallace GL, Antezana L, Greenstein D, Lenroot R, Thurm A, Gozzi M, Spence S, Martin A, Swedo SE, Giedd JN. Biol Psychiatry. 74:563–575 (2013) PMID: 23706681.

Prenatal growth in humans and postnatal brain maturation into late adolescence. Raznahan A, Greenstein D, Lee NR, Clasen LS, Giedd JN. Proc Natl Acad Sci U S A. 109:11366–11371 (2012) PMID: 22689983.

Patterns of coordinated anatomical change in human cortical development: a longitudinal neuroimaging study of maturational coupling. Raznahan A, Lerch JP, Lee N, Greenstein D, Wallace GL, Stockman M, Clasen L, Shaw PW, Giedd JN. Neuron. 72:873–884 (2011) PMID: 22153381.

How does your cortex grow?. Raznahan A, Shaw P, Lalonde F, Stockman M, Wallace GL, Greenstein D, Clasen L, Gogtay N, Giedd JN. J Neurosci. 31:7174–7177 (2011) PMID: 21562281.

Sex-chromosome dosage effects on gene expression in humans. Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH. Proc Natl Acad Sci U S A. 115(28):7398-7403 PMID: 29946024.

Normative brain size variation and brain shape diversity in humans. Reardon PK, Seidlitz J, Vandekar S, Liu S, Patel R, Park MTM, Alexander-Bloch A, Clasen LS, Blumenthal JD, Lalonde FM, Giedd JN, Gur RC, Gur RE, Lerch JP, Chakravarty MM, Satterthwaite TD, Shinohara RT, Raznahan A. Science. 360(6394):1222-1227 PMID: 29853553.

Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive Variation. Seidlitz J, Váša F, Shinn M, Romero-Garcia R, Whitaker KJ, Vértes PE, Wagstyl K, Kirkpatrick Reardon P, Clasen L, Liu S, Messinger A, Leopold DA, Fonagy P, Dolan RJ, Jones PB, Goodyer IM; NSPN Consortium, Raznahan A, Bullmore ET. Neuron. 97(1):231-247.e7 PMID: 29276055.


Magnuson Clinical Center, Room 4D18, MSC 1367
BETHESDA, MD 20814

Phone: +1 301 435 7927
Fax: +1 301 402 0296

raznahana@mail.nih.gov