Negative Valence Systems: Potential Threat (Anxiety) - NIMH Research Domain Criteria (RDoC)
| Domain: Negative Valence Systems Construct: Potential Threat ("Anxiety") | |||||||
|---|---|---|---|---|---|---|---|
| ————— Units of Analysis ————— | |||||||
| Genes | Molecules | Cells | Circuits | Physiology | Behavior | Self-Reports | Paradigms |
|
CRF |
CRF family, cortisol |
Pituitary cells |
Bed nucleus of stria terminalis |
Average cortisol levels, ACTH, potentiated startle |
|
|
Contextual threat, darkness (in humans), light (in rodents) |