Veronica Alvarez, Ph.D.
Section on Neurobiology of Compulsive Behaviors
Research Topics
Research in the Alvarez laboratory is focused on understanding the effects of drugs of abuse on synapses and neuronal connectivity with the purpose of revealing the cellular and circuit mechanisms that mediate reward-motivated behaviors and compulsive drug seeking. Given that only a portion of individuals who are exposed to substances of abuse develop substance use disorder, the team is particularly interested in understanding the mechanisms that create vulnerability to develop addictive behaviors. Their research applies multiple techniques ranging from approaches at the cellular and synaptic level to behavioral analysis and in vivo manipulations in wild-type and genetically-engineered mice.
Biography
Dr. Alvarez earned a Ph.D. in Neuroscience from the University of Buenos Aires, Argentina. She moved to the US and trained with Dr. John Williams at the Vollum Institute, OHSU, studying the firing properties of locus coeruleus neurons and its modulation by opioids. She later trained as a postdoctoral fellow with Dr. Bernardo Sabatini at Harvard Medical School, where she studied mechanisms of functional and morphological plasticity at glutamatergic synapses using electrophysiology and two-photon imaging. In 2008, she was recruited as an Investigator and Acting Chief of the Section on Neuronal Structure in the Intramural Research Program of NIAAA. In 2017, she co-founded the Center on Compulsive Behaviors, a collaborative initiative spanning multiple Institutes within the NIH and for which she serves as Director. As of 2023, she joined the NIMH Intramural Research Program as the chief of the Section on Neurobiology of Compulsive Behaviors.
Selected Publications
Shin JH, Goldbach HC, Burke DA, Authement ME, Swanson ES, Bocarsly ME, Hernandez S, Kwon HB, Cerveny SE, Mehr JB, Plotnikova AS, Mohanty A, Cummins AC, Pelkey KA, McBain CJ, Khaliq ZM, Eldridge MAG, Averbeck BB, Alvarez VA (2025). Local Regulation of Striatal Dopamine Release Shifts from Predominantly Cholinergic in Mice to GABAergic in Macaques. J Neurosci 45. https://doi.org/10.1523/JNEUROSCI.1692-24.2025. [Pubmed Link ]
NIHBC 35 – PNRC 1/1C-913
Phone: +1 240 271 1791