Ted Usdin, M.D., Ph.D.
Systems Neuroscience Imaging Resources
Dr. Usdin is the Director of the Systems Neuroscience Imaging Resource in the NIMH Intramural Research Program. He attended college at Johns Hopkins University. His graduate work in the Medical Scientist Training Program at Washington University in St. Louis with Gerald Fischbach focused on the identification of factors responsible for neuromuscular junction development. Dr. Usdin completed a residency in psychiatry at Stanford University and then in 1990 joined the NIMH Laboratory of Cell Biology. Before running the SNIR, he was Chief of the Section on Fundamental Neuroscience where he explored the biological role of tuberoinfundibular peptide, a neuropeptide that his group discovered.
The goal of the Systems Neuroscience Imaging Resource (SNIR) is to make tools for contemporary systems level molecular anatomy accessible to NIMH, and potentially other, investigators. Current approaches to investigation of brain circuits and systems require analyses of neuronal projections, gene expression, and protein distribution patterns at cellular or sub-cellular resolution across multiple brain regions. The SNIR is intended to provide access to appropriate hardware, software, wet lab procedures, training, support and expertise. The SNIR will facilitate access to technologies such as high-throughput wide-field microscopy, deep tissue imaging via laser scanning confocal microscopy, and light sheet microscopy. It will also facilitate the application of recently developed genetic, molecular, and imaging and image analysis techniques to the projects and problems of intramural investigators. A particular focus will be the facilitation of work incorporating advances in 3D reconstruction of specified circuits, cell types, and protein distributions, combining modern clearing, image acquisition, and volume reconstruction methods.
Regulation of hypothalamic signaling by tuberoinfundibular peptide of 39 residues is critical for the response to cold: a novel peptidergic mechanism of thermoregulation. Dimitrov EL, Kim YY, Usdin TB. J Neurosci. 2011 Dec 7;31(49):18166-79. doi: 10.1523/JNEUROSCI.2619-11.2011. PMID: 22159128.
Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues. Fegley DB, Holmes A, Riordan T, Faber CA, Weiss JR, Ma S, Batkai S, Pacher P, Dobolyi A, Murphy A, Sleeman MW, Usdin TB. Genes Brain Behav. 2008 Nov;7(8):933-42. doi: 10.1111/j.1601-183X.2008.00432.x. Epub 2008 Sep 17. PMID: 18700839.
Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain. Faber CA, Dobolyi A, Sleeman M, Usdin TB. J Comp Neurol. 2007 Jun 1;502(4):563-83. PMID: 17394159.
Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Dobolyi A, Ueda H, Uchida H, Palkovits M, Usdin TB. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1651-6. Epub 2002 Jan 29. PMID: 11818570.
TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Usdin TB, Hoare SR, Wang T, Mezey E, Kowalak JA. Nat Neurosci. 1999 Nov;2(11):941-3. PMID: 10526330.
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