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Principal Investigator

Photo of Dr. Yogita Chudasama

Yogita Chudasama, Ph.D.

Biography

Yogita Chudasama is Chief of the Section on Behavioral Neuroscience, and Director of the Rodent Behavioral Core. Dr. Chudasama received her B.Sc (Hons) in Applied Psychology in 1991 and her Ph.D in 1995, both from Cardiff University, Wales, UK. Her Ph.D. was under the mentorship of Dr. Janice Muir where she studied prefrontal and thalamic contributions to learning, memory and attention. Her first postdoctoral fellowship (1998-2002) was in the Department of Experimental Psychology, University of Cambridge UK, with Prof. Trevor Robbins investigating psychopharmacological mechanisms of prefrontal cognitive function. Her second postdoctoral fellowship (2003-2006) was in the Laboratory of Neuropsychology at NIMH with Dr. Elisabeth Murray examining the emotional and cognitive contributions of the prefrontal cortex and temporal lobe. She was then recruited by McGill University in Montreal, Canada, and joined the faculty in the Psychology Department (2007-2015) where she established the Laboratory of Brain and Behavior. In Nov 2015, Dr. Chudasama joined the faculty in the Intramural Research Program (IRP) at the National Institute of Mental Health.

Research Interests

Dr. Chudasama has had a long standing interest in functional neuroanatomy, and specifically elucidating the brain mechanisms underlying the control of executive function, which are both central to human cognitive behavior and adversely affected in psychiatric disorders. Her laboratory focuses on the cognitive effects of manipulating particular brain circuits, and is at the forefront in state-of-the-art behavioral testing. While her laboratory pursues basic science questions, Dr. Chudasama’s work places a strong emphasis on translation to understanding human brain circuits, cognition, and dysfunction observed in mental disorders. Recently, work in her work has extended towards understanding the relationship between executive dysfunction and socioemotional dysregulation. Currently, her lab is actively investigating the network of forebrain and midbrain structures that not only steer complex executive behavior, but also regulates normal social development. To this end, Dr. Chudasama’s laboratory implements a range of methodologies including behavior, neuroanatomy and psychopharmacology, as well as viral and molecular genetics to provide us with a unique perspective on the detailed circuits that support executive behaviors that often go awry in human patients suffering from poor control over their decisions, memories, and actions.

Selected Publications

Abela AR, Duan Y, Chudasama Y (2015) Hippocampal interplay with the nucleus accumbens is critical for decisions about time. Eur J Neurosci 42:2224-33. [Pubmed Link]

Prasad JA, Abela AR, Chudasama Y (2017) Midline thalamic reuniens lesions improve executive behaviors. Neuroscience 345:77-88. [Pubmed Link]

Wilson EN, Abela AR, Do Carmo S, Allard S, Marks AR, Welikovitch LA, Ducatenzeiler A, Chudasama Y, Cuello AC (2017) Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease. Cereb Cortex 27:1501-1511. [Pubmed Link]

Jang AI, Costa VD, Rudebeck PH, Chudasama Y, Murray EA, Averbeck BB (2015) The Role of Frontal Cortical and Medial-Temporal Lobe Brain Areas in Learning a Bayesian Prior Belief on Reversals. J Neurosci 35:11751-60. [Pubmed Link]


Building 35A, Room 2D820, MSC 3749
BETHESDA, MD 20892

Phone: +1 301 594 4186

yogita.chudasama@nih.gov