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Negative Valence Systems: Potential Threat (Anxiety) - NIMH Research Domain Criteria (RDoC)

Domain: Negative Valence Systems
Construct: Potential Threat ("Anxiety")
————— Units of Analysis —————


CRF family, cortisol

Pituitary cells

Bed nucleus of stria terminalis

Average cortisol levels, ACTH, potentiated startle



Contextual threat, darkness (in humans), light (in rodents)